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Search Results (3,959)

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27 pages, 3352 KB  
Review
Recent Advances in Triboelectric Nanogenerators for Biomedical and Cardiovascular Monitoring
by Amit Sarode, Jegan Rajendran and Gymama Slaughter
Materials 2026, 19(8), 1647; https://doi.org/10.3390/ma19081647 (registering DOI) - 20 Apr 2026
Abstract
Triboelectric nanogenerators (TENGs) have emerged as versatile self-powered platforms for wearable and implantable biomedical sensing, offering an alternative to battery-dependent electronic devices. By converting biomechanical energy from physiological motion into electrical signals, TENGs enable simultaneous energy harvesting and active sensing within flexible, lightweight, [...] Read more.
Triboelectric nanogenerators (TENGs) have emerged as versatile self-powered platforms for wearable and implantable biomedical sensing, offering an alternative to battery-dependent electronic devices. By converting biomechanical energy from physiological motion into electrical signals, TENGs enable simultaneous energy harvesting and active sensing within flexible, lightweight, and biocompatible architectures. This review summarizes recent advances from 2020 to 2025 in triboelectric nanogenerator (TENG)-based cardiovascular monitoring. The discussion focuses on material systems, device configurations, sensing mechanisms, and applications including pulse detection and cuffless blood pressure estimation. Representative studies are compared to highlight emerging trends in wearable and self-powered sensing technologies. However, differences in experimental conditions, anatomical sites, calibration methods, and signal-processing approaches limit direct comparison of reported performance. In addition, challenges such as subject-specific calibration, motion artifacts, and limited clinical validation remain. Overall, this review highlights current progress and outlines key challenges for future development and translation of TENG-based cardiovascular monitoring systems. Full article
(This article belongs to the Section Advanced Nanomaterials and Nanotechnology)
20 pages, 4898 KB  
Article
Highly Robust and Multimodal PVA/Aramid Nanofiber/MXene Organogel Sensors for Advanced Human–Machine Interfaces
by Guofan Zeng, Leiting Liao, Zehong Wu, Jinye Chen, Peidi Zhou, Yihan Qiu and Mingcen Weng
Biosensors 2026, 16(4), 229; https://doi.org/10.3390/bios16040229 (registering DOI) - 20 Apr 2026
Abstract
Flexible and wearable electronics require soft sensing materials that balance mechanical compliance, stable signal transduction, and durability for human–machine interfaces (HMIs). To address the limitations of single-filler systems, we propose a poly(vinyl alcohol) (PVA)/aramid nanofiber (ANF)/MXene organogel (PAM) as a multifunctional soft platform. [...] Read more.
Flexible and wearable electronics require soft sensing materials that balance mechanical compliance, stable signal transduction, and durability for human–machine interfaces (HMIs). To address the limitations of single-filler systems, we propose a poly(vinyl alcohol) (PVA)/aramid nanofiber (ANF)/MXene organogel (PAM) as a multifunctional soft platform. This design integrates a PVA physically crosslinked network with ANF for mechanical reinforcement and MXene for electrical functionality. The optimized PAM composite exhibits outstanding mechanical properties, including a fracture stress of 2931 kPa, a fracture strain of 676%, and a fracture toughness of 9.04 MJ m−3. Importantly, PAM serves as a single material platform configurable into three sensing modalities. The resistive strain sensor achieves a gauge factor of 3.1 over 10–100% strain and enables the reliable recognition of human joint movements and gestures. The capacitive pressure sensor delivers a sensitivity of 0.298 kPa−1, rapid response/recovery times of 30/10 ms, and is integrated with a wireless module to control a smart car. Furthermore, the PAM-based triboelectric nanogenerator (TENG) delivers excellent electrical outputs (Voc = 123 V, Isc = 0.52 μA, Qsc = 58 nC) and functions as a self-powered smart handwriting pad, achieving a machine-learning-based recognition accuracy of 97.6%. This work demonstrates the immense potential of the PAM organogel for advanced, self-powered HMIs. Full article
(This article belongs to the Special Issue Flexible and Stretchable Biosensors)
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24 pages, 2768 KB  
Article
Enhancing Wearable-Based Elderly Activity Recognition Through a Hybrid Deep Residual Network
by Sakorn Mekruksavanich and Anuchit Jitpattanakul
Mach. Learn. Knowl. Extr. 2026, 8(4), 107; https://doi.org/10.3390/make8040107 - 18 Apr 2026
Viewed by 13
Abstract
The rapid growth of the elderly population worldwide demands reliable activity recognition technologies to support independent living and continuous health supervision. However, conventional wearable sensor-based human activity recognition (HAR) techniques often fail to capture the complex temporal behaviour and subtle motion patterns characteristic [...] Read more.
