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Molecules 2011, 16(9), 7736-7745;

Synthesis and in Vitro Antimicrobial Activity of Some Pyrazolyl-1-carboxamide Derivatives

Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 426, Egypt
Department of Chemistry, Faculty of Education, Alexandria University, Alexandria 21526, Egypt
Author to whom correspondence should be addressed.
Received: 13 August 2011 / Revised: 25 August 2011 / Accepted: 31 August 2011 / Published: 9 September 2011
(This article belongs to the Special Issue Heterocycles)
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A series of 3,5-disubstituted pyrazole-1-carboxamides were obtained by treatment of chalcones with semicarbazide hydrochloride in dioxane containing sodium acetate/acetic acid as a buffer solution. N-acetyl derivatives of pyrazole-1-carboxamides were isolated in good yields either by treatment of the carboxamide derivatives with acetic anhydride or refluxing chalcones with semicarbazide in ethanol containing few drops of acetic acid to give the corresponding hydrazones. Subsequent treatment of hydrazones with acetic anhydride gave the desired N-acetyl pyrazole-1-carboxamides derivatives. When chalcones were refluxed with dioxane containing few drops of acetic acid, 4,5-dihydropyrazole-1-carboxamides were isolated, which were subsequently oxidized using 5% sodium hypochlorite in dioxane to afford pyrazole-1-carboxamides. The structures of isolated compounds were confirmed by elemental analyses and spectral methods. The isolated compounds were tested for their antimicrobial activities. View Full-Text
Keywords: chalcones; hydrazones; pyrazoles; pyrazolines chalcones; hydrazones; pyrazoles; pyrazolines

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Sharshira, E.M.; Hamada, N.M.M. Synthesis and in Vitro Antimicrobial Activity of Some Pyrazolyl-1-carboxamide Derivatives. Molecules 2011, 16, 7736-7745.

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