Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (2)

Search Parameters:
Keywords = sugar hydrazones

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
16 pages, 1444 KiB  
Article
Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues
by Ebtesam A. Basiony, Allam A. Hassan, Zahra M. Al-Amshany, Ahmed A. Abd-Rabou, Adel A.-H. Abdel-Rahman, Nasser A. Hassan and Wael A. El-Sayed
Molecules 2020, 25(2), 399; https://doi.org/10.3390/molecules25020399 - 18 Jan 2020
Cited by 24 | Viewed by 3776
Abstract
New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived sugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their per-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline [...] Read more.
New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived sugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their per-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the cyclization process. The cytotoxic activity of the synthesized compounds was studied against human breast cancer MCF7 and MDA-MB-231 cell lines as well as human colorectal cancer HCT 116 and Caco-2 cell lines. High activities were revealed by compounds 1, 8, 10, 11, and 13 against Caco-2 and MCF7 cells in addition to moderate activities exhibited by other compounds against HCT116 or MDA-MB-231 cells. Full article
Show Figures

Graphical abstract

12 pages, 205 KiB  
Article
Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1',2':4,5]- thieno[2,3-d]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation
by Aymn E. RASHAD, Ahmed H. SHAMROUKH, Randa E. ABDEL-MEGEID, Hayam H. SAYED and Nayera M. ABDEL-WAHED
Sci. Pharm. 2010, 78(1), 1-12; https://doi.org/10.3797/scipharm.0910-11 - 11 Dec 2009
Cited by 17 | Viewed by 1592
Abstract
(9-Methyl-5,6-dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)hydrazine (1) was used as a precursor for preparation of some novel 1-(9-methyl-5,6- dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)-1H-pyrazoles 27, -1H-isoindole- 1,3(2H)-dione 8, and -pyridazin-3(2H)-one 9. Moreover, the acyclic [...] Read more.
(9-Methyl-5,6-dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)hydrazine (1) was used as a precursor for preparation of some novel 1-(9-methyl-5,6- dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)-1H-pyrazoles 27, -1H-isoindole- 1,3(2H)-dione 8, and -pyridazin-3(2H)-one 9. Moreover, the acyclic C-nucleosides 10 and 11 were prepared by treating compound 1 with D-glucose. The in vitro antimicrobial activity of the tested compounds was evaluated by measuring the zone diameters and some of the prepared products showed potent antimicrobial activity in compared with those of well known drugs (standard). In general, the non-acetylated sugar hydrazone derivative 10 showed the highest antibacterial and antifungal potency among the tested compounds and standard with IZ = 22, 21 and 22 mm and MIC = 62.5 and 31.25 μg/ml, respectively. Full article
Back to TopTop