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Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation

1
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China
2
Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2011, 16(8), 6339-6348; https://doi.org/10.3390/molecules16086339
Received: 12 May 2011 / Revised: 5 July 2011 / Accepted: 14 July 2011 / Published: 26 July 2011
(This article belongs to the Section Natural Products Chemistry)
A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 79, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα. View Full-Text
Keywords: Radix Angelicae Dahuricae; furocoumarins; nuclear receptor RXRα Radix Angelicae Dahuricae; furocoumarins; nuclear receptor RXRα
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Liu, D.-P.; Luo, Q.; Wang, G.-H.; Xu, Y.; Zhang, X.-K.; Chen, Q.-C.; Chen, H.-F. Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation. Molecules 2011, 16, 6339-6348.

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