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Open AccessArticle

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

Department of Chemistry of Heterocyclic Compounds, SSI “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine
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Molecules 2009, 14(12), 5223-5234; https://doi.org/10.3390/molecules14125223
Received: 4 November 2009 / Revised: 3 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Molecular Diversity Feature Papers)
Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds. View Full-Text
Keywords: benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents
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Sirko, S.M.; Gorobets, N.Y.; Musatov, V.I.; Desenko, S.M. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules 2009, 14, 5223-5234.

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