1. Introduction
Dynamical systems often exhibit multiple local equilibrium configurations separated by potential barriers. The primary mechanism for the decay of these states is thermal activation over a potential barrier. This phenomenon has been widely investigated due to its significance in diverse fields such as chemistry, physics, and biology [
1].
A simple representation for thermal activation considers a classical particle in a bistable potential, , undergoing stochastic dynamics governed by a Langevin equation with additive white noise. A key quantity in this framework is the escape rate, which characterizes the particle’s transition from a local minimum of the potential.
Kramers’s pioneering work [
2] provides an elegant formula for the escape rate in symmetric potentials:
where
is the barrier height, with
and
denoting the positions of the maximum and the minimum of the potential, respectively. The noise intensity, represented as
, where
is the thermal energy, quantifies the strength of the stochastic fluctuations in the system, and
and
are frequencies associated with a parabolic approximation of the potential energy.
and
are the local curvatures of the potential at the minimum and the maximum and
m is the mass of the particle. This result holds in the weak noise regime (
).
Recently, we extended Kramers’s formula, given by Equation (
1), to systems with multiplicative noise [
3]. In such systems, the stochastic dynamics are driven by a state-dependent diffusion function,
. This state-dependent nature add further challenges and require a careful treatment using stochastic calculus, where the choice of interpretation, such as those by Itô, Stratonovich, or others, can influence the resulting dynamics [
4,
5,
6]. Understanding Kramers’s rate in the context of multiplicative noise is not merely of theoretical interest but has practical implications. A significant application is stochastic resonance, a phenomenon in which noise amplifies the response of a nonlinear system to weak periodic signals [
7].
In addition, evidence of heterogeneous diffusion has been observed in very different systems such as gene expression processes [
8], microparticles in confined geometries [
9,
10], and colloids [
11,
12]. From a theoretical perspective, stochastic systems with multiplicative noise, i.e., with heterogeneous diffusion, have been investigated using a variety of approaches. These range from numerical simulations of Langevin equations [
13,
14,
15,
16] to mean-field approximations of Fokker–Planck equations [
17] and further to path integral techniques [
18,
19,
20,
21], which are particularly well suited for exploring symmetries, conserved quantities, and fluctuation theorems [
22].
While prior studies of Kramers’s escape rate and its generalizations have primarily addressed symmetric potentials, real-world systems often exhibit asymmetric potential landscapes. Asymmetries introduce new complexities, such as unequal barrier heights and different curvatures at the minima, which significantly impact escape dynamics. This requires further generalization of classic escape rate formulas.
In this work, we derive an explicit analytic formula for the escape rate in stochastic systems with multiplicative noise under asymmetric potentials. We use a broad stochastic framework to define the Langevin equation, which includes the most common interpretations of stochastic integration. Our analysis highlights how asymmetry modifies the escape rate and its dependence on the stochastic prescription. The main result of this paper is the explicit analytic expression for the decay rate
where
is the height of the equilibrium potential barrier related to each of the minima
or
,
s are the local curvatures of the equilibrium potential at the minima or the maximum of the potential, and
is the diffusion function evaluated at the local maximum of
. In this case, the square of the diffusion function is playing the role of the inverse of the mass, since the actual frequency is proportional to
. The main feature of this expression is that it depends neither on the details of the equilibrium potential nor on those of the diffusion function. Instead, it relies solely on the local properties of these quantities, such as the height of the barrier and the local curvatures at the minima and maximum. On the other hand, all the information about the specific stochastic prescription defining the multiplicative noise process is encapsulated in the equilibrium potential. This potential incorporates not only the original bare potential but also information on the multiplicative noise fluctuations. Moreover, we observe that both minima, the global and the metastable one, contribute to the decay rate, independently of the initial conditions of the process.
We calculate the escape rate using the conditional probabilities of state transitions over time. The computation employs path integral techniques, utilizing an instanton–anti-instanton expansion valid in the weak noise limit and long times. Our approach closely follows the methods in [
3,
23]. Additionally, we perform extensive numerical simulations of the Langevin equation for specific potential and diffusion functions. These results enable us to evaluate the validity and limitations of our approximations.
The structure of this paper is as follows.
Section 2 present the theoretical framework for analyzing asymmetric potentials in the presence of additive and multiplicative noise.
