Molecules 2011, 16(4), 3420-3432; https://doi.org/10.3390/molecules16043420
Proline-Catalysed Amination Reactions in Cyclic Carbonate Solvents
School of Chemistry, Research Centre in Catalysis and Intensified Processing, Bedson Building, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
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Received: 6 April 2011 / Revised: 19 April 2011 / Accepted: 20 April 2011 / Published: 21 April 2011
(This article belongs to the Special Issue Catalytic Asymmetric Synthesis)
Abstract
Propylene carbonate is shown to be an environmentally friendly and sustainable replacement for dichloromethane and acetonitrile in proline-catalysed a-hydrazinations of aldehydes and ketones. Enantioselectivities comparable to those obtained in conventional solvents or ionic liquids can be obtained, even when using a lower catalyst loading. View Full-TextKeywords:
proline; amination; cyclic-carbonate
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Beattie, C.; North, M.; Villuendas, P. Proline-Catalysed Amination Reactions in Cyclic Carbonate Solvents. Molecules 2011, 16, 3420-3432.
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