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Well-Differentiated Papillary Mesothelial Tumor of the Scrotum with Suspicious Invasion

by Soyoung Im, Je Mo Yoo and Uiju Cho

Diagnostics 2024, 14(2), 169; https://doi.org/10.3390/diagnostics14020169 - 11 Jan 2024

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Well-differentiated papillary mesothelial tumor (WDPMT) is a distinct form of mesothelioma with low malignant potential and is mostly found in the peritoneal cavity. It consists of mesothelial cells with papillary structure and bland cytology. We report a rare case of WDPMT with suspicious invasive foci in the tunica vaginalis. WDPMT with invasive foci is known to have a tendency for recurrence. Therefore, careful attention should be given to properly diagnosing and treating this rare entity. Full article

(This article belongs to the Section Pathology and Molecular Diagnostics)

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7 pages, 6424 KiB

Open AccessCase Report

Benign Mesothelial Proliferations of the Tunica Vaginalis Testis

by Claudia Manini, Estíbaliz López-Fernández, Nicola Cruciano, Alessandro Comandone and José I. López

Clin. Pract. 2023, 13(5), 1130-1136; https://doi.org/10.3390/clinpract13050101 - 15 Sep 2023

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Abstract

The correct diagnosis of mesothelial proliferations is a classic problem for pathologists, and one which has important clinical implications. A significant number of such cases appear associated with recurrent hydrocele, as an irritative/reactive response to this condition. The morphological spectrum of mesothelial lesions in this topography is broad, and a set of benign conditions may appear, sometimes with florid gross features and cytologic pseudo-atypia. Here, we present two different examples in which malignancy was initially considered in the differential diagnosis. Full article

(This article belongs to the Special Issue Teaching Pathology Towards Clinics and Practice)

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6 pages, 1131 KiB

Open AccessCase Report

Progression of Well-Differentiated Papillary Mesothelial Tumour to Mesothelioma in a Patient with Ehlers Danlos Syndrome

by Sarita Prabhakaran, Matthew Hussey, Kenneth J. O’Byrne and Sonja Klebe

J. Mol. Pathol. 2021, 2(4), 306-311; https://doi.org/10.3390/jmp2040026 - 29 Oct 2021

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Abstract

Well-differentiated papillary mesothelioma has been renamed well-differentiated papillary mesothelial tumour (WDPMT) in the current WHO classification because all mesotheliomas are now regarded as malignant. WDPMT is now defined as a non-invasive papillary mesothelial proliferation, with retained labelling for BAP1-desirable. The current WHO classification also includes mesothelioma in situ (MIS), which is defined as pre-invasive flat or papillary proliferation of mesothelial cells with a loss of BAP1 or MTAP. WDPMT has been variably defined in the past but was thought to occur more commonly in women and pursue a more indolent course than mesothelioma, but its progression to invasive disease has occasionally been reported. Here, we report a case of a 68-year-old woman with a history of asbestos exposure and an underlying diagnosis of Ehlers Danlos syndrome who was diagnosed with symptomatic WDPMT of the peritoneum that progressed to mesothelioma within two years. On retrospective analysis, the WDPMT showed a loss of BAP1. We suggest that a loss of BAP1 in WDPMT should be reported, since these lesions may show aggressive behaviour, and that they may best be regarded as similar to mesothelioma in situ. Full article

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4 pages, 7067 KiB

Open AccessInteresting Images

Massive Relief: Papillary Adenoma of the Lung in Asymptomatic Former Smoker Patient

by Jelena Stojšić, Marko Popović, Federica Pezzuto and Jelena Marković

Diagnostics 2020, 10(11), 906; https://doi.org/10.3390/diagnostics10110906 - 6 Nov 2020

Cited by 4 | Viewed by 3537

Abstract

Benign epithelial tumors of the lung are uncommon and can represent a diagnostic challenge. Herein, we describe one such emblematic case. A 59-year-old former smoker male was admitted to the hospital complaining of cough for a long time. A radiological examination showed a centrally excavated mass strictly connected to the visceral pleura. The patient underwent tumorectomy. At gross examination, the tumor was composed of solid and cystic areas containing clear liquid. Histological examination highlighted a sub-pleural encapsulated tumor, with foci of capsular invasion, characterized by a single layer of columnar and cuboidal epithelial cells lining moderately cellular fibro-vascular cores. A wide spectrum of immunohistochemical markers was performed. The final diagnosis was suggestive of a peripheral pulmonary papillary tumor of undetermined malignant potential. At the last follow-up, six years after surgery, no recurrence or metastases were described. Reporting this case, we would like to point out the existence of these rare entities that should be taken into account in the diagnostic process, thus avoiding potential misdiagnosis. Moreover, the presence of capsular invasion should be better investigated in order to reconsider the exact terminology of the tumor and the classification of its malignant potential. Full article

(This article belongs to the Collection Interesting Images)

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12 pages, 2222 KiB

Open AccessArticle

Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma

by Raunak Shrestha, Noushin Nabavi, Stanislav Volik, Shawn Anderson, Anne Haegert, Brian McConeghy, Funda Sar, Sonal Brahmbhatt, Robert Bell, Stephane Le Bihan, Yuzhuo Wang, Colin Collins and Andrew Churg

Cancers 2020, 12(6), 1568; https://doi.org/10.3390/cancers12061568 - 13 Jun 2020

Cited by 26 | Viewed by 7022

Abstract

Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial proliferation that is most commonly encountered as an incidental finding in the peritoneal cavity. There is controversy in the literature about whether WDPM is a neoplasm or a reactive process and, if neoplastic, whether it is a variant or precursor of epithelial malignant mesothelioma or is a different entity. Using whole exome sequencing of five WDPMs of the peritoneum, we have identified distinct mutations in EHD1, ATM, FBXO10, SH2D2A, CDH5, MAGED1, and TP73 shared by WDPM cases but not reported in malignant mesotheliomas. Furthermore, we show that WDPM is strongly enriched with C > A transversion substitution mutations, a pattern that is also not found in malignant mesotheliomas. The WDPMs lacked the alterations involving BAP1, SETD2, NF2, CDKN2A/B, LASTS1/2, PBRM1, and SMARCC1 that are frequently found in malignant mesotheliomas. We conclude that WDPMs are neoplasms that are genetically distinct from malignant mesotheliomas and, based on observed mutations, do not appear to be precursors of malignant mesotheliomas. Full article

(This article belongs to the Special Issue Malignant Mesothelioma)

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