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Open AccessArticle

Groupwise Non-Rigid Registration with Deep Learning: An Affordable Solution Applied to 2D Cardiac Cine MRI Reconstruction

Laboratorio de Procesado de Imagen, E.T.S.I. Telecomunicación, Universidad de Valladolid, Paseo Belén 15, 47011 Valladolid, Spain
Unidad de Imagen Cardiaca, Hospital Clínico Universitario de Valladolid, CIBER de Enfermedades Cardiovasculares (CIBERCV), 47005 Valladolid, Spain
Author to whom correspondence should be addressed.
Entropy 2020, 22(6), 687;
Received: 15 May 2020 / Revised: 15 June 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
Groupwise image (GW) registration is customarily used for subsequent processing in medical imaging. However, it is computationally expensive due to repeated calculation of transformations and gradients. In this paper, we propose a deep learning (DL) architecture that achieves GW elastic registration of a 2D dynamic sequence on an affordable average GPU. Our solution, referred to as dGW, is a simplified version of the well-known U-net. In our GW solution, the image that the other images are registered to, referred to in the paper as template image, is iteratively obtained together with the registered images. Design and evaluation have been carried out using 2D cine cardiac MR slices from 2 databases respectively consisting of 89 and 41 subjects. The first database was used for training and validation with 66.6–33.3% split. The second one was used for validation (50%) and testing (50%). Additional network hyperparameters, which are—in essence—those that control the transformation smoothness degree, are obtained by means of a forward selection procedure. Our results show a 9-fold runtime reduction with respect to an optimization-based implementation; in addition, making use of the well-known structural similarity (SSIM) index we have obtained significative differences with dGW with respect to an alternative DL solution based on Voxelmorph. View Full-Text
Keywords: non-rigid registration; elastic motion; CNN; deep learning non-rigid registration; elastic motion; CNN; deep learning
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Martín-González, E.; Sevilla, T.; Revilla-Orodea, A.; Casaseca-de-la-Higuera, P.; Alberola-López, C. Groupwise Non-Rigid Registration with Deep Learning: An Affordable Solution Applied to 2D Cardiac Cine MRI Reconstruction. Entropy 2020, 22, 687.

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