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Molecules 2010, 15(12), 9205-9213;

Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970, São Paulo, SP, Brazil
Institute of Chemistry, São Paulo State University, Box 355, 14801-970, Araraquara, SP, Brazil
Department of Chemistry and Physics, São Paulo University, 14040-903, Ribeirão Preto, SP, Brazil
Department of Botany, Biosciences Institute, São Paulo University, Box 11.461, 05422-970, São, Paulo, SP, Brazil
Author to whom correspondence should be addressed.
Received: 15 November 2010 / Revised: 2 December 2010 / Accepted: 6 December 2010 / Published: 13 December 2010
(This article belongs to the Section Natural Products Chemistry)
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Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
Keywords: Esenbeckia leiocarpa; Rutaceae; alkaloids; acetylcholinesterase inhibitors Esenbeckia leiocarpa; Rutaceae; alkaloids; acetylcholinesterase inhibitors

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Cardoso-Lopes, E.M.; Maier, J.A.; Silva, M.R.; Regasini, L.O.; Simote, S.Y.; Lopes, N.P.; Pirani, J.R.; Bolzani, V.S.; Young, M.C.M. Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease. Molecules 2010, 15, 9205-9213.

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