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Antioxidants
Volume 10
Issue 12
10.3390/antiox10121928
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Article

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

by
Erika Pambianchi
1,
Francesca Ferrara
2,
Alessandra Pecorelli
1,
Mascia Benedusi
2,
Hina Choudhary
3,
Jean-Philippe Therrien
4 and
Giuseppe Valacchi
1,2,5,*
1
Department of Animal Science, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC 28081, USA
2
Department of Environment and Prevention, University of Ferrara, 44121 Ferrara, Italy
3
SkinCeuticals, New York, NY 10001, USA
4
JP Therrien Consulting, LLC, 17107 Arkansas Ln, Davidson, NC 28036, USA
5
Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(12), 1928; https://doi.org/10.3390/antiox10121928
Submission received: 22 October 2021 / Revised: 25 November 2021 / Accepted: 26 November 2021 / Published: 30 November 2021
(This article belongs to the Special Issue Iron, Oxidative Stress, Skin Ageing and Disorders)
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Abstract

Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure. Among the pollutants, diesel engine exhaust (DEE) represents one of the most toxic, as it is composed of a mixture of many different noxious chemicals generated during the compression cycle, for ignition rather than an electrical spark as in gasoline engines. The toxic chemicals of most concern in DEE, besides the oxides of nitrogen, sulfur dioxide and various hydrocarbons, are metals that can induce oxidative stress and inflammation. The present study aimed to evaluate the effects of topical application, singularly or in combination, of the iron-chelator deferoxamine and a commercially available formulation, CE Ferulic, in up to 4-day DEE-exposed skin. DEE induced a significant increase in the oxidative marker 4-hydroxy-nonenal (4HNE) and matrix-metallopeptidase-9 (MMP-9), the loss of cutaneous-barrier-associated proteins (filaggrin and involucrin) and a decrease in collagen-1, while the formulations prevented the cutaneous damage in an additive manner. In conclusion, this study suggests that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations.
Keywords: cosmeceuticals; pollution; iron-chelator cosmeceuticals; pollution; iron-chelator

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MDPI and ACS Style

Pambianchi, E.; Ferrara, F.; Pecorelli, A.; Benedusi, M.; Choudhary, H.; Therrien, J.-P.; Valacchi, G. Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure. Antioxidants 2021, 10, 1928. https://doi.org/10.3390/antiox10121928

AMA Style

Pambianchi E, Ferrara F, Pecorelli A, Benedusi M, Choudhary H, Therrien J-P, Valacchi G. Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure. Antioxidants. 2021; 10(12):1928. https://doi.org/10.3390/antiox10121928

Chicago/Turabian Style

Pambianchi, Erika, Francesca Ferrara, Alessandra Pecorelli, Mascia Benedusi, Hina Choudhary, Jean-Philippe Therrien, and Giuseppe Valacchi. 2021. "Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure" Antioxidants 10, no. 12: 1928. https://doi.org/10.3390/antiox10121928

APA Style

Pambianchi, E., Ferrara, F., Pecorelli, A., Benedusi, M., Choudhary, H., Therrien, J.-P., & Valacchi, G. (2021). Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure. Antioxidants, 10(12), 1928. https://doi.org/10.3390/antiox10121928

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