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Keywords = radiation preparedness

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14 pages, 208 KiB  
Article
Factors Associated with Public Health Nurses’ Anxiety About Accepting Evacuees During Nuclear Disasters: A Cross-Sectional Study in Oita Prefecture, Japan
by Hiro Tsuchiya, Takumi Yamaguchi and Yuko Matsunari
Healthcare 2025, 13(1), 45; https://doi.org/10.3390/healthcare13010045 - 30 Dec 2024
Viewed by 767
Abstract
Background/Objectives: The Fukushima Daiichi Nuclear Power Station accident underscored the critical role of public health nurses (PHNs) in managing evacuees during nuclear emergencies. Despite their importance, PHNs often lack sufficient knowledge and experience, which may make them anxious about this role. This study [...] Read more.
Background/Objectives: The Fukushima Daiichi Nuclear Power Station accident underscored the critical role of public health nurses (PHNs) in managing evacuees during nuclear emergencies. Despite their importance, PHNs often lack sufficient knowledge and experience, which may make them anxious about this role. This study aimed to investigate the factors associated with PHNs’ anxiety about accepting evacuees and identify strategies to alleviate this anxiety. Methods: A cross-sectional survey was conducted among 100 PHNs working in Oita Prefecture, Japan, a region designated to receive evacuees in the event of a nuclear disaster. Data were collected via an online questionnaire assessing radiation knowledge, workplace characteristics, and anxiety about accepting evacuees. Univariate and multivariate logistic regression analyses were performed to identify the predictors of anxiety. Results: PHNs working in prefectural offices were 3.4 times more likely to feel anxious about accepting evacuees than those in municipal offices (OR = 3.488, 95% CI = 1.236–10.963, p = 0.023). Awareness of evacuation site responsibilities significantly reduced anxiety (OR = 0.412, 95% CI = 0.134–1.211, p = 0.110). Overall, knowledge of radiation was low, with only 8% correctly identifying the differences between stochastic and deterministic effects. Online training was the preferred format for education. Conclusions: Workplace characteristics and knowledge of evacuation responsibilities significantly influence PHNs’ anxiety levels. Addressing knowledge gaps through tailored, accessible training programs, particularly in online formats, is essential. Strengthening preparedness among PHNs could enhance their confidence and ability to manage evacuees effectively during nuclear disasters. Full article
9 pages, 786 KiB  
Article
Public Health Nurses’ Perceptions of Their Roles and Activities Throughout the Phases of the Fukushima Nuclear Disaster: A Qualitative Study
by Tamami Koyama, Takumi Yamaguchi and Yuko Matsunari
Nurs. Rep. 2024, 14(4), 3515-3523; https://doi.org/10.3390/nursrep14040256 - 15 Nov 2024
Cited by 1 | Viewed by 1049
Abstract
Background/Objectives: To explore how Public Health Nurses (PHNs) in Fukushima perceived their roles and activities as necessary or inadequate from the immediate aftermath through the long-term recovery of the nuclear disaster. Methods: We conducted a qualitative study using a self-administered questionnaire [...] Read more.
Background/Objectives: To explore how Public Health Nurses (PHNs) in Fukushima perceived their roles and activities as necessary or inadequate from the immediate aftermath through the long-term recovery of the nuclear disaster. Methods: We conducted a qualitative study using a self-administered questionnaire with open-ended questions to capture the perceptions of PHNs across three disaster phases: peacetime; nuclear emergency; and recovery. Responses were analyzed through qualitative content analysis. Results: PHNs’ needs and perceived inadequacies varied across the disaster phases. In peacetime, the emphasis was on education for disaster preparedness for both nurses and residents. During the nuclear emergency, the focus shifted to the need for PHN deployment and radiation screening systems, highlighting a significant gap in radiation knowledge. In the recovery phase, the importance of ongoing resident support, rumor management, and trust-building was emphasized, alongside an increased need for radiation education. Conclusions: This study highlights the critical need for phase-specific support systems and educational programs to enhance PHNs’ disaster response capabilities. It underscores the importance of preparedness plans and continuous training to improve PHNs’ effectiveness in addressing public health challenges during nuclear disasters. This study was not registered. Full article
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25 pages, 27480 KiB  
Article
A Bayesian Approach for Forecasting the Probability of Large Earthquakes Using Thermal Anomalies from Satellite Observations
by Zhonghu Jiao and Xinjian Shan
Remote Sens. 2024, 16(9), 1542; https://doi.org/10.3390/rs16091542 - 26 Apr 2024
Cited by 7 | Viewed by 1979
Abstract
Studies have demonstrated the potential of satellite thermal infrared observations to detect anomalous signals preceding large earthquakes. However, the lack of well-defined precursory characteristics and inherent complexity and stochasticity of the seismicity continue to impede robust earthquake forecasts. This study investigates the potential [...] Read more.
