Next Article in Journal
Chemical Constituents from Clematis delavayi var. spinescens
Previous Article in Journal
Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.
Article Menu

Export Article

Open AccessCommunication
Molecules 2009, 14(11), 4425-4432;

Depigmenting Effect of Catechins

Department of Life Science, College of Agriculture, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo, 194-8610, Japan
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
Author to whom correspondence should be addressed.
Received: 24 September 2009 / Revised: 29 October 2009 / Accepted: 2 November 2009 / Published: 4 November 2009
Full-Text   |   PDF [737 KB, uploaded 18 June 2014]   |  


The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA). The catechin group inhibited melanin synthesis in B16 melanoma cells. To elucidate the anti-melanogenic mechanism of the catechin group, we performed Western blotting analysis for crucial melanogenic protein, namely tyrosinase. The catechin group inhibited tyrosinase expression. These results indicate that the catechin group is a candidate anti-melanogenic agent and that it might be effective in hyperpigmentation disorders. View Full-Text
Keywords: catechin; gallic acid; melanogenesis; B16 melanoma; tyrosinase; α-MSH (α-melanocyte stimulating hormone) catechin; gallic acid; melanogenesis; B16 melanoma; tyrosinase; α-MSH (α-melanocyte stimulating hormone)

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Sato, K.; Toriyama, M. Depigmenting Effect of Catechins. Molecules 2009, 14, 4425-4432.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top