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Keywords = Esenbeckia leiocarpa

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Article
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
by Elaine Monteiro Cardoso-Lopes, James Andreas Maier, Marcelo Rogério da Silva, Luis Octávio Regasini, Simone Yasue Simote, Norberto Peporine Lopes, José Rubens Pirani, Vanderlan da Silva Bolzani and Maria Cláudia Marx Young
Molecules 2010, 15(12), 9205-9213; https://doi.org/10.3390/molecules15129205 - 13 Dec 2010
Cited by 80 | Viewed by 12437
Abstract
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for [...] Read more.
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity. Full article
(This article belongs to the Section Natural Products Chemistry)
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