Entropy Stress and Scaling of Vital Organs over Life Span Based on Allometric Laws
Abstract
:1. Introduction and Literature Review
2. Rationale and Objective
3. Analysis
- Lifetime energy expenditure (LSEE) and entropy generation (LSEGk) of each organ k, where k = B, H, K, L and the remainder R
- Specific lifetime energy expenditure, LSEEM, (kJ/kg body mass) and specific entropy generation, LSEGM, (kJ/{kg body mass K}) whole body
- The % contribution by the each organ k to the overall energy consumption and % contribution by each organ to the total entropy generation of the whole body.
3.1. Life Span Energy Expenditure of Body in Terms of Energy Expenditure of Vital Organs
Organ, k | ck | dk | ek | fk+ | W Contrib* | |
---|---|---|---|---|---|---|
Brain | 0.01100 | 0.76 | 21.620 | −0.14 | 11.93 | 14.0 |
Heart | 0.00630 | 0.98 | 43.113 | −0.12 | 25.89 | 3.31 |
Kidneys | 0.00893 | 0.85 | 33.414 | −0.08 | 23.79 | 6.16 |
Liver | 0.03300 | 0.87 | 33.113 | −0.27 | 10.52 | 9.20 |
Rest, without BHKL | 0.93900 | 1.01 | 1.446 | −0.17 | 0.70 | 49.2 |
Nutrients | Formulae | M, kg/kmol | St.O2, kg/kg | RQ | HHV kJ/kg | HHVO2 kJ/kg O2 | ΔHC° at 37°C MJ/kmol | hf MJ/kmol | s°298 kJ/kmol K | ΔGc° MJ/kmol | ΔGM° MJ/kmol | ΔSc° kJ/kmol K | Metabol. eff. % | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucose | C6H12O6 | 180 | 1.066 | 1.0 | 15630 | 14665 | −2815 | −1260 | 212.0 | −2895 | 1.03 | −1790 | 259.5 | 38.2 |
Fat | C16H32O2 | 256 | 2.869 | 0.7 | 39125 | 13635 | −10035 | −835 | 452.4 | −9840 | 0.98 | −3125 | −630.1 | 32.2 |
Protein or Albumin | C72H112N2O22S (*1) | 1390 | 2.07 | 0.8 | 28893 (*3) | 13944 | −4480 | |||||||
Protein | C4.57H9.03N1.27 O2.25S0.046 (*2) | 119 | 1.54 | 0.8 | 22790 | 14705 | −2720 | −384 | −2665 | 0.98 | −163.8 | 10.4 | ||
Protein [40] | C4.98 H9.8 N1.4O2.5 | 117.3 | 1.413 | 0.83 | 19000 [41] | 13475 |
3.2. Life Span Entropy Generation (LSEG) in Terms of Entropy Generation of Vital Organs
3.3. Availability Analysis
3.3.1. Assumptions
- (a)
- The macronutrients or main nutrient groups CH, F and P are modeled using glucose, palmitic acid, and average amino acids composition respectively.
- (b)
- The ηn, where n=CH, F and P are different for every nutrient but remain constant over time/age.
- (c)
- The ATP, which is equivalent to work in thermodynamics, does not create irreversibility.
- (d)
- Energy requirements are related to body mass mB(t); statistical data on normal growth of body mB (t) with age from the Summary Report 2007, US National Center for Environmental Assessment [33].
- (e)
- Life span of whole species could be defined since the birth and death are well defined; however it is difficult to define the life span of organs. Thus, only extent of degradation of organs is presented in terms of entropy generated during average life span.
- (f)
- The Gibbs free energy change of nutrients during metabolism, ΔGc,n is a function of temperature, pressure and mole fraction is approximately same as ΔGc,n°, i.e., ΔGc,n ≈ ΔGc,n° which implies that nutrients, oxidants, CO2 and H2O exists as pure species in the reactants and products.
- (g)
- In thermodynamic literature, the ratio of varies from 1.0 to 1.02 for most hydrocarbon fuels of general formulae CxHy when lower heat value is used for the enthalpy of combustion of nutrient n. This is consistent with the findings of Brzustowski and Brena, who showed that the ratio of fuel availability to lower heat value ranges from 1.04 to 1.07 [32]. When higher heating values are used for the same fuels, the ratio varies from 0.9 to 0.96 for HC and from 0.98 to 1.03 for CH, and F. Hence,
- (h)
- While general derivations assume that metabolic efficiency depends upon organ k, age (t) and type of nutrients (j) being oxidized, the quantitative results assume a weighted metabolic efficiency independent of organ k and age (t).