Section 3 reviews the path integral approach to stochastic processes, emphasizing its application to escape rate calculations. In
Section 4, we derive the weak noise approximations for escape rates in asymmetric potentials, presenting the main result of this paper given by Equation (
2). Numerical simulations and comparisons with analytic results are presented in
Section 5. Finally, we provide a summary of our findings and discuss potential applications in
Section 6.
2. A Simple Representation of State-Dependent Diffusion
Consider a one-dimensional conservative system characterized by a potential energy function,
, that has a double-well structure. The system interacts with a thermal bath described by a state-dependent diffusion function,
. The overdamped Langevin equation is given by
where
is a Gaussian white noise, thus satisfying
The drift force and the diffusion function are represented by
and
, respectively, which are arbitrary smooth functions of
x, and
measures the noise intensity. The symbol
over the equal sign indicates that the Langevin equation is interpreted in the generalized Stratonovich [
24] convention or
-prescription [
25]. In this prescription,
is defined as a continuous parameter,
, and each of its values corresponds with a different discretization rule for the stochastic differential equation.
corresponds to the Itô interpretation, while
corresponds to the Stratonovich one. Additionally,
is known as the Hänggi–Klimontovich (or kinetic) interpretation [
6,
26]. It is always good to emphasize that each stochastic prescription leads to a different stochastic evolution of Equation (
3) and determines specific rules of differential calculus. Thus, the discretization prescription is an inherent component of the model.
To achieve thermodynamic equilibrium, the drift force
must be connected to the potential
and the dissipation function
via a generalized Einstein relation [
19], in such a way that
Under this condition, the Langevin Equation (
3) can be rewritten as
The equilibrium probability distribution over long times takes the form
where
is a normalization constant, and the equilibrium potential
, obtained by solving the related stationary Fokker–Planck equation [
19], is represented by
where
is an arbitrary scale parameter. Naturally, no physical observable can depend on this parameter, as it merely represents a constant shift in the potential energy reference. Notice that the equilibrium distribution depends on the original potential as well as on the diffusion function
and the stochastic prescription
. Notably,
(the kinetic interpretation) is the unique stochastic prescription which results in the Boltzmann distribution,
.
There is a relation between stochastic differential equations defined in different prescriptions. Sometimes, it could be useful to represent the same stochastic process in a different prescription. In this context, the process given by Equation (
3) in the
prescription can be formulated by using an alternative differential equation defined in another discretization (say, in the stochastic prescription
) through the following equation:
with
where primes,
, means derivative with respect to
x. A thorough proof is provided in the appendix of ref. [
3]. This property is very useful because, depending on the calculation techniques, some prescriptions are more convenient or easier to be implemented. For instance, for analytic calculations, the Stratonovich prescription
is simpler because the calculus rules, such as the chain rule or integration by parts, turn out to be the usual ones. Alternatively, the Itô interpretation (
) is the unique prescription which guarantees the non-anticipating property for stochastic calculus [
4] and makes easier to perform numerical simulations.
Although the techniques and results presented here are general, we illustrate the equilibrium potential
using a simple bistable model,
in which the term
breaks the parity symmetry. For the diffusion function, we choose
where
quantifies the multiplicative nature of the noise. For
, the noise is additive. To outline the general characteristics of the equilibrium potential, we express Equations (
11) and (
12) in arbitrary units. A discussion about dimensions will follow the presentation of our main result, Equation (
35).
The potential
exhibits two minima (degenerated for
) and a local maximum. The multiplicative noise introduces significant effects in the equilibrium potential. In
Figure 1, the equilibrium potential
, defined by Equation (
8), is illustrated for the simplest symmetric model described by Equations (
11) and (
12) (with
), considering different values of the parameters
and
.
