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Open AccessArticle

Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation

1
Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, Hradec Králové, 500 05, Czech Republic
2
Department of Microbiology, Regional Hospital, Kyjevská 44, Pardubice, 532 03, Czech Republic
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(10), 4180-4189; https://doi.org/10.3390/molecules14104180
Received: 8 September 2009 / Revised: 1 October 2009 / Accepted: 13 October 2009 / Published: 20 October 2009
The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides. The synthetic approach, analytical, and lipophilicity data of the newly synthesized compounds are presented. Two antituberculosis assays were used. Firstly, the antimycobacterial activity against four different Mycobacterium strains in a series of pyrazine derivatives was investigated. Secondly, the antimycobacterial evaluation was performed at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) program. Interesting in vitro antimycobacterial activity was found, N-(3-iodo-4-methylphenyl) pyrazine-2-carboxamide (9) was most active derivative compound against M. tuberculosis (MIC < 2.0 μmol/L), while another iodo derivative 5-tert-butyl-6-chloro-N-(3-iodo-4-methyl-phenyl)pyrazine-2-carboxamide (12) was the most active compound in the TAACF antituberculosis screening program (IC90 = 0.819 μg/mL). View Full-Text
Keywords: pyrazinecarboxamide synthesis; in vitro antimycobacterial screening; lipophilicity; SAR pyrazinecarboxamide synthesis; in vitro antimycobacterial screening; lipophilicity; SAR
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MDPI and ACS Style

Doležal, M.; Zitko, J.; Kešetovičová, D.; Kuneš, J.; Svobodová, M. Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation. Molecules 2009, 14, 4180-4189. https://doi.org/10.3390/molecules14104180

AMA Style

Doležal M, Zitko J, Kešetovičová D, Kuneš J, Svobodová M. Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation. Molecules. 2009; 14(10):4180-4189. https://doi.org/10.3390/molecules14104180

Chicago/Turabian Style

Doležal, Martin; Zitko, Jan; Kešetovičová, Diana; Kuneš, Jiří; Svobodová, Michaela. 2009. "Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation" Molecules 14, no. 10: 4180-4189. https://doi.org/10.3390/molecules14104180

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