Studies have demonstrated the potential of satellite thermal infrared observations to detect anomalous signals preceding large earthquakes. However, the lack of well-defined precursory characteristics and inherent complexity and stochasticity of the seismicity continue to impede robust earthquake forecasts. This study investigates the potential of pre-seismic thermal anomalies, derived from five satellite-based geophysical parameters, i.e., skin temperature, air temperature, total integrated column water vapor burden, outgoing longwave radiation (OLR), and clear-sky OLR, as valuable indicators for global earthquake forecasts. We employed a spatially self-adaptive multiparametric anomaly identification scheme to refine these anomalies, and then estimated the posterior probability of an earthquake occurrence given observed anomalies within a Bayesian framework. Our findings reveal a promising link between thermal signatures and global seismicity, with elevated forecast probabilities exceeding 0.1 and significant probability gains in some strong earthquake-prone regions. A time series analysis indicates probability stabilization after approximately six years. While no single parameter consistently dominates, each contributes precursory information, suggesting a promising avenue for a multi-parametric approach. Furthermore, novel anomaly indices incorporating probabilistic information significantly reduce false alarms and improve anomaly recognition. Despite remaining challenges in developing dynamic short-term probabilities, rigorously testing detection algorithms, and improving ensemble forecast strategies, this study provides compelling evidence for the potential of thermal anomalies to play a key role in global earthquake forecasts. The ability to reliably estimate earthquake forecast probabilities, given the ever-present threat of destructive earthquakes, holds considerable societal and ecological importance for mitigating earthquake risk and improving preparedness strategies. Full article
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20 pages, 8238 KiB  
Article
The Public Health Crisis Conceptual Model: Historical Application to the World’s First Nuclear Bomb Test
by Mary Pat Couig, Roberta Lavin, Heidi Honegger Rogers and Sara Bandish Nugent
Soc. Sci. 2024, 13(4), 186; https://doi.org/10.3390/socsci13040186 - 25 Mar 2024
Viewed by 2910
Abstract
Background/purpose: The Public Health Crisis Conceptual Model was developed to identify and address healthcare and human services needs related to a disaster. The purpose of this study was to historically apply this model to the counties and populations most affected by the first [...] Read more.
Background/purpose: The Public Health Crisis Conceptual Model was developed to identify and address healthcare and human services needs related to a disaster. The purpose of this study was to historically apply this model to the counties and populations most affected by the first nuclear test in 1945, with a focus on community and local priorities, and to further describe this model and validate its usefulness. If the model had been applied in 1945, what might have been different with respect to research, epidemiological studies, and reparations? Methods: A historical, descriptive case study approach was used, with a focus on community and local priorities. Results: While it was deemed necessary to maintain secrecy surrounding the Trinity test during wartime efforts, scientists and the military knew of the potential dangers of radioactive fallout. However, they neglected to inform exposed New Mexicans after the information about the nature of the bombings of Hiroshima and Nagasaki had been made public. Conclusions: Research and epidemiological studies could have been implemented years before they were. Resources were not and have not been distributed equitably to those exposed to fallout from the Trinity test site. Using the Public Health Crisis Conceptual Model will help ensure that community and local priorities are an integral component of future disaster-related research. Full article
(This article belongs to the Special Issue Anthropological Reflections on Crisis and Disaster)
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12 pages, 1355 KiB  
Review
Management of Casualties from Radiation Events
by Robert Alan Dent
Eur. Burn J. 2023, 4(4), 584-595; https://doi.org/10.3390/ebj4040039 - 14 Nov 2023
Cited by 4 | Viewed by 2558
Abstract
Radiation events such as nuclear war, nuclear reactor incidents, and the deployment of a radioactive dispersal device (dirty bomb) are all significant threats in today’s world. Each of these events would bring significant challenges to clinicians caring for patients with burns and traumatic [...] Read more.
