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Information Thermodynamics Derives the Entropy Current of Cell Signal Transduction as a Model of a Binary Coding System

Department of Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8315, Japan
Entropy 2018, 20(2), 145; https://doi.org/10.3390/e20020145
Received: 12 January 2018 / Revised: 7 February 2018 / Accepted: 14 February 2018 / Published: 24 February 2018
(This article belongs to the Special Issue Entropy in Signal Analysis)
The analysis of cellular signaling cascades based on information thermodynamics has recently developed considerably. A signaling cascade may be considered a binary code system consisting of two types of signaling molecules that carry biological information, phosphorylated active, and non-phosphorylated inactive forms. This study aims to evaluate the signal transduction step in cascades from the viewpoint of changes in mixing entropy. An increase in active forms may induce biological signal transduction through a mixing entropy change, which induces a chemical potential current in the signaling cascade. We applied the fluctuation theorem to calculate the chemical potential current and found that the average entropy production current is independent of the step in the whole cascade. As a result, the entropy current carrying signal transduction is defined by the entropy current mobility. View Full-Text
Keywords: signal transduction; fluctuation theorem; entropy production rate signal transduction; fluctuation theorem; entropy production rate
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Tsuruyama, T. Information Thermodynamics Derives the Entropy Current of Cell Signal Transduction as a Model of a Binary Coding System. Entropy 2018, 20, 145.

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