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A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

Green Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Taejon 305-600, Korea
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Molecules 2011, 16(8), 6313-6321; https://doi.org/10.3390/molecules16086313
Received: 1 July 2011 / Revised: 19 July 2011 / Accepted: 22 July 2011 / Published: 26 July 2011
An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity. View Full-Text
Keywords: 4-arylcoumarins; Kostanecki reaction; DBU; 3,4-disubstituted coumarins; one-pot reaction 4-arylcoumarins; Kostanecki reaction; DBU; 3,4-disubstituted coumarins; one-pot reaction
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Hwang, I.-T.; Lee, S.-A.; Hwang, J.-S.; Lee, K.-I. A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU. Molecules 2011, 16, 6313-6321.

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