Radiation events such as nuclear war, nuclear reactor incidents, and the deployment of a radioactive dispersal device (dirty bomb) are all significant threats in today’s world. Each of these events would bring significant challenges to clinicians caring for patients with burns and traumatic injuries who are also contaminated or irradiated. The result of a nuclear exchange in a densely populated area could result in thousands of patients presenting with trauma, burns, and combined injury (trauma and burn in an irradiated patient). In this review, we will discuss the three major types of ionizing radiation: alpha, beta, and gamma, and their respective health hazards and biological effects. Additionally, we will discuss the types of burn injuries in a nuclear disaster, caring for the contaminated patient, and managing the combined injury of burn trauma with acute radiation syndrome. The reader will also be left with an understanding of how to prioritize lifesaving interventions, estimate the absorbed dose of radiation, and predict the onset of acute radiation syndrome. While some animal models for morbidity and mortality exist, there is limited modern day human data for patients with combined injury and burns associated with a nuclear disaster due to the infrequent nature of these events. It is extremely important to continue multidisciplinary research on the prevention of, preparedness for, and the response to nuclear events. Furthermore, continued exploration of novel treatments for radiation induced burns and the management of combined injury is necessary. Full article
(This article belongs to the Special Issue Burn Injuries Associated with Wars and Disasters)
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11 pages, 891 KiB  
Article
How Do Disaster Relief Nurses in Japan Perceive and Respond to Risks? A Cross-Sectional Study
by Aki Nishikawa, Takumi Yamaguchi, Yumiko Yamada, Hideko Urata, Tetsuko Shinkawa and Yuko Matsunari
Nurs. Rep. 2023, 13(4), 1410-1420; https://doi.org/10.3390/nursrep13040118 - 7 Oct 2023
Cited by 2 | Viewed by 2202
Abstract
This study assessed the risk perceptions among disaster relief nurses (DRNs) in Japan by focusing on 15 risk factors associated with frequent natural disasters and the ongoing coronavirus disease 2019 (COVID-19) pandemic. We conducted a cross-sectional study that targeted DRNs across six prefectures [...] Read more.
This study assessed the risk perceptions among disaster relief nurses (DRNs) in Japan by focusing on 15 risk factors associated with frequent natural disasters and the ongoing coronavirus disease 2019 (COVID-19) pandemic. We conducted a cross-sectional study that targeted DRNs across six prefectures in Japan and explored nurses’ perceptions of risks including radiation exposure, volcanic eruptions, and mass infections. The findings indicated a heightened perception of radiation and nuclear-related risks. In the context of the COVID-19 pandemic, DRNs perceived “mass infection” as a significant risk. An age-based analysis revealed that younger nurses had more dread about “mass infection” and had heightened uncertainty about the “X-ray test” compared with their older peers. Understanding DRNs’ risk perceptions is crucial for effective disaster response preparedness and training. The study highlights the need to address these perceptions to ensure that DRNs are well prepared and supported in their roles. This study was not pre-registered on a publicly accessible registry. Full article
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12 pages, 29817 KiB  
Article
A Study on Radiological Hazard Assessment for Jordan Research and Training Reactor
by Mohammad Talafha, Sora Kim and Kyung-Suk Suh
Atmosphere 2023, 14(5), 859; https://doi.org/10.3390/atmos14050859 - 11 May 2023
Cited by 2 | Viewed by 2308
Abstract
Numerical simulations of atmospheric dispersion and dose assessment were performed for the Jordan Research and Training Reactor (JRTR) to evaluate its radiological effects on surrounding population and the environment. A three-dimensional atmospheric dispersion model was applied to investigate the behavior of the radionuclides [...] Read more.
