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Keywords = silanol quantity

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11 pages, 1904 KB  
Article
Research on the Particle Growth Process of Colloidal Silica Derived from the Sol-Gel Process Using Active Silicic Acid Solutions
by Kazuaki Higuchi, Yujia Liu and Masafumi Unno
Solids 2025, 6(2), 20; https://doi.org/10.3390/solids6020020 - 6 May 2025
Viewed by 1384
Abstract
The influence of the quantity of silanol in an active silicic acid solution (ASAS) on the growth rate of colloidal silica particles was investigated. The quantity of silanol in the ASAS was controlled by varying the acid concentration as a hydrolysis catalyst for [...] Read more.
The influence of the quantity of silanol in an active silicic acid solution (ASAS) on the growth rate of colloidal silica particles was investigated. The quantity of silanol in the ASAS was controlled by varying the acid concentration as a hydrolysis catalyst for tetramethoxysilane (TMOS). As expected, the particle growth rate was confirmed to be a function of the acid concentration in the water used to prepare the ASAS. In addition, when the entire process was conducted under basic conditions to obtain spherical particles, the initial basicity had a secondary influence on the particle growth rate. When a partial process was conducted under acidic conditions to obtain morphologically modified particles, the low acidity was found to have a secondary influence on the particle growth rate. Furthermore, it was clarified that the relative silica deposition rate based on acid-free ASAS could be predicted by assuming the seed particle size at the time it was determined. Thus, a production control system was established for highly purified colloidal silica using ASAS derived from TMOS. Full article
(This article belongs to the Special Issue Hybrid Sol-Gel Materials)
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19 pages, 9456 KB  
Article
Reversed-Phase Medium-Pressure Liquid Chromatography Purification of Omega-3 Fatty Acid Ethyl Esters Using AQ-C18
by Mingxin Sang, Nan Pan, Jingna Wu, Xiaoting Chen, Shuilin Cai, Huan Fang, Meitian Xiao, Xiaoming Jiang and Zhiyu Liu
Mar. Drugs 2024, 22(6), 285; https://doi.org/10.3390/md22060285 - 19 Jun 2024
Cited by 1 | Viewed by 5214
Abstract
Omega-3 fatty acids are in high demand due to their efficacy in treating hypertriglyceridemia and preventing cardiovascular diseases. However, the growth of the industry is hampered by low purity and insufficient productivity. This study aims to develop an efficient RP-MPLC purification method for [...] Read more.
Omega-3 fatty acids are in high demand due to their efficacy in treating hypertriglyceridemia and preventing cardiovascular diseases. However, the growth of the industry is hampered by low purity and insufficient productivity. This study aims to develop an efficient RP-MPLC purification method for omega-3 fatty acid ethyl esters with high purity and capacity. The results indicate that the AQ-C18 featuring polar end-capped silanol groups outperformed C18 and others in retention time and impurity separation. By injecting pure fish oil esters with a volume equivalent to a 1.25% bed volume on an AQ-C18 MPLC column using a binary isocratic methanol–water (90:10, v:v) mobile phase at 30 mL/min, optimal omega-3 fatty acid ethyl esters were obtained, with the notable purity of 90.34% and a recovery rate of 74.30%. The total content of EPA and DHA produced increased from 67.91% to 85.27%, meeting the acceptance criteria of no less than 84% set by the 2020 edition of the Pharmacopoeia of the People’s Republic of China. In contrast, RP-MPLC significantly enhanced the production efficiency per unit output compared to RP-HPLC. This study demonstrates a pioneering approach to producing omega-3 fatty acid ethyl esters with high purity and of greater quantity using AQ-C18 RP-MPLC, showing this method’s significant potential for use in industrial-scale manufacturing. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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