Figure 1a shows the equilibrium potential for
under various stochastic prescriptions,
. For
, we find
, with the minima fixed at
. In contrast, under the Stratonovich and Itô prescriptions, the minima shift toward the origin. In
Figure 1b, the curves are computed using the Itô prescription for different noise intensities,
. In this case, as the noise increases, the minima move closer to zero; for the largest value
, the equilibrium potential exhibits a single global minimum at
. As noted in ref. [
3], this behavior resembles a second-order phase transition induced by spontaneous symmetry breaking. This is in contrast to the asymmetric case shown in
Figure 2, where we fix
. In this case, there is a metastable local minimum and a global minimum separated by a barrier. Similarly to the symmetric case, in
Figure 2a, we show how the minima approach as the prescription goes from
to
, as well as the differences in the height of the barrier for the stochastic prescriptions. This aspect clearly impacts the validity range of the Kramers rate. In
Figure 2b, we show the equilibrium potential in the Itô prescription for different values of noise. It is possible to see that with increasing noise, the barrier height decreases and the metastable state disappears, in a similar way to a spinodal decomposition mechanism. Therefore, the effects of multiplicative noise on the equilibrium properties of the systems are nontrivial, in the symmetric as well as in the asymmetric case.
3. Path Integral Representation of Langevin Dynamics with Multiplicative White Noise
We present here the formalism used to compute conditional probabilities. This section is not entirely novel; however, it is necessary to introduce the notation and to make a self-contained presentation. We briefly outline the method and refer the interested reader to the cited references for technical details.
Conditional probabilities are expressed by the means of the path integral representation of the generating functional of stochastic correlations. In order to build the path integral, it is convenient to work in the Stratonovich prescription. Thus, using Equation (
9), with
, the stochastic process given by Equation (
6), defined in the
-prescription sense, is described by the Langevin equation
with
where, now, the stochastic differential equation is integrated in the Stratonovich sense. In this equation,
is just a parameter contained in the definition of the drift force
.
The transition probability
plays a fundamental role in studying any dynamical property of a stochastic process. It represents the conditional probability of the system being in the state
at the time
, given that it was in the state
at the time
. Within the path integral formalism, this probability can be expressed as [
21,
23,
27]
where the “action”
is given by
with the boundary conditions
and
. Equations (
15) and (
16) coincide with the Onsager–Mashlup representation [
28] of the conditional probability for the stochastic process governed by Equation (
13). Although slightly different versions of Equation (
16) have been reported [
21,
23,
27], essentially due to the covariant properties of the formalism, the differences are of the order
[
29] and do not affect the present computation of the transition probability, as we explain below.
Rewriting the action in an alternative form is very insightful. By expanding the squared bracket in Equation (
16) and applying Equations (
14), (
5), and (
8), followed by integration by parts, we obtain
where
denotes the time derivative. The first term is a state function defined by the equilibrium potential
, evaluated in the system’s initial and final states, such that
, where
is determined by Equation (
8). The Lagrangian can be expressed in the following suggestive form:
where
The first interesting result is that, for the order
, all the dependence on the parameter
is encoded in the equilibrium potential
(Equation (
8)), strengthening the role of this quantity not only for equilibrium properties but also for dynamic evolution.
Replacing Equation (
17) in Equation (
15), the conditional probability takes the form
with
represented by
which is commonly known as a
propagator in the quantum mechanics literature. Here, the initial and final conditions are considered
and
The functional integration measure takes the form
with
.
Notably, the Equation (
21) is the exact propagator for a quantum particle with a position-dependent mass,
, moving in a potential,
, written within the imaginary time path integral formalism
[
23]. In this context, the noise intensity
serves as the counterpart of
ℏ in the quantum theory.
4. Weak Noise Expansion and the Kramers Escape Rate
We analytically compute
in Equation (
21) in a weak noise approximation. The propagator can be written in the saddle-point expansion with Gaussian fluctuations as
The functions
, with
, denote the solutions (or approximate solutions) of the equation of motion
with
and
as initial and final conditions.
The classical action in Equation (
23) is
while the fluctuation kernel is given by
In Equation (
23), the functional integration measure is represented as
and fluctuations satisfy the boundary conditions
.
The main task is to compute all solutions of Equation (
24) and the corresponding fluctuation integral around each one. In
Figure 3, the opposite of the potential
is displayed, considering its general form given by Equation (
19). The first observation is that
has three maxima and two minima. The positions of the lateral maxima roughly align with the minima of the potential
, with a difference of the order
. The primary effect of the diffusion function is an increase in the curvature at each maximum by a factor proportional to
. A key feature, important for computing conditional probabilities, is that the height differences between the peaks are of the order
. Therefore, in a weak noise regime, the three maxima are quasi-degenerated.
For simplicity, let us generically call
the position of one of the lateral maxima, say,
in
Figure 3, and
the position of the other maximum
in the same figure. Moreover, we call
the position of the central maximum (
in the figure).