Numerical simulations of atmospheric dispersion and dose assessment were performed for the Jordan Research and Training Reactor (JRTR) to evaluate its radiological effects on surrounding population and the environment. A three-dimensional atmospheric dispersion model was applied to investigate the behavior of the radionuclides released into the air, and a dose assessment model was used to estimate the radiological impact on the population residing in nearby cities around the JRTR. Considering full core meltdown an accidental scenario, most of the source term was assumed to be released from the JRTR. Simulations were performed to calculate the air and deposition concentrations of radioactive materials for July 2013 and January 2014. The monthly averaged values of concentrations, depositions, and dose rates were analyzed to identify the most harmful effects in each month. The results showed that relatively harmful effects occurred in January 2014, and the total annual dose rate was estimated to be approximately 1 mSv outside the 10 km radius from JRTR. However, the impact of a nuclear accident is not as severe as it might seem, as the affected area is not highly populated, and appropriate protective measures can significantly reduce the radiation exposure. This study provides useful information for emergency preparedness and response planning to mitigate the radiological consequences of a nuclear accident at the JRTR. Full article
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10 pages, 2500 KiB  
Article
Application of a Portable Colorimeter for Reading a Radiochromic Film for On-Site Dosimetry
by Hiroshi Yasuda and Hikaru Yoshida
Appl. Sci. 2023, 13(8), 4761; https://doi.org/10.3390/app13084761 - 10 Apr 2023
Cited by 9 | Viewed by 2773
Abstract
Radiochromic films have widely been used for quality assurance (QA) in radiation therapy and have many advantageous features such as self-developing visible coloration, wide dose range and easiness to handle. These features have a good potential for application to other fields associated with [...] Read more.
Radiochromic films have widely been used for quality assurance (QA) in radiation therapy and have many advantageous features such as self-developing visible coloration, wide dose range and easiness to handle. These features have a good potential for application to other fields associated with high-dose radiation exposure, e.g., verification of various radiation sources used in industry and research, occupational radiation monitoring as a preparedness for radiological emergencies. One of the issues in such applications is the elaborate process of acquisition and analyses of the color image using a flatbed scanner and image processing software, which is desirably to be improved for achieving a practical on-site dosimetry. In the present study, a simple method for reading a radiochromic film by using a portable colorimeter (nix pro 2; abbreviated here “Nix”) was proposed and its feasibility for diagnostic X-rays was tested with a commercial radiochromic film (Gafchromic EBT-XD). It was found that the color intensities of red and green components of EBT-XD were successfully measured by Nix over a wide dose range up to 40 Gy. Though some angle dependence was observed, this error could be well averted by careful attention to the film direction in a reading process. According to these findings, it is expected that the proposed on-site dosimetry method of combining a radiochromic film and a portable colorimeter will be practically utilized in various occasions. Full article
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14 pages, 675 KiB  
Article
Public Health Decision Making in the Case of the Use of a Nuclear Weapon
by Magdalena Długosz-Lisiecka
Int. J. Environ. Res. Public Health 2022, 19(19), 12766; https://doi.org/10.3390/ijerph191912766 - 6 Oct 2022
Cited by 4 | Viewed by 2327
Abstract
The current geopolitical situation and the war on Ukraine’s territory generate questions about the possible use of a nuclear weapon and create the need to refresh emergency protective plans for the population. Ensuring the protection of public health is a national responsibility, but [...] Read more.
