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Article

Dynamic Effects in Nucleation of Receptor Clusters

1
National Research Center for Hematology, 125167 Moscow, Russia
2
Moscow Institute of Physics and Technology, 141701 Dolgoprudny, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Jürn W. P. Schmelzer
Entropy 2021, 23(10), 1245; https://doi.org/10.3390/e23101245
Received: 14 September 2021 / Revised: 21 September 2021 / Accepted: 22 September 2021 / Published: 24 September 2021
(This article belongs to the Special Issue Crystallization Thermodynamics)
Nucleation theory has been widely applied for the interpretation of critical phenomena in nonequilibrium systems. Ligand-induced receptor clustering is a critical step of cellular activation. Receptor clusters on the cell surface are treated from the nucleation theory point of view. The authors propose that the redistribution of energy over the degrees of freedom is crucial for forming each new bond in the growing cluster. The expression for a kinetic barrier for new bond formation in a cluster was obtained. The shape of critical receptor clusters seems to be very important for the clustering on the cell surface. The von Neumann entropy of the graph of bonds is used to determine the influence of the cluster shape on the kinetic barrier. Numerical studies were carried out to assess the dependence of the barrier on the size of the cluster. The asymptotic expression, reflecting the conditions necessary for the formation of receptor clusters, was obtained. Several dynamic effects were found. A slight increase of the ligand mass has been shown to significantly accelerate the nucleation of receptor clusters. The possible meaning of the obtained results for medical applications is discussed. View Full-Text
Keywords: nucleation theory; receptor clusterization; von Neumann entropy; kinetic barrier; cell signaling nucleation theory; receptor clusterization; von Neumann entropy; kinetic barrier; cell signaling
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MDPI and ACS Style

Prikhodko, I.V.; Guria, G.T. Dynamic Effects in Nucleation of Receptor Clusters. Entropy 2021, 23, 1245. https://doi.org/10.3390/e23101245

AMA Style

Prikhodko IV, Guria GT. Dynamic Effects in Nucleation of Receptor Clusters. Entropy. 2021; 23(10):1245. https://doi.org/10.3390/e23101245

Chicago/Turabian Style

Prikhodko, Ivan V., and Georgy Th. Guria. 2021. "Dynamic Effects in Nucleation of Receptor Clusters" Entropy 23, no. 10: 1245. https://doi.org/10.3390/e23101245

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