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Serum Oxidant and Antioxidant Status Following an All-Out 21-km Run in Adolescent Runners Undergoing Professional Training—A One-Year Prospective Trial
Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China
Faculty of Education, University of Macau, Macao, China
College of Physical Education, Liaoning Normal University, Dalian 116029, Liaoning, China
Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma 43126, Italy
College of Physical Education, Hebei Normal University, Shijiazhuang 050024, Hebei, China
School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China
* Author to whom correspondence should be addressed.
Received: 6 June 2013; in revised form: 3 July 2013 / Accepted: 8 July 2013 / Published: 22 July 2013
Abstract: This study investigated the 1-year longitudinal effect of professional training in adolescent runners on redox balance during intense endurance exercise. Changes in selected serum oxidant and antioxidant status in response to a 21-km running time trial in 10 runners (15.5 ± 1.3 years) undergoing professional training were evaluated twice in 12 months (pre- and post-evaluation). Venous blood samples were collected immediately before and 4-h following the 21-km run for analysis of serum concentrations of thiobarbituric acid-reactive substances (TBARS), xanthine oxidase (XO), catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC). In pre-evaluation trial, serum TBARS and SOD decreased after the 21-km run (p < 0.05) while XO, GSH, CAT and TAOC were unchanged. In post-evaluation trial, serum TBARS and SOD decreased, whereas XO and CAT increased post-exercise (p < 0.05). Furthermore, pre-exercise serum T-AOC, post-exercise serum XO, CAT, T-AOC (p < 0.05), and GSH (p = 0.057) appeared to be higher than the corresponding pre-evaluation values. The current findings suggest that a professional training regime in adolescent runners is not likely to jeopardize the development of their antioxidant defense. However, uncertainties in the maintenance of redox balance in runners facing increased exercise-induced oxidative stress as a consequence of training-induced enhancement of exercise capacity await further elucidation.
Keywords: adolescent; oxidative stress; antioxidant; endurance exercise
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Tong, T.K.; Kong, Z.; Lin, H.; Lippi, G.; Zhang, H.; Nie, J. Serum Oxidant and Antioxidant Status Following an All-Out 21-km Run in Adolescent Runners Undergoing Professional Training—A One-Year Prospective Trial. Int. J. Mol. Sci. 2013, 14, 15167-15178.
Tong TK, Kong Z, Lin H, Lippi G, Zhang H, Nie J. Serum Oxidant and Antioxidant Status Following an All-Out 21-km Run in Adolescent Runners Undergoing Professional Training—A One-Year Prospective Trial. International Journal of Molecular Sciences. 2013; 14(7):15167-15178.
Tong, Tom K.; Kong, Zhaowei; Lin, Hua; Lippi, Giuseppe; Zhang, Haifeng; Nie, Jinlei. 2013. "Serum Oxidant and Antioxidant Status Following an All-Out 21-km Run in Adolescent Runners Undergoing Professional Training—A One-Year Prospective Trial." Int. J. Mol. Sci. 14, no. 7: 15167-15178.