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Molecules 2009, 14(4), 1423-1428;

Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas

School of Chemistry and Chemical Engineering, Xinjiang University, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, 830046 Urumqi, P. R. China
Author to whom correspondence should be addressed.
Received: 28 February 2009 / Revised: 15 March 2009 / Accepted: 23 March 2009 / Published: 31 March 2009
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A series of novel bis(substituted pyrazol-4-ylcarbonyl)-substituted thioureas have been synthesized by the reactions of substituted pyrazol-4-ylcarbonyl isothiocyanates with different diamines under ultrasound irradiation and classical heating method at 20-25 °C. In general, substantial improvement in rates and modest yields increases were observed when reactions were carried out under sonication, compared with the classical heating method. The structures of these compounds have been elucidated by elemental and spectral (IR, 1H-NMR) analysis. View Full-Text
Keywords: Thiourea; Pyrazole; Diamine; Ultrasound; Synthesis Thiourea; Pyrazole; Diamine; Ultrasound; Synthesis

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Xiao, L.; Liu, C.-J.; Li, Y.-P. Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas. Molecules 2009, 14, 1423-1428.

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