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Molecules 2006, 11(7), 574-582;

Synthesis and Anticancer Activities of Novel 1,4-Disubstituted Phthalazines

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China
Author to whom correspondence should be addressed.
Received: 25 June 2006 / Revised: 12 July 2006 / Accepted: 13 July 2006 / Published: 27 July 2006
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A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method. View Full-Text
Keywords: Phthalazine derivatives; synthesis; anticancer activities. Phthalazine derivatives; synthesis; anticancer activities.

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Li, J.; Zhao, Y.-F.; Yuan, X.-Y.; Xu, J.-X.; Gong, P. Synthesis and Anticancer Activities of Novel 1,4-Disubstituted Phthalazines. Molecules 2006, 11, 574-582.

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