Int. J. Mol. Sci. 2013, 14(5), 9475-9486; doi:10.3390/ijms14059475
Article

Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway

1 Department of Respiratory Medicine, the Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400010, China 2 Far Eastern Scientific Center of Physiology and Pathology of Respiration, Russian Academy of Medical Sciences, Blagoveschensk 675000, Russia
* Author to whom correspondence should be addressed.
Received: 24 January 2013; in revised form: 18 March 2013 / Accepted: 16 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Oxidative Stress and Ageing)
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Abstract: Oxidative stress has been implicated as an important contributing factor in the pathogenesis of several pulmonary inflammatory diseases. Previous studies have indicated a relationship between oxidative stress and the attenuation of epithelial tight junctions (TJs). In Human Bronchial Epithelial-16 cells (16HBE), we demonstrated the degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cγ1 (PLCγ1) and the protein kinase Cα (PKCα) signaling cascade.
Keywords: oxidative stress; tight junctions; TRPM2; PLCγ1; PKCα

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MDPI and ACS Style

Xu, R.; Li, Q.; Zhou, X.-D.; Perelman, J.M.; Kolosov, V.P. Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway. Int. J. Mol. Sci. 2013, 14, 9475-9486.

AMA Style

Xu R, Li Q, Zhou X-D, Perelman JM, Kolosov VP. Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway. International Journal of Molecular Sciences. 2013; 14(5):9475-9486.

Chicago/Turabian Style

Xu, Rui; Li, Qi; Zhou, Xiang-Dong; Perelman, Juliy M.; Kolosov, Victor P. 2013. "Oxidative Stress Mediates the Disruption of Airway Epithelial Tight Junctions through a TRPM2-PLCγ1-PKCα Signaling Pathway." Int. J. Mol. Sci. 14, no. 5: 9475-9486.

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