Next Article in Journal
Neuroprotective Effects of Vanillyl Alcohol in Gastrodia elata Blume Through Suppression of Oxidative Stress and Anti-Apoptotic Activity in Toxin-Induced Dopaminergic MN9D Cells
Previous Article in Journal
Study of the Extraction Process and In Vivo Inhibitory Effect of Ganoderma Triterpenes in Oral Mucosa Cancer
Article Menu

Export Article

Open AccessReview
Molecules 2011, 16(7), 5333-5348;

Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo

Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Office of the Texas State Chemist, Texas A&M University, College Station, TX 77845, USA
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Author to whom correspondence should be addressed.
Received: 31 May 2011 / Revised: 21 June 2011 / Accepted: 21 June 2011 / Published: 24 June 2011
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [189 KB, uploaded 18 June 2014]   |  


Levuglandins (LGs) and isolevuglandins (isoLGs), formed by rearrangement of endoperoxide intermediates generated through the cyclooxygenase and free radical induced oxidation of polyunsaturated fatty acids (PUFAs), are extraordinarily reactive, forming covalent adducts incorporating protein lysyl e-amino groups. Because they accumulate, these adducts provide a dosimeter of oxidative injury. This review provides an updated and comprehensive overview of the generation of LG/isoLG in vitro and in vivo and the detection methods for the adducts of LG/isoLG and biological molecules in vivo. View Full-Text
Keywords: levuglandin; polyunsaturated fatty acids; oxidative injury levuglandin; polyunsaturated fatty acids; oxidative injury

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Zhang, M.; Li, W.; Li, T. Generation and Detection of Levuglandins and Isolevuglandins In Vitro and In Vivo. Molecules 2011, 16, 5333-5348.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top