3.3.2. Irreversibility of Organs and Heat Transfer from Organs
3.3.3. Lifespan Energy Expenditure and Entropy Generation of Organs and Contribution by Organs to the Body
Parameter | Y | Fk | Remarks |
---|---|---|---|
Life Time Specific Entropy Generation of organ k | Equation (34) | ||
Life Time Entropy Generation contribution by organ k to unit mass of body | Equation (34) with fk replaced by (fk+dk-1) | k,M,st = ckek mB,st (fk+dk−1) | |
Life Time Entropy Generation contribution by organ k to whole body | Equation (34) with fk replaced by (fk+dk) | k, st = ckek mB,st(fk+dk) | |
Life Time Specific metabolic energy release by organ k | Equation (34) | ||
Life Time metabolic energy contribution by organ k to unit mass of body | Equation (34) with fk replaced by (fk+dk-1) | ||
Life Time metabolic energy contribution by organ k to whole body | Equation (34) with fk replaced by (fk+dk) |
4. Results and Discussion
4.1. Nutrient Data
4.2. Growth Data
- Period I: tbirth<t< tst, 1, tst, 1 = 24 yrs, mB, st = 84 kg, {mB/mBst} = {t/tst, 1}°.75
- Period II: 24 < t < 75; mB = mBst = 84 kg, tlife = 75 years
- A short period of small weight loss (period III) after 70 yrs and prior to death was ignored.
4.3. Results
4.3.1. % Contribution by Vital Organs (BHKL) to Overall Metabolic Rates
4.3.2. Growth Correction Factor, F
4.3.3. Specific Basal Metabolic Contribution (SBMRk) by Organ k, tst* = tst,/tlife
4.3.4. Lifespan Specific Energy Expenditure (LSEEM)
% Nutrient consumed for metabolism, CH: F: P = | 55:30:15 |
Computed Fraction of O2 by nutrient “n”, fO2, n. See Equation (24) = | 0.349:0.513: 0.138 |
Average metabolic Efficiency computed by Equation (24) = | 31.3% |
Organ | MJ/(kg body·K) | MJ/kg body |
---|---|---|
Sigma contrib. | Metabolic contrib. | |
Brain | 0.252 | 114 |
Heart | 0.784 | 352 |
Kidney | 0.589 | 266 |
Liver | 1.069 | 480 |
Remainder | 3.610 | 1620 |
Sum | 6.304 | 2832 |
4.3.5. Life Span Organ Entropy Generation
4.3.6. Life span Specific Entropy Generation of Whole Body
4.3.7. Effect of Nutrients
4.3.8. Relation to Life Span
- Looking at data on people living longer than 85 years, heart is cited as #1 cause agreeing with current entropy stress level [2]
- According to current hypothesis, the next organ must be kidney; however cancer is the statistical number 2 cause of death (Figure 2). Recently, Germaine Wong and her colleagues collected data from 3654 Australians within the age group 49–97 years over 10 year period and observed that decreased kidney function leads to an increased risk of developing cancer [38]. Chronic kidney disease is common in people with cardio-vascular disease. Kidney function is also related to progression to cardio-vascular disease; chronic kidney disease is a risk factor in other chronic diseases such as infections and cancer [38].
- Since ROS concentrations are generally higher with increased TB (i.e., metabolism which results in fraction of energy converted into heat) and hence, shorter life span, then decreased TB must lead to prolonged lifespan. “On November 2006, a team of scientists from the Scripps Research Institute reported that transgenic mice which had body temperature 0.3–0.5 °C lower than normal mice indeed lived longer than normal mice.” [39]. Lifespan was 12% longer for males and 20% longer for females. Mice were allowed to eat as much as they wanted. However they had indicated that the effects of such a genetic change in body temperature on longevity are harder to study in humans.
- The third cause happens to be brain as predicted by the MREG model.
- The effect of change in nutrient composition and metabolic efficiency on n (t) are apparent from Equation (17); when n= P, ηn is low (e.g., proteins), and hence n (t) is higher indicating high protein diet leads to highest metabolic heat and irreversibility. It has been shown by Kapahi and his group that life spans of fruit flies are extended by using low protein diet [37].
5. Conclusions
- (1)
- The first and second laws of thermodynamics including availability analyses were applied to the vital organs of biological systems.
- (2)
- It is shown that that the sum of lifetime entropy generation contribution by all the vital organs to each unit body mass is .
- (3)
- The lifetime specific entropy generation of vital organs for 84 kg person is estimated as follows (MJ/ {kg of organ·K}): Bran: 62.4, Heart = 135.4, Kidney: 124.1, Liver: 55.5, Rest of organs: 3.7. The vital organ under most severe stress was found to be heart in agreement with leading cause of natural death.
- (4)
- The total lifetime contribution by all the vital organs to each unit body mass is .
- (5)
- The heart-normalized entropy stress (NESH) values are: Heart: 1.0, Kidney: 0.92, Brain: 0.46, Liver: 0.41, Rest of BS: 0.027. If normalized to rest of body (R), NESR, heart: 37, Kidney: 34, Brain: 17, Liver: 15, Rest of BS: 1.0; so heart will fail first followed by kidney and other organs in order. Supporting data is provided.
