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Molecules 2010, 15(8), 5460-5472;

The Application of Ribozymes and DNAzymes in Muscle and Brain

Department of Molecular Genetics, Function & Therapy, The Cyprus Institute of Neurology & Genetics. PO Box 23462, Nicosia, Cyprus
Henry Welcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Whilston street, Bristol, BS13NY, UK
Author to whom correspondence should be addressed.
Received: 18 June 2010 / Revised: 3 August 2010 / Accepted: 5 August 2010 / Published: 9 August 2010
(This article belongs to the Special Issue Catalytic Nucleic Acids)
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The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of endogenous gene expression involved in these ailments. These CNAs aim either towards the elimination or repair of pathological gene expression. Ribozymes, a class of CNAs, can be mostly used to down-regulate (by RNA cleavage) or repair (by RNA trans-splicing) unwanted gene expression involved in disease. DNAzymes, derived by in vitro selection processes are also able to bind and cleave RNA targets and therefore down-regulate gene expression. The purpose of this review is to present and discuss several applications of ribozymes and DNAzymes in muscle and brain. There are several diseases which affect muscle and brain and catalytic nucleic acids have been used as tools to target specific cellular transcripts involved in these groups of diseases. View Full-Text
Keywords: catalytic nucleic acids; ribozyme; DNAzyme; brain; muscle catalytic nucleic acids; ribozyme; DNAzyme; brain; muscle

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Mastroyiannopoulos, N.P.; Uney, J.B.; Phylactou, L.A. The Application of Ribozymes and DNAzymes in Muscle and Brain. Molecules 2010, 15, 5460-5472.

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