Negative contribution of entropy (negentropy) of a non-cahotic system, representing the potential of work, is a source of energy that can be transferred to an internal or inserted subsystem. In this case, the system loses order and its entropy increases. The subsystem increases its energy and can perform processes that otherwise would not happen, like, for instance, the nuclear fusion of inserted deuterons in liquid metal matrix, among many others. The role of positive and negative contributions of free energy and entropy are explored with their constraints. The energy available to an inserted subsystem during a transition from a non-equilibrium to the equilibrium chaotic state, when particle interaction (element of the system) is switched off, is evaluated. A few examples are given concerning some non-ideal systems and a possible application to the nuclear reaction screening problem is mentioned.
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