The rapid growth of the elderly population worldwide demands reliable activity recognition technologies to support independent living and continuous health supervision. However, conventional wearable sensor-based human activity recognition (HAR) techniques often fail to capture the complex temporal behaviour and subtle motion patterns characteristic of the elderly. To address these limitations, this study introduces a hybrid deep residual architecture—CNN-CBAM-BiGRU—that integrates convolutional neural networks (CNNs), the convolutional block attention module (CBAM), and bidirectional gated recurrent units (BiGRUs) to improve activity recognition using inertial measurement unit (IMU) data. In the proposed CNN-CBAM-BiGRU framework, CNN layers automatically derive representative features from raw sensor signals, CBAM applies adaptive channel and spatial attention to highlight informative patterns, and BiGRU captures long-range temporal relationships within activity sequences. The approach was evaluated on three benchmark datasets designed for elderly populations—HAR70+, HARTH, and SisFall—covering daily activities and fall events. The proposed model consistently outperforms existing methods across all datasets, achieving accuracies exceeding 96%, F1-scores above 93%, and a fall detection recall of 93.74%, confirming its robustness and suitability for safety-critical monitoring applications. Class-level evaluation indicates excellent recognition of static postures and consistent performance for dynamic actions. Convergence analysis further confirms efficient learning with limited overfitting across datasets. The proposed framework thus provides a robust and accurate solution for wearable-based elderly activity recognition, with strong potential for deployment in fall detection, health monitoring, and ambient assisted living systems. Full article
(This article belongs to the Special Issue Sustainable Applications for Machine Learning—2nd Edition)
39 pages, 1460 KB  
Review
Modernizing Livestock Operations: Smart Feedlot Technologies and Their Impact
by Son D. Dao, Amirali Khodadadian Gostar, Ruwan Tennakoon, Wei Qin Chuah and Alireza Bab-Hadiashar
Animals 2026, 16(8), 1244; https://doi.org/10.3390/ani16081244 - 18 Apr 2026
Viewed by 68
Abstract
Smart feedlots are increasingly adopting Precision Livestock Farming technologies to enable continuous, individual-animal monitoring and more proactive management in intensive beef production systems. This narrative review synthesises evidence from approximately 350 academic publications, of which 117 are formally cited, complemented by industry deployments [...] Read more.
Smart feedlots are increasingly adopting Precision Livestock Farming technologies to enable continuous, individual-animal monitoring and more proactive management in intensive beef production systems. This narrative review synthesises evidence from approximately 350 academic publications, of which 117 are formally cited, complemented by industry deployments and the authors’ experience in smart feedlot system development. We cover enabling digital infrastructure (power, sensing networks, wireless connectivity, and gateways), animal identification and sensing (RFID, automated weighing, wearables, and pen-side sensors), machine vision (RGB, thermal, and multispectral imaging from fixed and mobile platforms), and AI-based analytics and decision support for health, welfare, performance, and environmental management. Across the literature, key components have progressed beyond proof-of-concept toward operation under commercial constraints. Reported outcomes include reduced reliance on routine pen-rider observation and yard handling, earlier triage of emerging morbidity risk and behavioural change, and more standardised welfare auditing. Vision-based methods are repeatedly validated against trained human scorers in both on-farm and abattoir contexts, while automated weighing and image-based liveweight estimation support higher-frequency growth monitoring with low single-digit percentage error in representative studies. Precision feeding and targeted supplementation are associated with improved feed utilisation and reduced resource wastage, although effectiveness and adoption vary across animal classes and production stages. We identify priorities for robust, scalable deployment: resilient communications in harsh environments, appropriate edge–cloud partitioning under intermittent connectivity, and interoperable multi-sensor data fusion to deliver trustworthy alerts and actionable insights. Persistent barriers remain cost, durability, maintenance burden, integration and interoperability, data governance, and workforce capability. Full article
(This article belongs to the Section Animal System and Management)
42 pages, 3651 KB  
Review
Recent Progress of Structural Design, Fabrication Processes, and Applications of Flexible Acceleration Sensors
by Yuting Wang, Zhidi Chen, Peng Chen, Jie Mei, Jiayue Kuang, Chang Li, Zhijun Zhou and Xiaobo Long
Sensors 2026, 26(8), 2499; https://doi.org/10.3390/s26082499 - 17 Apr 2026
Viewed by 135
Abstract
Flexible acceleration sensors demonstrate revolutionary potential in healthcare, structural vibration monitoring, and consumer electronics owing to their unique conformal adhesion capability and mechanical adaptability. However, current academic research presents two distinct paradigms for realizing flexibility: one is the hybridly flexible sensor, which incorporates [...] Read more.