We are interested in computing, for example, the probability that the system remains within one of the wells of
, specifically around
. In this case, given that
,
in Equation (
20), and the propagator corresponds to the probability of the system staying in the same state. Thus, we want to compute
The first task is to compute solutions of the equation of motion, Equation (
24), with the conditions
. A trivial solution is simply
, and it is possible to compute its contribution to the propagator. Details of the calculation can be found in ref. [
3]. So, we obtain
denoting
by
and where the superscript
is used to highlight the contribution of the constant solution to the propagator.
Moreover, for very long times, the dynamics of the system exhibit topological time-dependent solutions with finite action that connect the maxima of the potential. These solutions, commonly referred to as instantons and anti-instantons, play a critical role in calculating the propagator. Over extended time intervals, nontrivial contributions to the path integral arise from the well-separated superposition of instantons and anti-instantons. The methodology for summing over these configurations, known as the dilute instanton/anti-instanton gas approximation, has been extensively developed to compute tunneling amplitudes in quantum mechanics [
30,
31,
32]. In the context of stochastic processes, this approach has been applied to systems driven by additive white noise [
33], as well as to scenarios involving colored noise [
34,
35,
36,
37]. Stochastic systems with multiplicative noise and symmetric potentials were recently treated in ref. [
3]. In this paper, we generalize the results presented in the last reference to asymmetric potentials.
In our case, the simplest instanton/anti-instanton solution that satisfies the boundary conditions is a trajectory that begins at
at the time
, goes to
at some intermediate time,
, and goes back to
at the time
. We use the schematic notation
to indicate this trajectory. By following standard, albeit laborious, procedures, we obtain [
3]
where
represents the contribution from the constant solution, as expressed in Equation (
29), and
As can be observed in Equation (
30), at long times, the contribution to the propagator of a simple instanton/anti-instanton configuration is a linear function of time. Furthermore, the structure of the coefficient
is revealing. This is the unique term in the theory containing the equilibrium potential,
, which, at the same time, completely encloses the information relative to the stochastic calculus. Additionally,
depends on the curvature at the maximum and the minimum of the equilibrium potential,
and
, respectively, and on the barrier height,
, without any dependence on the explicit details of
.
The propagator also receives important contributions from other solutions of Equation (
24). There are trajectories that contain two instantons and two anti-instantons, which we schematically depict as
. This is the case, for example, of trajectories beginning in
that go to
, passing through
, and then return to
. The contribution of these trajectories to the propagator can be computed by following the same technique as for the previous calculation of
trajectories [
3]. Performing so, in this case, we find
where
has the same structure of
given by Equation (
31), just by changing
in all places. As can be seen, trajectories of this kind (
) produce a quadratic time contribution to the propagator, with a coefficient proportional to
.
Combinations of these types of configurations are, in the long-time approximation, also quasi-solutions of Equation (
24) and should be considered in the summation of the propagator of Equation (
23). Typical trajectories would be
where
are integer numbers. The final infinite summation is a combinatory problem that can be exactly summed [
3,
33], obtaining
where the decay rate is given by
. Explicitly, we find, for the decay rate,
where
,
and
are the local curvatures at the minima and the maximum of the equilibrium potential. Moreover,
are the barrier height, measured from each of the asymmetric minima.
Equation (
35) is the main contribution of this paper. It presents an analytic expression for the Kramers decay rate in the case of state-dependent diffusion for asymmetric potentials. The main approximations involved in our calculation are the assumption of a weak noise,
, and the expansion for long times,
.
At this point, it is useful to verify the dimensional consistency of Equation (
35). Starting from the overdamped Langevin equation, Equation (
3), and using the Einstein relation, Equation (
5), we deduce that
and
, where
denotes the dimensional units of a quantity and
L represents a characteristic unit of length. From these considerations, it follows straightforwardly that
, as expected. Interestingly, given a characteristic length scale,
, and the energy scale
, the characteristic time scale is determined by the value of the diffusion function
. These are the only parameters that appear in the Langevin equation, Equation (
3).
Equation (
35) is a nontrivial generalization of previous results. For instance, for
in the original potential,
and, in this case,
. In these conditions, Equation (
35) reduces to the expression computed in ref. [
3]. On the other hand, for
or
, the stochastic dynamics are additive and our results converge to that of reference [
33].
