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Facile Synthesis of Optically Active Imidazole Derivatives

Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, nam. Cs. legii 565, Pardubice, 53210, Czech Republic
Author to whom correspondence should be addressed.
Molecules 2007, 12(5), 1183-1190;
Received: 11 May 2007 / Revised: 22 May 2007 / Accepted: 23 May 2007 / Published: 30 May 2007
(This article belongs to the Special Issue Heterocycles)
Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding α-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine. View Full-Text
Keywords: Imidazole; condensation; optically active ligand Imidazole; condensation; optically active ligand
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MDPI and ACS Style

Marek, A.; Kulhanek, J.; Ludwig, M.; Bures, F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules 2007, 12, 1183-1190.

AMA Style

Marek A, Kulhanek J, Ludwig M, Bures F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules. 2007; 12(5):1183-1190.

Chicago/Turabian Style

Marek, Ales, Jiri Kulhanek, Miroslav Ludwig, and Filip Bures. 2007. "Facile Synthesis of Optically Active Imidazole Derivatives" Molecules 12, no. 5: 1183-1190.

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