Flexible acceleration sensors demonstrate revolutionary potential in healthcare, structural vibration monitoring, and consumer electronics owing to their unique conformal adhesion capability and mechanical adaptability. However, current academic research presents two distinct paradigms for realizing flexibility: one is the hybridly flexible sensor, which incorporates traditional micro-electro-mechanical System (MEMS) acceleration sensor chips with flexible packaging/substrates; the other is the intrinsically flexible sensor, whose sensing unit and substrate are entirely composed of flexible materials enabled by microstructural design. This review first analyzes the fundamental differences and design challenges between these two flexible architectures. It then systematically elucidates five core sensing mechanisms—capacitive, piezoresistive, triboelectric, piezoelectric, and electromagnetic—comparing their working principles, material systems, structural designs, and performance metrics. Among these, piezoelectric and triboelectric types exhibit distinctive advantages in self-powering capability, whereas resistive and capacitive approaches offer greater ease of integration. Furthermore, the applications of intrinsically flexible acceleration sensors in structural health monitoring, wearable devices, automotive safety, and other fields are discussed, with particular emphasis on their unique strengths in real-time vibration monitoring. Finally, the review summarizes existing challenges, such as the trade-off between sensitivity and flexibility, and provides theoretical insights to guide future innovations in intrinsically flexible acceleration sensor technology. Full article
(This article belongs to the Special Issue 2D Materials for Advanced Sensing Technology)
19 pages, 9440 KB  
Article
Comparative Assessment of PPG-Derived HRV Using MAX30102 Sensor and Analog Circuitry with ADS1115 ADC
by Jesús E. Miranda-Vega, Rafael I. Ayala-Figueroa, Yanet Villarreal-González and Pedro A. Escarcega-Zepeda
Sensors 2026, 26(8), 2487; https://doi.org/10.3390/s26082487 - 17 Apr 2026
Viewed by 98
Abstract
Heart rate variability (HRV) is a key physiological marker for autonomic nervous system function and cardiovascular health. Photoplethysmography (PPG) is commonly used to derive HRV metrics in wearable and low-cost monitoring systems. This study presents a comparative assessment of basic HRV metrics obtained [...] Read more.
Heart rate variability (HRV) is a key physiological marker for autonomic nervous system function and cardiovascular health. Photoplethysmography (PPG) is commonly used to derive HRV metrics in wearable and low-cost monitoring systems. This study presents a comparative assessment of basic HRV metrics obtained from a MAX30102 optical sensor and a custom analog circuitry with an ADS1115 analog-to-digital converter (ADC). Both measurement pathways were carefully aligned using analog high-pass and low-pass filters and a consistent digital filtering pipeline, ensuring that the frequency bands relevant to HRV were preserved. PPG signals were recorded simultaneously, and inter-beat intervals were extracted to calculate the Standard Deviation of NN intervals (SDNN), Root Mean Square of Successive Differences (RMSSD), and Percentage of successive NN intervals >50 ms (pNN50) across multiple 30-s windows. Bland–Altman analysis was employed to evaluate agreement between the two methods. Results indicate that the analog circuit with an ADS1115 achieves comparable HRV basic metrics to the MAX30102 sensor, with improved Signal-to-Noise Ratio (SNR) due to high-resolution ADC and low-noise analog amplification. These findings demonstrate that a carefully designed analog acquisition system can reliably reproduce HRV basic parameters from PPG signals, providing an alternative approach for low-cost, flexible biosensing platforms. Full article
(This article belongs to the Special Issue Wearable Sensor for Health Monitoring)
39 pages, 4762 KB  
Review
Event-Based Vision at the Edge: A Review
by Michael Middleton, Teymoor Ali, Epifanios Baikas, Hakan Kayan, Basabdatta Sen Bhattacharya, Elena Gheorghiu, Mark Vousden, Charith Perera, Oliver Rhodes and Martin A. Trefzer
Brain Sci. 2026, 16(4), 422; https://doi.org/10.3390/brainsci16040422 - 17 Apr 2026
Viewed by 92
Abstract
Spiking Neural Networks (SNNs) executed on neuromorphic hardware promise energy-efficient, low-latency inference well-suited to edge deployment in size, weight, and power-constrained environments such as autonomous vehicles, wearable devices, and unmanned aerial platforms. However, a coherent research pathway to deployment of neuromorphic devices remains [...] Read more.