5. Numerical Simulations
For the purpose of validating the expression for the Kramers escape rate given by Equation (
35), we performed extensive numerical simulations for the stochastic process governed by the Langevin Equation (
6) by using the Euler–Maruyama scheme. This algorithm was based on an Itô interpretation of the stochastic differential equation (SDE). Therefore, given that the Langevin equation was initially considered in the general
-prescription, it had to be transformed to an Itô-defined Langevin equation by the means of Equation (
10), taking
. Consequently, any
-defined SDE, for
, could be represented through the following Itô differential equation:
For the model described by Equations (
11) and (
12), the Itô stochastic differential equation can be explicitly written as
where
is a standard Wiener process with
and
. The white noise
is formally defined as the time derivative of the Wiener process. This relation is understood in the context of distributions, where
represents a generalized derivative [
4].
In
Figure 4, a typical path from Equation (
39) is depicted for a particular noise realization and by making
in the expression of the potential function
, Equation (
11). With the initial condition
fixed, the dynamics of the stochastic variable
become evident, as they fluctuate around the potential minima
, transitioning between them at seemingly irregular intervals. In this case, the global minimum of the potential is the negative one,
, and its barrier is higher, further increasing the likelihood that the system remains around this minimum for longer periods.
To ensure reliable statistical results, the mean value
was computed over a significant number of distinct noise realizations.
Figure 5 displays the results obtained by averaging over
noise configurations for various stochastic prescriptions. As expected,
converges exponentially toward the equilibrium value
with the equilibrium probability distribution
represented by Equation (
7).
Figure 5 also reveals that the typical decay rate varied across different stochastic prescriptions, with
, where
,
, and
represent the decay rates for the Itô, Stratonovich, and Kinetic prescriptions, respectively. This is aligned with the observation in
Figure 2a, which shows that the height of the equilibrium potential barrier increases as
grows. This behavior is independent of the initial condition used in the SDE integration. As shown in
Figure 6, simulations starting near both the metastable and global minima illustrate this point. It is possible to observe that the reached equilibrium state as well as the decay rates do not depend on initial conditions. It can also be distinguished that the equilibrium state for the Itô prescription has the smallest absolute value, while it is the largest for the anti-Itô convention. This is further represented in
Figure 1a and
Figure 2a; the Itô-defined SDE always exhibits the lowest potential barrier, facilitating transitions between minima in this prescription.
By means of the asymptotic conditional probability distribution derived in
Section 4, Equation (
34), it was possible to obtain an analytical expression for
in the long-time limit. It can be shown that, for
,
where
r is given by Equation (
35) and
A is a constant used as a fitting parameter. Equation (
41) was used to fit the numerical simulations curves and is graphically represented in
Figure 5, demonstrating excellent agreement between the theoretical result and simulations across all three stochastic prescriptions.
As an additional validation of the results, we plotted the logarithm of fluctuations around the equilibrium state,
where
, and a linear least-square fitting of
was made. We used an arbitrary scale to split up
, since it does not affect the value of
. Notice that the decay rate is given by the slope of the linear function and does not depend on any fitting parameter. This number, measured from the data, must be compared with the analytic expression of the decay rate given by Equation (
35). Using this approach, we explored a broad range of the parameter space
.
In
Figure 7, the decay rate
r, represented as a function of the noise intensity
, is displayed for the three stochastic prescriptions under consideration. The continuous, dashed, and dash–dotted curves were derived from Equation (
35), corresponding to the Itô, Stratonovich, and kinetic (or anti-Itô) interpretations, respectively. Numerical results, obtained via the least-squares fitting of
, are represented by diamond markers. Each diamond reflects computations based on at least
numerical simulations for each pair of values of
and
, with
and
. A remarkable agreement can be perceived across nearly the entire range of noise intensity. A slight deviation occurs for higher noise values, where
, as expected, since the Arrhenius approximation becomes less reliable in this regime. The first noticeable deviations in the results correspond to the Itô interpretation, as further highlighted in
Figure 8.
The decay rate
r as a function of the stochastic prescription
, with
, is shown in
Figure 9, for a noise range from
to
. Once again, an excellent agreement between the theoretical predictions derived from Equation (
35) and the results obtained through numerical simulations of the Langevin equation is observed. It is important to highlight that this analytic expression was obtained in the limit
. Therefore, the most precise and accurate values of
, given by Equation (
35) are expected for
.
