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Correction published on 25 May 2009, see Molecules 2009, 14(5), 1950-1951.

Open AccessArticle
Molecules 2007, 12(5), 1125-1135;

Synthesis of Sulfonamides and Evaluation of Their Histone Deacetylase (HDAC) Activity

Department of Neuroscience and Medical Research Institute, College of Medicine, Ewha Womans University, Seoul 158–710, South Korea
Department of Neuroscience and Inam Neuro Science Research Center, Wonkwang University Sanbon Medical Center, Sanbondong, Gunpocity, Kyunggido, 435-040, South Korea
Author to whom correspondence should be addressed.
Received: 17 April 2007 / Revised: 18 May 2007 / Accepted: 18 May 2007 / Published: 24 May 2007
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A simple synthesis of sulfonamides 4–22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N–sulfonylation of L–proline benzyl ester hydrochloride (2) and coupling reaction of N–sulfonyl chloride 3 with amines in high yields. It was found that several compounds showed good cellular potency with the most potent compound 20 exhibiting an IC50 = 2.8 μM in vitro. View Full-Text
Keywords: HDAC; N–Sulfonylation; Coupling reaction; Anticancer HDAC; N–Sulfonylation; Coupling reaction; Anticancer

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Oh, S.; Moon, H.; Son, I.; Jung, J. Synthesis of Sulfonamides and Evaluation of Their Histone Deacetylase (HDAC) Activity. Molecules 2007, 12, 1125-1135.

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