Spiking Neural Networks (SNNs) executed on neuromorphic hardware promise energy-efficient, low-latency inference well-suited to edge deployment in size, weight, and power-constrained environments such as autonomous vehicles, wearable devices, and unmanned aerial platforms. However, a coherent research pathway to deployment of neuromorphic devices remains elusive. This paper presents a structured review and position on the state of SNN-based vision across four interconnected dimensions: network architectures, training methodologies, event-based datasets and simulation techniques, and neuromorphic computing hardware. We survey the evolution from shallow convolutional SNNs to spiking Transformers and hybrid designs which leverage the advantages of SNNs and conventional artificial neural networks. We also examine surrogate gradient training and ANN-to-SNN conversion approaches, catalogue real-world and simulated event-based datasets, and assess the landscape of neuromorphic platforms ranging from rigid mixed-signal architectures to fully-configurable digital systems. Our analysis reveals that while each area has matured considerably in isolation, critical integration challenges persist. In particular, event-based datasets remain scarce and lack standardisation, training methodologies introduce systematic gaps relative to deployment hardware, and access to neuromorphic platforms is restricted by proprietary toolchains and limited development kit availability. We conclude that bridging these integration gaps, rather than advancing individual components alone, represents the most important and least addressed work required to realise the potential of SNN-based vision at the edge. Full article
25 pages, 1098 KB  
Review
Applications of Heart Rate Variability Metrics in Wearable Sensor Technologies: A Comprehensive Review
by Emi Yuda
Electronics 2026, 15(8), 1707; https://doi.org/10.3390/electronics15081707 - 17 Apr 2026
Viewed by 91
Abstract
Heart rate variability (HRV) has emerged as a key biomarker for assessing autonomic nervous system activity, stress, fatigue, and emotional states. With the rapid development of wearable sensor technologies, HRV analysis has expanded from clinical environments to real-world, continuous monitoring. This review summarizes [...] Read more.
Heart rate variability (HRV) has emerged as a key biomarker for assessing autonomic nervous system activity, stress, fatigue, and emotional states. With the rapid development of wearable sensor technologies, HRV analysis has expanded from clinical environments to real-world, continuous monitoring. This review summarizes current applications of HRV metrics in wearable devices, including fitness tracking, mental stress assessment, sleep quality evaluation, and early detection of physiological or psychological disorders. Recent advances in photoplethysmography (PPG)-based HRV estimation have enabled noninvasive and user-friendly measurement, though challenges remain in accuracy under motion and variable environmental conditions. We also discuss methodological considerations, such as artifact correction, data segmentation, and the integration of HRV with other biosignals for multimodal analysis. Emerging research suggests that combining HRV with metrics such as respiration rate, skin conductance, and accelerometry can enhance robustness and interpretability in dynamic settings. Finally, future directions are proposed toward personalized health analytics, emotion-aware computing, and real-time adaptive feedback systems. This review highlights the growing potential of wearable HRV analysis as a foundation for preventive healthcare and human–machine symbiosis. Full article
(This article belongs to the Special Issue Smart Devices and Wearable Sensors: Recent Advances and Prospects)
16 pages, 7078 KB  
Article
FPGA Implementation of a Radar-Based Fall Detection System Using Binarized Convolutional Neural Networks
by Hyeongwon Cho, Soongyu Kang and Yunho Jung
Sensors 2026, 26(8), 2469; https://doi.org/10.3390/s26082469 - 17 Apr 2026
Viewed by 124
Abstract
As the number of elderly individuals living alone increases, the risk of fall-related accidents correspondingly rises, underscoring the need for rapid fall detection systems. Because falls are difficult to predict in terms of location, detection systems must be deployed in a distributed manner, [...] Read more.
