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Molecules 2009, 14(5), 1818-1824;

Phenoxypropylamines: Synthesis and Antiulcer Evaluation

College of Sciences, Northeastern University, Shenyang 110004, China
Department of Chemistry, Shenyang Medical College, Shenyang 110034, China
School of Public Health, China Medical University, Shenyang 110001, China
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
School of Medicinal Application & Technology, Shenyang Medical College, Shenyang 110034, China
Author to whom correspondence should be addressed.
Received: 9 April 2009 / Accepted: 8 May 2009 / Published: 13 May 2009
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We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity. View Full-Text
Keywords: roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity roxatidine; synthesis; antiulcer agents; phenoxypropylamine; biological activity

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Zhang, H.; Zhang, B.-Y.; Zhang, Q.-Y.; Zhao, D.-M.; Wang, J.-M. Phenoxypropylamines: Synthesis and Antiulcer Evaluation. Molecules 2009, 14, 1818-1824.

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