First-Stage Prostate Cancer Identification on Histopathological Images: Hand-Driven versus Automatic Learning
AbstractAnalysis of histopathological image supposes the most reliable procedure to identify prostate cancer. Most studies try to develop computer aid-systems to face the Gleason grading problem. On the contrary, we delve into the discrimination between healthy and cancerous tissues in its earliest stage, only focusing on the information contained in the automatically segmented gland candidates. We propose a hand-driven learning approach, in which we perform an exhaustive hand-crafted feature extraction stage combining in a novel way descriptors of morphology, texture, fractals and contextual information of the candidates under study. Then, we carry out an in-depth statistical analysis to select the most relevant features that constitute the inputs to the optimised machine-learning classifiers. Additionally, we apply for the first time on prostate segmented glands, deep-learning algorithms modifying the popular VGG19 neural network. We fine-tuned the last convolutional block of the architecture to provide the model specific knowledge about the gland images. The hand-driven learning approach, using a nonlinear Support Vector Machine, reports a slight outperforming over the rest of experiments with a final multi-class accuracy of
Externally hosted supplementary file 1
Description: Database composed of three types of gland candidates: false glands, benign glands and pathological glands.
Externally hosted supplementary file 2
Description: The resulting code of this work is also publicly available here.
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García, G.; Colomer, A.; Naranjo, V. First-Stage Prostate Cancer Identification on Histopathological Images: Hand-Driven versus Automatic Learning. Entropy 2019, 21, 356.
García G, Colomer A, Naranjo V. First-Stage Prostate Cancer Identification on Histopathological Images: Hand-Driven versus Automatic Learning. Entropy. 2019; 21(4):356.Chicago/Turabian Style
García, Gabriel; Colomer, Adrián; Naranjo, Valery. 2019. "First-Stage Prostate Cancer Identification on Histopathological Images: Hand-Driven versus Automatic Learning." Entropy 21, no. 4: 356.
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