Search Results (3)

This article covers the overall design hardware choices for the prototyping activities for the DUCK (Detector system of Unusual Cosmic ray casKades). The primary goal of the DUCK system is to verify the existence of the unusual cosmic events reported by other collaborations and to look at the possibilities of adding innovations to the EAS (Extensive Atmospheric Shower) analysis methods of the EAS disk measurements at the observation level. Additionally, design and construction of the system provide educational experience to the students involved in the project and are developing the research capabilities of the university campus. The prototyping process has helped to choose between various design solutions in the process of optimizing of the individual detector components. Full article

The article describes the development, design, and upcoming construction and deployment of core modules of DUCK (Detector system of Unusual Cosmic-ray casKades), a cosmic-rays detector system aimed to verify and further study the latest advances in the cosmic-rays field and participate in the international collaborations searching for new types of events. The primary scientific goal for the DUCK project will be an independent verification of the detection of ‘unusual’ cosmic ray events by the Horizon-T detector system. A detailed study of events of this type is a vital step towards understanding the nature of cosmic rays, their origins, and details of interaction with the nuclei in the atmosphere. Further operations as part of the CREDO collaboration will contribute to the continued monitoring of the cosmic events. Additional intellectual value includes the design of the fast detection system with high timing resolution for cosmic events detection and the study of the temporal structure of extensive air showers that would also contribute to the current simulations. All the steps are conducted with student involvement and advance excellence in providing students with real research experience and competitive knowledge. Full article

Vascular calcification (VC) is a pathological event caused by the unusual deposition of minerals in the vascular system, representing the leading cause of cardiovascular mortality in chronic kidney disease (CKD). In CKD, the deregulation of calcium and phosphate metabolism, along with the effect of several uremic toxins, act as key processes conveying altered mineralization. In this work, we tested the ability of lanthionine, a novel uremic toxin, to promote calcification in human endothelial cell cultures (Ea.hy926). We evaluated the effects of lanthionine, at a concentration similar to that actually detected in CKD patients, alone and under pro-calcifying culture conditions using calcium and phosphate. In pro-calcific culture conditions, lanthionine increased both the intracellular and extracellular calcium content and induced the expression of Bone Morphogenetic Protein 2 (BMP2) and RUNX Family Transcription Factor 2 (RUNX2). Lanthionine treatment, in pro-calcifying conditions, raised levels of tissue-nonspecific alkaline phosphatase (ALPL), whose expression also overlapped with Dickkopf WNT Signaling Pathway Inhibitor 1 (DKK1) gene expression, suggesting a possible role of the latter gene in the activation of ALPL. In addition, treatment with lanthionine alone or in combination with calcium and phosphate reduced Inorganic Pyrophosphate Transport Regulator (ANKH) gene expression, a protective factor toward the mineralizing process. Moreover, lanthionine in a pro-calcifying condition induced the activation of ERK1/2, which is not associated with an increase in DKK1 protein levels. Our data underscored a link between mineral disease and the alterations of sulfur amino acid metabolisms at a cell and molecular level. These results set the basis for the understanding of the link between uremic toxins and mineral-bone disorder during CKD progression. Full article