- (6)
- It is possible to estimate lifespan entropy stress just by measuring metabolic rate at the standard weight age (after which weight remains constant), and assuming that allometric laws are valid for organs.
- (7)
- Since ROS concentrations are generally higher with increased TB and hence, shorter life span, then decreased TB must lead to prolonged lifespan.
Acknowledgements
Acronyms
ADP | Adenosine di-phosphate |
AMDR/AI | Adequate macronutrient distribution range/Adequate Intake |
ATP | Adenosine tri-phosphate |
BHKL | Brain, heart, kidney, liver |
BMR | Basal Metabolic Rate |
BS | Biological system |
CCE | Cell copy error |
CDC | Center for Disease Control and Prevention |
CH | Carbohydrate |
CR | Calorie restriction diet |
CSA | Chemist Standard Atmosphere, 0 °C, 101 kPa |
DRI | Dietary reference intake |
EER | Energy expenditure requirements |
EER | Estimated energy requirements |
HHV | Higher or gross heating value, |
HHVO2, n | higher heating value per unit mass of stoichiometric oxygen of nutrient n |
LSEG | Lifetime specific entropy generation (J/kg K) |
LSEE | Lifetime specific Energy Expenditure (J/kg) |
LSEH | Lifetime specific energy released as heat |
ME | Metabolic efficiency |
MREG | Modified Rate of Entropy Generation |
NES | Normalized Entropy Stress |
REG | Rate of Entropy Generation |
ROL | Rate of Living Theory |
ROS | Radical Oxygen Species |
SATP | Standard Atmospheric temperature and pressure (25 C, 1 atm) |
SBMR | Specific Basal Metabolic Rate, (W/kg K) |
US FNB | US Food and Nutrition Board |
VLSF | Vital life sustaining functions |
Nomenclature
E | Energy, kJ |
F | Growth Correction factor |
G | Gibbs free energy, kJ |
h | Enthalpy, kJ/kg |
I | Irreversibility I, kJ |
Irreversibility rate, kJ/s | |
m | Mass, kg |
mB | Body mass |
mk | Mass of organ k |
Mass flow rate of nutrient n in organ k | |
Consumption rate of oxygen by nutrient n in organ k | |
P | Protein |
Q | Heat |
Heat transfer rate due to metabolic heat release
at organ k | |
Specific metabolic energy release rate from organ k per unit mass of organ k | |
Energy release rate of organ k contributed to the unit mass of body | |
S | Entropy , kJ/ K |
s | Specific Entropy, kJ/kg K |
TB | Body temperature, K |
t | Time or age |
tst | Time to reach steady weight |
U | Internal energy |
WK | Work delivered by metabolism at organ k |
C° | Gibbs free Energy for combustion |
M° | Gibbs free Energy for metabolism ( with ATP production) |
°ATP | Gibbs free energy |
Greek Symbols
η | metabolic efficiency |
σ | Entropy generation, kJ/K |
σ M,k | Entropy contribution to unit mass of body by whole organ k |
Entropy generation rate per unit body mass (W/kg body mass K) | |
Specific entropy generation rate of organ k (W/{K kg of k}) | |
Ψ | Stream availability, kJ/kg |
νO2,n | Stoichiometric oxygen mass per unit mass of nutrient n |
ηn,k | metabolic efficiency of nutrient n in organ k |
Superscript
0 | Atmospheric conditions |
B,ref | Reference mass for body |
C | Combustion |
k | Organ k |
life | Life Span |
m | Specific referring to unit mass of organ |
M | Specific referring to unit mass of body |
n | Nutrient (n) |
P-R | Difference of value from products to reactants |
J | Nutrient j |
P | Products |
R | Reactants |
St | Steady |
General Notes
Appendix
A1. Alternate Allometric Relations
A2. Integration:
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Annamalai, K.; Silva, C. Entropy Stress and Scaling of Vital Organs over Life Span Based on Allometric Laws. Entropy 2012, 14, 2550-2577. https://doi.org/10.3390/e14122550
Annamalai K, Silva C. Entropy Stress and Scaling of Vital Organs over Life Span Based on Allometric Laws. Entropy. 2012; 14(12):2550-2577. https://doi.org/10.3390/e14122550
Chicago/Turabian StyleAnnamalai, Kalyan, and Carlos Silva. 2012. "Entropy Stress and Scaling of Vital Organs over Life Span Based on Allometric Laws" Entropy 14, no. 12: 2550-2577. https://doi.org/10.3390/e14122550
APA StyleAnnamalai, K., & Silva, C. (2012). Entropy Stress and Scaling of Vital Organs over Life Span Based on Allometric Laws. Entropy, 14(12), 2550-2577. https://doi.org/10.3390/e14122550