Search Results (9)

Based on panel data from 255 prefecture-level and above cities in China from 2011 to 2023, this article innovatively integrates digital rural construction, the digital literacy of farmers, green production of farmers, and land use efficiency into a unified framework for theoretical and empirical research. Our research has found that digital rural construction can indeed have a direct promoting effect on land use efficiency, with an impact coefficient of 0.451, which is significant at the 1% level. The addition of control variables and robustness tests indicates that this result is robust. Building digital villages can also boost land use efficiency in a roundabout way by enhancing farmers’ digital skills and promoting eco-friendly farming practices, with impact coefficients of 0.445 and 0.283, respectively, both significant at the 1% level. The impact of digital rural areas on land use efficiency is heterogeneous. Our studies have indicated that the impact of digital rural development on the shift towards green production among farmers cultivating cash crops is more significant compared to those growing grain crops. Additionally, the influence of digital rural development on improving land use efficiency is more pronounced among farmers who are risk-averse compared to those who are not. Full article

Cashmere goats possess two types of hair follicles, with the secondary hair follicles producing valuable cashmere fiber used for textiles. The growth of cashmere exhibits a seasonal pattern arising from photoperiod change. Transcription factors play crucial roles during this process. The transcription factor, cold-shock domain, containing C2 (Csdc2) plays a crucial role in modulating cell proliferation and differentiation. Our preceding research indicated that the expression of Csdc2 changes periodically during anagen to telogen. However, the mechanisms of Csdc2 in regulating SHF growth remain unclear. Here, we found that the knockdown of Csdc2 inhibits the proliferation of dermal papilla cells. ChIP-Seq analysis showed that Csdc2 had a unique DNA binding motif in SHFs. Through conjoint analysis of ChIP-Seq and RNA-Seq, we revealed a total of 25 candidate target genes of Csdc2. Notably, we discovered a putative Csdc2 binding site within roundabout guidance receptor 2 (Robo2) on chromosome 1 of the goat genome. Furthermore, qRT-PCR and dual-luciferase reporter assay confirmed Csdc2’s positive regulatory influence on Robo2. These findings expand the research field of hair follicle transcriptional regulatory networks, offering insights into molecular breeding strategies to enhance cashmere production in goats. Full article

The authors present the unsolved issue of the contextual design of urban intersections (UI) from the point of view of traffic noise emissions around residential buildings in the Slovak context. Noise barriers are very rarely used in urban areas, due to such reasons as lack of space for their installation, traffic safety (view at intersections), architectural factors, as well as the fact that they represent a barrier for pedestrians and cyclists. The use of low-noise asphalt pavements is limited in urban areas primarily due to the high cost of production and maintenance of these covers, their limited durability in a colder climate, and lower efficiency compared to the roads outside urban areas. From this aspect of urban intersection design, the authors focused on the identification of individual factors associated with the significant reduction (2–8 dB) of traffic noise induced by the reconstruction of non-signalized urban intersections into roundabouts. The authors draw attention to the fact that both new surfaces of intersection branches and the change in traffic processes contribute to the aforementioned reduction. This finding was obtained by comparing direct measurements of noise levels and the results of their predicted values using validated 3D models in the CadnaA program. Noise emissions were measured by a noise analyzer (NOR-1210), and traffic noise emissions were predicted by the “Nouvelle Méthode de Prévision du Bruit” methodology (NMPB-1996). Based on the analysis of the measured and predicted traffic noise levels, the authors objectivized the share of reduction in traffic processes in the 2–3 dB range. The authors objectified the share of traffic noise reduction due to the change in traffic processes as being in the 2.2–3.3 dB range. The presented research results could contribute to a quantifiable reduction in the noise load in the external environment of residential buildings using the contextual design of intersections. Full article

Roundabouts have become a common type of intersection design in many countries. The area of the center island can be used to install a photovoltaic system to power local loads such as lighting systems. The objective of this study is to evaluate the degree of self-sufficiency that a roundabout can achieve depending on the availability of the area for the installation of a photovoltaic system and the energy demand for lighting. The methodology is divided into five steps aimed at calculating the parameters required to characterize the roundabouts from the point of view of the electricity that can be generated by the photovoltaic systems installed, and then to evaluate the energy consumption required to operate the different system solutions for lighting. The mini roundabouts are not considered as a location for the photovoltaic system; in fact, the minimum diameter must be between 29 and 34 m. Considering the available irradiance in Italy, systems with monocrystalline silicon modules are sufficient to ensure energy self-sufficiency at diameters of 24 m or more. Systems with polycrystalline silicon modules are suitable to ensure energy self-sufficiency at diameters of 25/26 m or more. Photovoltaic (PV) technology continues to make progress in increasing efficiency, such as bifacial PV modules. This means that even smaller roundabouts could be eligible for a PV system sized to meet local electricity needs. Full article

From the perspective of production structure sustainability, this study investigates the source of innovation power of high-tech enterprises. It proposes that the roundaboutness of production structure is the sustainable driving force for improving innovation capability in high-tech enterprises, and enterprises can improve their innovation capability by absorbing technology from three paths. The proposed model was tested based on the survey data from 315 enterprises in 10 robotics industrial parks in the Yangtze River Delta region of China. The results show that the roundaboutness of production structure has a positive influence on the innovation capability of high-tech enterprises, which is mediated by technology absorption paths (i.e., independent development in high-tech enterprises, technology acquisition in high-tech enterprises and government policy compliance in high-tech enterprises). Meanwhile, the enterprise has different technology absorption path at different position in production structure. The findings have important enlightenment for enterprises to improve market competitiveness, production efficiency and technological innovation capability, and provides a practical basis for better ways of leveraging market and capital and more effective government processes in industrial innovation. Full article