As the number of elderly individuals living alone increases, the risk of fall-related accidents correspondingly rises, underscoring the need for rapid fall detection systems. Because falls are difficult to predict in terms of location, detection systems must be deployed in a distributed manner, which in turn requires compact and low-power implementations. Unlike camera sensors, radar sensors do not raise privacy concerns and are not limited by line-of-sight constraints. Moreover, compared with wearable sensors, radar enables continuous monitoring without user intervention. However, prior radar-based approaches incur high computational complexity, leading to increased power consumption and larger hardware area, thereby necessitating efficient hardware design. This paper proposes a lightweight fall detection system based on continuous-wave (CW) radar and a binarized convolutional neural network (BCNN). Radar signals are preprocessed using short-time Fourier transform (STFT) to generate binary spectrograms, which are then fed into a BCNN-based classification network. The proposed system performs binary classification of five fall activities and seven non-fall activities with an accuracy of 96.1%. The preprocessing module and classification network were implemented as hardware accelerators and integrated with a microprocessor in a system-on-chip (SoC) architecture on a field-programmable gate array (FPGA). Compared with the software implementation, the proposed hardware achieved speedups of 387.5× and 86.7× for the preprocessing and classification modules, respectively. Furthermore, the overall system processing time was 2.58 ms, corresponding to an 89.5× speedup over the software baseline. Full article
(This article belongs to the Special Issue Sensor-Based Movement Signal Acquisition, Processing and Analysis)
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15 pages, 3786 KB  
Article
A Flexible Copper Electrode Array for High-Density Surface Electromyography
by Chaoxin Li, Chenghong Lu, Jiuqiang Li and Kai Guo
Bioengineering 2026, 13(4), 467; https://doi.org/10.3390/bioengineering13040467 - 16 Apr 2026
Viewed by 177
Abstract
Precise monitoring of forearm muscle groups is crucial for decoding motor intentions in human–machine interfaces (HMIs) and rehabilitation. However, traditional surface electromyography (sEMG) electrodes face significant challenges in densely packed muscle regions with large skin deformations, leading to severe signal crosstalk and unstable [...] Read more.
Precise monitoring of forearm muscle groups is crucial for decoding motor intentions in human–machine interfaces (HMIs) and rehabilitation. However, traditional surface electromyography (sEMG) electrodes face significant challenges in densely packed muscle regions with large skin deformations, leading to severe signal crosstalk and unstable contact. Here, we report a flexible, low-cost 16-channel copper electrode array system designed for the high-density monitoring of multiple forearm muscle activities. Through a facile fabrication process, rigid copper is transformed into a conformable sensing interface. The optimized serpentine interconnects endow the array with excellent stretchability and effectively isolate motion-induced stress, ensuring high-quality signal acquisition under complex deformations. The high-density 2 × 8 array enables the spatiotemporal mapping of distributed flexor and extensor muscle groups. Integrated with a customized wireless data acquisition system, the array successfully demonstrates real-time, multi-channel sEMG monitoring of various hand movements (e.g., fist clenching, wrist flexion/extension), clearly revealing specific muscle activation patterns. This low-cost, high-performance flexible sensor array provides a highly promising tool for complex gesture decoding, electromyographic imaging, and next-generation wearable HMIs. Full article
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13 pages, 502 KB  
Article
Test–Retest Reliability of Heart Rate and Parasympathetic Modulation Indices Across Exercise and Recovery Phases in Athletes
by Süleyman Ulupınar, Serhat Özbay, Cebrail Gençoğlu, İzzet İnce, Salih Çabuk, Özgür Bakar, Abdullah Demirli and Kaan Kaya
Sensors 2026, 26(8), 2448; https://doi.org/10.3390/s26082448 - 16 Apr 2026
Viewed by 188
Abstract
This study examined the within-session (same-day) test–retest reliability of heart rate (HR) and parasympathetic modulation, assessed using the root mean square of successive differences (RMSSD), across exercise and recovery phases in trained soccer players. Twenty-seven male soccer players (age: 24.9 ± 3.7 years) [...] Read more.