For the sake of comparison between the different stochastic prescriptions, in
Figure 8,
is displayed as a function of the noise
for the Itô (dash–dotted line), Stratonovich (dotted line), and kinetic (dashed line) conventions. The figure shows that in the kinetic prescription, this quantity is always less than unity within the studied noise range. This indicates that the noise intensity is consistently much lower than the potential barrier, resulting in an excellent agreement, as observed in
Figure 7 and
Figure 9. On the other hand, for the Stratonovich and Itô prescriptions, we observe a critical value of
in which
. For noise intensity above this critical value, a good agreement between analytical and simulation results is no longer expected.
Most of the results exhibited in
Figure 7 and
Figure 9 correspond to values of
within the interval
. The results are highly accurate within this range; however, as pointed before, for the Itô prescription, the value of
r at
slightly deviates from the numerical data. At this noise intensity,
. The deviation becomes more pronounced in
Figure 7 for the Itô prescription at
, as confirmed by the corresponding curve in
Figure 8. This general behavior is expected because, as noted in
Section 2, the barrier height decreases as
and for increasing values of noise. Indeed, there is a critical noise level at which the barrier completely disappears and the system dramatically changes its dynamics.
6. Discussion and Conclusions
In this paper, we explored the dynamics of bistable systems influenced by multiplicative noise, presenting both analytical and numerical approaches to understand escape rates within asymmetric potentials. Our work generalized Kramers’s formula to systems with state-dependent diffusion, highlighting the impact of the stochastic prescription and asymmetry of the potential on equilibrium properties and transition rates. Among other applications, it serves as a starting point for studying stochastic resonance in systems governed by stochastic differential equations with multiplicative noise.
The main result of this paper is presented by Equation (
35). The derived analytic expression for decay rates, validated through extensive numerical simulations, provides a robust framework for analyzing stochastic systems with multiplicative noise. Interestingly, the weak noise approximation was demonstrated to be effective, as evidenced by the excellent agreement between theoretical predictions and simulation data across various noise intensities and stochastic prescriptions.
In
Figure 7, it can be clearly observed that the decay rate computed using the Itô prescription is greater than that computed with the Stratonovich interpretation, which in turn is greater than the rate computed with the Hänggi–Klimontovich prescription. Furthermore, in
Figure 9, we demonstrate that the decay rate as a function of the prescription,
, is a monotonically decreasing function. This behavior is due to two main reasons. First, the decay rate is primarily related to the first moment of the probability distribution, as
in the long-time limit where
. It has been analytically shown [
18,
19], at least for short times, that in systems with state-dependent diffusion the stochastic prescription significantly influences the mean value
while leaving the mean square displacement (MSD)
relatively unchanged. This agrees with numerical simulations, which show that the scaling properties of the MSD are independent of the stochastic prescription. Indeed, the prescription only affects the prefactor of the MSD, with a rather weak dependence [
15]. Second, the most significant effect of the prescription lies in its modification of the equilibrium potential
, as described by Equation (
8). In
Figure 1a and
Figure 2a, we illustrate how heterogeneous diffusion alters the potential. It is evident that for the same noise level, the parameter
changes the height of the potential barrier. Specifically, in the Hänggi–Klimontovich prescription (
), the barrier is the highest. Thus, the particle remains more time in the well, resulting in the smallest decay rate. Conversely, in the Itô prescription, the barrier is the lowest, leading to the greater decay rate since the particle can escape from the well more easily. This effect can be so pronounced that it modifies the entire structure of the potential for sufficiently large noise levels, as shown in
Figure 1b and
Figure 2b.
Equation (
35) for the decay rate underscores the critical role of the equilibrium potential
, which completely codifies the dependence of the dynamics on the stochastic discretization prescriptions. Our findings reveal that the choice of stochastic prescriptions directly influences decay rates, reflecting the underlying physics encoded in the critical points of the equilibrium potential and its local curvatures. Furthermore, the generalization to asymmetric potentials enriches the applicability of Kramers’s framework, accommodating a broader class of real-world systems.
Future investigations could extend this work by exploring higher-order corrections to the weak noise approximation and considering multidimensional landscapes. Such endeavors would further deepen our understanding of noise-induced transitions in complex systems.