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Open AccessArticle

Thermus thermophilus Strains Active in Purine Nucleoside Synthesis

Biotransformations Group. Servicio de Biotransformaciones Industriales. Parque Científico de Madrid. C/ Santiago Grisolia nº 2. 28760 Tres Cantos. Madrid, Spain
Centro de Biología Molecular Severo Ochoa, UAM 28049 Cantoblanco. Madrid. Spain
Department of Organic & Pharmaceutical Chemistry. Faculty of Pharmacy. Universidad Complutense, 28040 Madrid, Spain
Author to whom correspondence should be addressed.
Molecules 2009, 14(3), 1279-1287;
Received: 26 December 2008 / Revised: 25 February 2009 / Accepted: 11 March 2009 / Published: 24 March 2009
(This article belongs to the Special Issue Nucleic Acids)
Several strains of Thermus thermophilus were tested in order to detect purine nucleoside synthase activity using pyrimidine nucleosides as the sugar-donor and adenine or hypoxanthine as bases. High productivity values (t =1 hr) were obtained while completely avoiding adenosine-deaminase degradation of the products. N-2-deoxy-ribosyltransferase activity is described for the first time in hyperthermophilic bacteria. View Full-Text
Keywords: Biocatalysis; Nucleoside synthesis; Thermus thermophilus Biocatalysis; Nucleoside synthesis; Thermus thermophilus
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Almendros, M.; Gago, J.-V.; Carlos, J.B. Thermus thermophilus Strains Active in Purine Nucleoside Synthesis. Molecules 2009, 14, 1279-1287.

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