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Molecules 2008, 13(6), 1372-1383;

Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, UT 84112, USA
Author to whom correspondence should be addressed.
Received: 3 June 2008 / Revised: 18 June 2008 / Accepted: 18 June 2008 / Published: 19 June 2008
(This article belongs to the Special Issue Natural Product Pre-fractionation)
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The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented. View Full-Text
Keywords: Sponge; Tunicate; Prefractionation; HP20SS; Marine Natural Products; LCMS. Sponge; Tunicate; Prefractionation; HP20SS; Marine Natural Products; LCMS.

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bugni, T.S.; Harper, M.K.; McCulloch, M.W.; Reppart, J.; Ireland, C.M. Fractionated Marine Invertebrate Extract Libraries for Drug Discovery. Molecules 2008, 13, 1372-1383.

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