This study examined the within-session (same-day) test–retest reliability of heart rate (HR) and parasympathetic modulation, assessed using the root mean square of successive differences (RMSSD), across exercise and recovery phases in trained soccer players. Twenty-seven male soccer players (age: 24.9 ± 3.7 years) completed a standardized soccer training session. HR and RMSSD were recorded using an ECG-based chest-strap monitor at rest, pre-exercise, and at ~10–20 min, 1 h, and 3 h post-exercise. At each time point, two consecutive 5 min seated recordings were obtained under identical conditions. Test–retest reliability was evaluated using intraclass correlation coefficients (ICC(3,1)), standard error of measurement (SEM), coefficient of variation (CV%), minimal detectable change (MDC95), paired-samples t-tests, and Hedges’ g effect sizes. HR demonstrated excellent reliability across all time points (ICC = 0.980–0.994; SEM = 0.87–1.25 bpm; CV% = 1.33–3.70%). RMSSD showed excellent reliability at rest (ICC = 0.944) and pre-exercise (ICC = 0.918), moderate reliability during early recovery (~10–20 min; ICC = 0.551), and good reliability at 1 h (ICC = 0.826) and 3 h post-exercise (ICC = 0.873). No significant systematic differences were observed between test and retest measurements (all p > 0.05), and effect sizes were trivial. These findings indicate that within-session reliability of HR remains consistently high across exercise and recovery phases, whereas RMSSD reliability varies according to measurement timing, particularly during early recovery. Full article
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27 pages, 4304 KB  
Review
Towards Intelligent Pain Monitoring Systems: A Survey of Recent Technologies and Methods
by Atif Naseer, Nahla Tayyib and Sidra Rashid
Sensors 2026, 26(8), 2447; https://doi.org/10.3390/s26082447 - 16 Apr 2026
Viewed by 254
Abstract
Pain is a profoundly stressful experience that significantly impacts an individual’s daily life. In many situations, people can express the intensity of pain via some observable physical actions like crying or shouting. However, in cases where the patient is non-communicative, they cannot convey [...] Read more.
Pain is a profoundly stressful experience that significantly impacts an individual’s daily life. In many situations, people can express the intensity of pain via some observable physical actions like crying or shouting. However, in cases where the patient is non-communicative, they cannot convey their feelings through these actions. In both scenarios, automatically monitoring pain intensity using technology presents a considerable challenge. In the literature, researchers have presented numerous techniques for automatic pain monitoring using multiple approaches. This technological survey paper aims to provide an overview of current advancements in the field of automatic pain monitoring. In this paper, we present a taxonomy that summarizes our survey on the utilization of technology areas for monitoring pain automatically. Those technologies are based on Internet of Things (IoT), computer vision, and multimodal techniques. These technologies utilize various modalities, including physiological signals, facial expressions, vocalizations, and behavioral patterns, to detect and quantify pain. The paper discusses the advantages and limitations of each modality, as well as the challenges faced in developing accurate and reliable pain monitoring systems. Additionally, the paper surveys the current state of research in this field, including the development of machine learning algorithms and wearable devices for pain monitoring. Overall, this paper provides a comprehensive overview of the current state of automatic pain monitoring technology and highlights areas for future research and development. This paper also creates a keyword map that will serve as a valuable resource for researchers, enabling them to refine their investigations by identifying frequently used terms and emerging trends within each domain. Full article
(This article belongs to the Section Biomedical Sensors)
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24 pages, 5998 KB  
Article
A Wearable System for Real-Time Fall Detection on Resource-Constrained Devices
by Timothy Malche, Govind Murari Upadhyay, Sumegh Tharewal, Vipin Balyan, Vikash Kumar Mishra, Gunjan Gupta and Pramod Kumar Soni
Future Internet 2026, 18(4), 211; https://doi.org/10.3390/fi18040211 - 16 Apr 2026
Viewed by 278
Abstract
In this study, we propose a wearable fall detection system that combines wearable sensors, TinyML model, and IoT-based communication for real-time monitoring and detection of falls. The system is designed for resource-constrained IoT devices where memory, power, and processing capacity are limited. The [...] Read more.
