Special Issue "Oxidative Stress and Ageing"
Deadline for manuscript submissions: closed (20 May 2013)
Dr. rer. nat. Gregor Drummen
BIO & NANO-SOLUTIONS, Bionanoscience and Bio-Imaging Program, Cellular Stress and Ageing Program, Enniskillener Str. 70, D-33647 Bielefeld, Germany
Fax: +49 322 22407500
Interests: quantum dots; bionanotechnology; two-photon fluorescence imaging; cellular imaging; fluorescence microscopy; nucleic acids; DNA damage; cancer; cell signaling; radiation biology; oxidative stress; lipids and biomembranes; lipid peroxidation
Molecular oxygen is one of those fundamental and essential elements to ensure life and survival of most organisms on the third rock from the sun. Through this molecule, efficient formation of the energy molecule and genetic building block ATP is possible and thus allows the organism to perform work (the thermodynamical definition thereof). However, it is the same molecular oxygen that threatens aerobic life on this planet, because of its potential for radical formation (it is a biradical, although Pauli restricted). From molecular oxygen derived species, Reactive Oxygen Species (ROS), have long been implicated in a multitude of diseases, but not until the discovery that nitric oxide is an essential signaling molecule has the view of the all destructive ROS changed to include normal biological function. To prevent lasting damage, nature ensures that next to antioxidant enzymes that dismutate reactive species, transition metal ion binding molecules that prevent Fenton reactions, food antioxidants that scavenge reactive species and chain-break radical propagation reactions, and a myriad of repair mechanisms that simply repair the damage done by ROS are in place. This balancing biology was what made aerobic life possible in the first place. However, it is also recognized that once the balance between ROS and anti-ROS/repair is disturbed, pathological conditions, such as cancers, inflammation and other diseases occur. Although not a disease in the classical sense, ROS also play an important role in normal ageing processes.
Since developments in this field are so fast, this special issue calls for contributions, original research, mini and full reviews, commentaries, educational papers, and perspectives that address the progress and current standing in this vast field of biology. These include, but are not limited to
- oxidative stress and diseases
- oxidative stress and aging
- biomarkers and diagnostic methods
- oxidative biomarkers
- advances in genetics and molecular mechanisms
- methodology and analysis
- pharmacological or dietetic interventions
- oxidative damage, formation, repair and biological consequences
- current strategies to reduce the development of the oxidative stress in neurodegeneration and ageing
Dr. Gregor Drummen
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
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