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Molecules 2010, 15(4), 2246-2256; https://doi.org/10.3390/molecules15042246

Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms

1
Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia
2
Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
3
Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia
*
Author to whom correspondence should be addressed.
Received: 17 March 2010 / Revised: 26 March 2010 / Accepted: 29 March 2010 / Published: 30 March 2010
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Abstract

Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones.
Keywords: 4-heteroarylaminocoumarins; synthesis; 4-chloro-3-nitrocoumarin; spectral analysis; antimicrobial activity 4-heteroarylaminocoumarins; synthesis; 4-chloro-3-nitrocoumarin; spectral analysis; antimicrobial activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style

Dekić, B.R.; Radulović, N.S.; Dekić, V.S.; Vukićević, R.D.; Palić, R.M. Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms. Molecules 2010, 15, 2246-2256.

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