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Search Results (3)

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Keywords = second near-infrared biowindow

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13 pages, 2569 KB  
Article
High Performance Gold Nanorods@DNA Self-Assembled Drug-Loading System for Cancer Thermo-Chemotherapy in the Second Near-Infrared Optical Window
by Wei Chang, Junfeng Wang, Jing Zhang, Qing Ling, Yumei Li and Jie Wang
Pharmaceutics 2022, 14(5), 1110; https://doi.org/10.3390/pharmaceutics14051110 - 23 May 2022
Cited by 13 | Viewed by 3745
Abstract
In terms of synergistic cancer therapy, biological nanomaterials with a second near-infrared (NIR-II) window response can greatly increase photothermal effects and photoacoustic imaging performance. Herein, we report a novel stimuli-responsive multifunctional drug-loading system which was constructed by integrating miniature gold nanorods (GNR) as [...] Read more.
In terms of synergistic cancer therapy, biological nanomaterials with a second near-infrared (NIR-II) window response can greatly increase photothermal effects and photoacoustic imaging performance. Herein, we report a novel stimuli-responsive multifunctional drug-loading system which was constructed by integrating miniature gold nanorods (GNR) as the NIR-II photothermal nanorods and cyclic ternary aptamer (CTA) composition as a carrier for chemotherapy drugs. In this system, doxorubicin hydrochloride (DOX, a chemotherapy drug) binds to the G-C base pairs of the CTA, which exhibited a controlled release behavior based on the instability of G-C base pairs in the slightly acidic tumor microenvironment. Upon the 1064 nm (NIR-II biowindow) laser irradiation, the strong photothermal and promoted cargo release properties endow gold nanorods@CTA (GNR@CTA) nanoparticles displaying excellent synergistic anti-cancer effect. Moreover, the GNR@CTA of NIR also possesses thermal imaging and photoacoustic (PA) imaging properties due to the strong NIR region absorbance. This work enables to obtaining a stimuli-responsive “all-in-one” nanocarrier, which are promising candidate for bimodal imaging diagnosis and chemo-photothermal synergistic therapy. Full article
(This article belongs to the Special Issue Polymer and Lipid-based Materials for Nanodrug Delivery Systems)
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16 pages, 4255 KB  
Review
Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy
by Li Zhang, Helen Forgham, Ao Shen, Ruirui Qiao and Bing Guo
Biosensors 2022, 12(2), 86; https://doi.org/10.3390/bios12020086 - 31 Jan 2022
Cited by 26 | Viewed by 5654
Abstract
Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability to stop growth and metastasis or prevent relapse. Thus, synergistic strategies that combine different therapeutic modalities to improve performance have become the new research trend. In [...] Read more.
Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability to stop growth and metastasis or prevent relapse. Thus, synergistic strategies that combine different therapeutic modalities to improve performance have become the new research trend. In this regard, the integration of photothermal therapy (PTT) with chemodynamic therapy (CDT), especially PTT/CDT in the second near-infrared (NIR-II) biowindow, has been demonstrated to be a highly efficient and relatively safe concept. With the rapid development of nanotechnology, nanoparticles can be designed from specific elements, such as Fe, that are equipped with both PTT and CDT therapeutic functions. In this review, we provide an update on the recent advances in Fe-based nanoplatforms for combined PTT/CDT. The perspectives on further improvement of the curative efficiency are described, highlighting the important scientific obstacles that require resolution in order to reach greater heights of clinical success. We hope this review will inspire the interest of researchers in developing novel Fe-based nanomedicines for multifunctional theranostics. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors for Biomedical Applications)
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12 pages, 2158 KB  
Article
Superparamagnetic Nanoparticles with Efficient Near-Infrared Photothermal Effect at the Second Biological Window
by Maria Antònia Busquets, Juan Marcos Fernández-Pradas, Pedro Serra and Joan Estelrich
Molecules 2020, 25(22), 5315; https://doi.org/10.3390/molecules25225315 - 14 Nov 2020
Cited by 15 | Viewed by 3852
Abstract
Superparamagnetic nanoparticles (iron oxide nanoparticles—IONs) are suitable for hyperthermia after irradiating with radiofrequency radiation. Concerning the suitability for laser ablation, IONs present a low molar absorption coefficient in the near-infrared region close to 800 nm. For this reason, they are combined with other [...] Read more.
Superparamagnetic nanoparticles (iron oxide nanoparticles—IONs) are suitable for hyperthermia after irradiating with radiofrequency radiation. Concerning the suitability for laser ablation, IONs present a low molar absorption coefficient in the near-infrared region close to 800 nm. For this reason, they are combined with other photothermal agents into a hybrid composite. Here, we show that IONs absorb and convert into heat the infrared radiation characteristic of the so-called second-biological window (1000–1350 nm) and, in consequence, they can be used for thermal ablation in such wavelengths. To the known excellent water solubility, colloidal stability and biocompatibility exhibited by IONs, an outstanding photothermal performance must be added. For instance, a temperature increase of 36 °C was obtained after irradiating at 8.7 W cm−2 for 10 min a suspension of IONs at iron concentration of 255 mg L−1. The photothermal conversion efficiency was ~72%. Furthermore, IONs showed high thermogenic stability during the whole process of heating/cooling. To sum up, while the use of IONs in the first bio-window (700–950 nm) presents some concerns, they appear to be good photothermal agents in the second biological window. Full article
(This article belongs to the Special Issue Nanomaterials in Photothermal Therapy beyond 2020)
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