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Open AccessArticle

Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase

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Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan
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Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
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Author to whom correspondence should be addressed.
Molecules 2010, 15(5), 3121-3134; https://doi.org/10.3390/molecules15053121
Received: 21 February 2010 / Revised: 22 April 2010 / Accepted: 26 April 2010 / Published: 28 April 2010
Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS). View Full-Text
Keywords: nitric oxide synthase; iNOS; stimulation; thienylmethylthioureas nitric oxide synthase; iNOS; stimulation; thienylmethylthioureas
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Suaifan, G.A.; Goodyer, C.L.; Threadgill, M.D. Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase. Molecules 2010, 15, 3121-3134.

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