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Article

New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity

1
Department of Medicinal Chemistry, Theodor Bilharz Research Institute, P.O.B. 12411, Giza, Egypt
2
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, P.O.B. 11795, Ain-Helwan, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(5), 1952-1965; https://doi.org/10.3390/molecules14051952
Received: 29 March 2009 / Revised: 8 May 2009 / Accepted: 13 May 2009 / Published: 25 May 2009
From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, 1H-, 13C-NMR, 1H-1H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line. View Full-Text
Keywords: Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2 Duranta repens; triterpene saponins; durantanin IV and V; brine shrimp; HepG2
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MDPI and ACS Style

Ahmed, W.S.; Mohamed, M.A.; El-Dib, R.A.; Hamed, M.M. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules 2009, 14, 1952-1965. https://doi.org/10.3390/molecules14051952

AMA Style

Ahmed WS, Mohamed MA, El-Dib RA, Hamed MM. New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity. Molecules. 2009; 14(5):1952-1965. https://doi.org/10.3390/molecules14051952

Chicago/Turabian Style

Ahmed, Wafaa S., Mona A. Mohamed, Rabab A. El-Dib, and Manal M. Hamed. 2009. "New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity" Molecules 14, no. 5: 1952-1965. https://doi.org/10.3390/molecules14051952

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