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Molecules 2006, 11(10), 758-767;

Synthesis and Natural Distribution of Anti-inflammatory Alkamides from Echinacea

Iowa State University Department of Chemistry, Ames, IA 50011, USA
Iowa State University Department of Genetics, Development and Cell Biology, Ames, IA 50011, USA
Author to whom correspondence should be addressed.
Received: 2 September 2006 / Revised: 10 October 2006 / Accepted: 16 October 2006 / Published: 18 October 2006
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The synthesis of the alkamides 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (1) and 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (5) was accomplished by organometallic coupling followed by introduction of the doubly unsaturated amide moiety. The distribution of these two amides in accessions of the nine species of Echinacea was determined. View Full-Text
Keywords: Echinacea; alkamides; synthesis. Echinacea; alkamides; synthesis.

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kraus, G.A.; Bae, J.; Wu, L.; Wurtele, E. Synthesis and Natural Distribution of Anti-inflammatory Alkamides from Echinacea. Molecules 2006, 11, 758-767.

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