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Open AccessArticle

Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity

1
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy Charles University, 500 05 Hradec Králové, The Czech Republic
2
Georgetown University, Washington DC 20057-1227, USA
3
Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Prague, Czech Republic
4
National Reference Laboratory for Mycobacterium Kansasii, Regional Institute of Hygiene, Ostrava, The Czech Republic
*
Author to whom correspondence should be addressed.
Molecules 2005, 10(7), 783-793; https://doi.org/10.3390/10070783
Received: 9 November 2004 / Revised: 4 March 2005 / Accepted: 10 March 2005 / Published: 31 August 2005
A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre. View Full-Text
Keywords: 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity
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MDPI and ACS Style

Vinsova, J.; Horak, V.; Buchta, V.; Kaustova, J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules 2005, 10, 783-793.

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