By dividing the production process into technical processes and procedural processes, this paper supplements the theoretical connotation of production roundaboutness, and analyzes and discusses the micro impact mechanisms of environmental regulation on industrial structure through production roundaboutness. Subsequently, based on the panel data of 31 provinces and cities in China from 2003 to 2017, a panel threshold model was adopted to empirically analyze the impact of environmental regulation, the synergy of environmental regulation, and roundabout production on the transformation and upgrading of industrial structures. The result shows there is a single threshold effect of environmental regulation on the upgrading and transformation of industrial structures based on the threshold variable of production roundaboutness. As well as the continuous increase in production roundaboutness, significant positive correlations between environmental regulation and the transformation and upgrading of industrial structures gradually vanish. However, the synergistic growth of environmental regulation and production roundaboutness is significantly and negatively correlated with industrial structure transformation and upgrade. Investment in social fixed assets has a positive incentive effect on industrial structure transformation and upgrade, while government expenditure, foreign trade, and opening-up have different degrees of inhibition on it. In order to speed up the transformation and upgrading of industrial structures under environmental and resource constraints, it is necessary to straighten out the relationship between environmental regulation and roundabout production, and to promote the scientific development of both. Full article

Congenital adrenal hyperplasia (CAH) is the most common cause of primary adrenal insufficiency in children and adolescents. It comprises several clinical entities associated with mutations in genes, encoding enzymes involved in cortisol biosynthesis. The mutations lead to considerable (non-classic form) to almost complete (classic form) inhibition of enzymatic activity, reflected by different phenotypes and relevant biochemical alterations. Up to 95% cases of CAH are due to mutations in CYP21A2 gene and subsequent 21α-hydroxylase deficiency, characterized by impaired cortisol synthesis and adrenal androgen excess. In the past two decades an alternative (“backdoor”) pathway of androgens’ synthesis in which 5α-androstanediol, a precursor of the 5α-dihydrotestosterone, is produced from 17α-hydroxyprogesterone, with intermediate products 3α,5α-17OHP and androsterone, in the sequence and with roundabout of testosterone as an intermediate, was reported in some studies. This pathway is not always considered in the clinical assessment of patients with hyperandrogenism. The article describes the case of a 17-year-old female patient with menstrual disorders and androgenization (persistent acne, advanced hirsutism). Her serum dehydroepiandrosterone sulfate and testosterone were only slightly elevated, along with particularly high values for 5α-dihydrotestosterone. In 24 h urine collection, an increased excretion of 16α-OHDHEA—a dehydroepiandrosterone metabolite—and pregnanetriolone—a 17α-hydroxyprogesterone metabolite—were observed. The investigations that we undertook provided evidence that the girl suffered from non-classic 21α-hydroxylase deficiency with consequent enhancement of the androgen “backdoor” pathway in adrenals, peripheral tissues or both, using adrenal origin precursors. The paper presents diagnostic dilemmas and strategies to differentiate between various reasons for female hyperandrogenism, especially in childhood and adolescence. Full article

An adequately functionally located traffic infrastructure is an important factor in the mobility of people because it affects the quality of traffic, safety and efficiency of carrying out transportation activities. Locating a roundabout on an urban network is an imperative for road engineering to address traffic problems such as reduction of traffic congestion, enhancement of security and sustainability, etc. Therefore, this paper evaluates potential locations for roundabout construction using Rough BWM (Best Worst Method) and Rough WASPAS (Weighted Aggregated Sum Product Assessment) models. Determination of relative criterion weights on the basis of which the potential locations were evaluated was carried out using the Rough BWM method. In this paper, in order to enable the most precise consensus for group decision-making, a Rough Hamy aggregator has been developed. The main advantage of the Hamy mean (HM) operator is that it can capture the interrelationships among multi-input arguments and can provide DMs more options. Until now, there is no research based on HM operator for aggregating imprecise and uncertain information. The obtained indicators are described through eight alternatives. The results show that the fifth and sixth alternatives are the locations that should have a priority in the construction of roundabouts from the perspective of sustainable development, which is confirmed throughout changes of parameter k and with comparing to other methods in the sensitivity analysis. Full article

An orbital energy-based reaction analysis theory is presented as an extension of the orbital-based conceptual density functional theory. In the orbital energy-based theory, the orbitals contributing to reactions are interpreted to be valence orbitals giving the largest orbital energy variation from reactants to products. Reactions are taken to be electron transfer-driven when they provide small variations for the gaps between the contributing occupied and unoccupied orbital energies on the intrinsic reaction coordinates in the initial processes. The orbital energy-based theory is then applied to the calculations of several ${\mathrm{S}}_{\mathrm{N}}$2 reactions. Using a reaction path search method, the Cl⁻ + CH₃I → ClCH₃ + I⁻ reaction, for which another reaction path called “roundabout path” is proposed, is found to have a precursor process similar to the roundabout path just before this S_N2 reaction process. The orbital energy-based theory indicates that this precursor process is obviously driven by structural change, while the successor S_N2 reaction proceeds through electron transfer between the contributing orbitals. Comparing the calculated results of the S_N2 reactions in gas phase and in aqueous solution shows that the contributing orbitals significantly depend on solvent effects and these orbitals can be correctly determined by this theory. Full article