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Keywords = ulcerative lymphangitis

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11 pages, 5712 KB  
Case Report
Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report
by Xiangning Huang, Renjie Deng, Haoen Huang, Huisheng Xie and Aolei Chen
Vet. Sci. 2025, 12(6), 574; https://doi.org/10.3390/vetsci12060574 - 11 Jun 2025
Viewed by 2162
Abstract
This case report detailed a rare co-infection of Pseudomonas asiatica and Enterobacter hormaechei in a 9-year-old warmblood mare, leading to severe cellulitis and secondary lymphangitis following traditional hoof blood-letting therapy. The mare exhibited acute limb swelling, fever, cutaneous ulceration, lymphatic dysfunction and unknown [...] Read more.
This case report detailed a rare co-infection of Pseudomonas asiatica and Enterobacter hormaechei in a 9-year-old warmblood mare, leading to severe cellulitis and secondary lymphangitis following traditional hoof blood-letting therapy. The mare exhibited acute limb swelling, fever, cutaneous ulceration, lymphatic dysfunction and unknown anemia. Comprehensive diagnostics, including bacterial culture, whole-genome sequencing, anti-elastin antibody (AEAb) ELISA, and diagnostic imaging, confirmed the pathogens causing cellulitis and secondary lymphangitis. AEAb levels were elevated, correlating with lymphatic degradation, while radiography and lymphangiography ruled out laminitis but identified tortuous lymphatic vessels. The treatment integrated systemic antimicrobials, anti-inflammatory therapy, combined decongestive therapy, and traditional Chinese herbal medicine, resulting in resolution of infection, improved hematological parameters, and restored athletic performance. The therapeutic regimen primarily included gentamicin, enrofloxacin, oxytetracycline, and the Wei Qi Booster. The case highlights the critical role of pathogen-directed antimicrobial selection and the potential benefits of combining conventional and holistic therapies. This report emphasizes the necessity of early, multifaceted interventions to prevent life-threatening complications in equine cellulitis–lymphangitis cases. Full article
(This article belongs to the Special Issue The Progress of Equine Medical Research in China and Beyond)
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13 pages, 285 KB  
Review
Proteomics of Toxigenic Corynebacteria
by Andreas Burkovski
Proteomes 2024, 12(1), 2; https://doi.org/10.3390/proteomes12010002 - 30 Dec 2023
Cited by 5 | Viewed by 3961
Abstract
Within the genus Corynebacterium, six species are potential carriers of the tox gene, which encodes the highly potent diphtheria exotoxin: Corynebacterium diphtheriae, Corynebacterium belfantii, Corynebacterium rouxii, Corynebacterium ulcerans, Corynebacterium pseudotuberculosis and Corynebacterium silvaticum. Based on their potential to [...] Read more.
Within the genus Corynebacterium, six species are potential carriers of the tox gene, which encodes the highly potent diphtheria exotoxin: Corynebacterium diphtheriae, Corynebacterium belfantii, Corynebacterium rouxii, Corynebacterium ulcerans, Corynebacterium pseudotuberculosis and Corynebacterium silvaticum. Based on their potential to infect different host species and cause either human infections, zoonotic diseases or infections of economically important animals, these bacteria are of high scientific and economic interest and different research groups have carried out proteome analyses. These showed that especially the combination of MS-based proteomics with bioinformatic tools helped significantly to elucidate the functional aspects of corynebacterial genomes and to handle the genome and proteome complexity. The combination of proteomic and bioinformatic approaches was also used to discover new vaccine and drug targets. In addition, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has been established as a fast and precise tool for the identification of these bacteria. Full article
16 pages, 3382 KB  
Review
The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis
by Doglas Parise, Mariana Teixeira Dornelles Parise, Anne Cybelle Pinto Gomide, Flávia Figueira Aburjaile, Rodrigo Bentes Kato, Marisol Salgado-Albarrán, Andreas Tauch, Vasco Ariston de Carvalho Azevedo and Jan Baumbach
Microorganisms 2021, 9(2), 415; https://doi.org/10.3390/microorganisms9020415 - 17 Feb 2021
Cited by 8 | Viewed by 6006
Abstract
Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, [...] Read more.
Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, goats and humans. Despite its economic and medical-veterinary importance, our understanding concerning this organism’s transcriptional regulatory mechanisms is still limited. Here, we review the state of the art knowledge on transcriptional regulatory mechanisms of this pathogenic species, covering regulatory interactions mediated by two-component systems, transcription factors and sigma factors. Key transcriptional regulatory players involved in virulence and pathogenicity of C. pseudotuberculosis, such as the PhoPR system and DtxR, are in the focus of this review, as these regulators are promising targets for future vaccine design and drug development. We conclude that more experimental studies are needed to further understand the regulatory repertoire of this important zoonotic pathogen, and that regulators are promising targets for future vaccine design and drug development. Full article
(This article belongs to the Section Systems Microbiology)
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