In this study, we propose a wearable fall detection system that combines wearable sensors, TinyML model, and IoT-based communication for real-time monitoring and detection of falls. The system is designed for resource-constrained IoT devices where memory, power, and processing capacity are limited. The system works by collecting body motion data using accelerometer sensors placed on the human body. The data is then processed using a feedforward neural network trained on preprocessed signals. The trained model is quantized so that it can run on low-power embedded hardware with small memory size. The model performs inference directly on the device. This reduces latency and avoids sending raw sensor data to the cloud. When a fall is detected, the result is sent through Bluetooth to a gateway. The gateway forwards the data to a cloud server using the MQTT protocol. The cloud stores the data and supports monitoring and analysis. The experimental results show that the quantized TinyML model achieves 98.40% accuracy with more than 80% F1-score and more than 99% recall. The deployed model uses only ∼5 KB of RAM and ∼40 KB of flash memory. The inference time is 7 ms per class. These results show that wearable sensing with quantized TinyML models and IoT communication can provide fast and reliable fall detection for real-world safety monitoring systems. Full article
(This article belongs to the Special Issue Artificial Intelligence-Enabled Smart Healthcare)
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18 pages, 1217 KB  
Article
Detect and Repair: Robust Self-Supervised Wearable Sensing Under Missing Modalities
by Aboul Hassane Cisse and Shoya Ishimaru
Sensors 2026, 26(8), 2419; https://doi.org/10.3390/s26082419 - 15 Apr 2026
Viewed by 198
Abstract
Wearable sensor systems are being increasingly deployed in real-world environments to monitor human activities and cognitive states. However, such systems frequently suffer from degraded or missing sensor modalities due to occlusions, energy constraints, or hardware failures. In this work, we introduce CognifySSL v2.0, [...] Read more.
Wearable sensor systems are being increasingly deployed in real-world environments to monitor human activities and cognitive states. However, such systems frequently suffer from degraded or missing sensor modalities due to occlusions, energy constraints, or hardware failures. In this work, we introduce CognifySSL v2.0, a self-supervised learning framework designed to detect and repair missing modalities in real time under simulated real-world missing-modality conditions. The model combines contrastive and masked modeling objectives across multiple physiological and motion signals (e.g., IMU, ECG, EDA) using a fusion architecture with dropout simulation. Evaluation on WESAD demonstrated effective multimodal detection and reconstruction under missing-modality conditions, while experiments on MobiAct validated unimodal robustness and representation learning under sensor dropout. We released our code and interactive visualization dashboard to support reproducibility and future research on robust multimodal fusion. Full article
23 pages, 1350 KB  
Review
Precision and Personalized Medicine in Transdermal Drug Delivery Systems: Integrating AI Approaches
by Sesha Rajeswari Talluri, Brian Jeffrey Chan and Bozena Michniak-Kohn
J. Pharm. BioTech Ind. 2026, 3(2), 9; https://doi.org/10.3390/jpbi3020009 - 15 Apr 2026
Viewed by 179
Abstract
Personalized transdermal drug delivery systems (TDDS) represent a transformative approach in precision medicine by enabling patient-specific, non-invasive, and controlled therapeutic administration. Conventional transdermal patches are limited by fixed dosing, passive diffusion, and interindividual variability in skin permeability and metabolism, often leading to suboptimal [...] Read more.
Personalized transdermal drug delivery systems (TDDS) represent a transformative approach in precision medicine by enabling patient-specific, non-invasive, and controlled therapeutic administration. Conventional transdermal patches are limited by fixed dosing, passive diffusion, and interindividual variability in skin permeability and metabolism, often leading to suboptimal therapeutic outcomes. Recent advances in materials science, nanotechnology, microneedle engineering, and digital health have enabled the development of next-generation personalized TDDS capable of programmable, adaptive, and feedback-controlled drug release. Smart wearable patches integrating biosensors, microfluidics, microneedles, and wireless connectivity allow real-time monitoring of physiological and biochemical parameters, enabling closed-loop drug delivery tailored to individual metabolic profiles. Nanocarriers such as lipid nanoparticles, polymeric nanoparticles, and stimuli-responsive hydrogels further enhance drug stability, penetration, and controlled release, while 3D-printing technologies facilitate patient-specific customization of patch geometry, drug loading, and release kinetics. Artificial intelligence (AI) and machine learning tools are increasingly being employed to predict drug permeation behavior, optimize enhancer combinations, and personalize dosing regimens based on pharmacogenomic and pharmacokinetic data. Despite these advances, regulatory complexity, manufacturing standardization, long-term biocompatibility, and cybersecurity considerations remain critical challenges for clinical translation. This review highlights recent innovations in personalized TDDS, discusses their clinical potential, and examines regulatory and technological barriers. Collectively, these emerging smart transdermal platforms offer a promising pathway toward adaptive, patient-centered therapeutics that can significantly improve treatment efficacy, safety, and compliance. Future research should focus on integrating multimodal biosensing, advanced biomaterials, scalable manufacturing strategies, and robust regulatory frameworks to enable clinically validated, fully autonomous transdermal systems that can dynamically adapt to real-time patient needs in diverse therapeutic settings. Full article
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