The current geopolitical situation and the war on Ukraine’s territory generate questions about the possible use of a nuclear weapon and create the need to refresh emergency protective plans for the population. Ensuring the protection of public health is a national responsibility, but the problem is of international size and global scale. Radiological or nuclear disasters need suitable decision making at the right time, which determine large effective radiation protection activities to ensure public health is protected, reduce fatalities, radiation disease, and other effects. In this study, a simulation of a single nuclear weapon detonation with an explosion yield of 0.3 and 1 Mt was applied for a hypothetical location, to indicate the required decision making and the need to trigger protocols for the protection of the population. The simulated explosion was located in a city center, in a European country, for the estimation of the size of the effects of the explosion and its consequences for public health. Based on the simulation results and knowledge obtained from historical nuclear events, practical suggestions, discussion, a review of the recommendations was conducted, exacerbated by the time constraints of a public health emergency. Making science-based decisions should encompass clear procedures with specific activities triggered immediately based on confirmed information, acquired from active or/and passive warning systems and radiometric specific analysis provided by authorized laboratories. This study has the potential to support the preparedness of decision makers in the event of a disaster or crisis-related emergency for population health management and summarizes the strengths and weaknesses of the current ability to respond. Full article
(This article belongs to the Section Global Health)
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17 pages, 1290 KiB  
Article
Citizens’ Communication Needs and Attitudes to Risk in a Nuclear Accident Scenario: A Mixed Methods Study
by Joel Rasmussen, Mats Eriksson and Johan Martinsson
Int. J. Environ. Res. Public Health 2022, 19(13), 7709; https://doi.org/10.3390/ijerph19137709 - 23 Jun 2022
Cited by 6 | Viewed by 2636
Abstract
The potential devastation that a nuclear accident can cause to public health and the surrounding environment demands robust emergency preparedness. This includes gaining a greater knowledge of citizens’ needs in situations involving radiation risk. The present study examines citizens’ attitudes to a remediation [...] Read more.
The potential devastation that a nuclear accident can cause to public health and the surrounding environment demands robust emergency preparedness. This includes gaining a greater knowledge of citizens’ needs in situations involving radiation risk. The present study examines citizens’ attitudes to a remediation scenario and their information and communication needs, using focus group data (n = 39) and survey data (n = 2291) from Sweden. The focus groups uniquely showed that adults of all ages express health concerns regarding young children, and many also do so regarding domestic animals. Said protective sentiments stem from a worry that even low-dose radiation is a transboundary, lingering health risk. It leads to doubts about living in a decontaminated area, and high demands on fast, continuous communication that in key phases of decontamination affords dialogue. Additionally, the survey results show that less favorable attitudes to the remediation scenario—worry over risk, doubt about decontamination effectiveness, and preferences to move away from a remediation area—are associated with the need for in-person meetings and dialogue. Risk managers should thus prepare for the need for both in-person meetings and frequent information provision tasks, but also that in-person, citizen meetings are likely to feature an over-representation of critical voices, forming very challenging communication tasks. Full article
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9 pages, 1408 KiB  
Commentary
The Current Safety Regulation for Radiation Emergency Medicine in Korea
by You Yeon Choi, Seung Yeol Yoo, Mihyun Yang and Ki Moon Seong
Int. J. Environ. Res. Public Health 2021, 18(23), 12434; https://doi.org/10.3390/ijerph182312434 - 26 Nov 2021
Viewed by 2202
Abstract
Radiation emergency medicine (REM) systems are operated around the world to provide specialized care for injured individuals who require immediate medical attention in accidents. This manuscript describes the current status of REM safety regulation in Korea and summarizes an assessment of the effects [...] Read more.
Radiation emergency medicine (REM) systems are operated around the world to provide specialized care for injured individuals who require immediate medical attention in accidents. This manuscript describes the current status of REM safety regulation in Korea and summarizes an assessment of the effects of this regulation. Responding to the requests of people for stronger safety regulations related to radiation exposure, a unique REM safety regulation for nuclear licensees, which is enforceable by laws, has been established and implemented. It is not found in other countries. It can provide a good example in practice for sustainable REM management including document reviews on medical response procedures and inspections of equipment and facilities. REM preparedness of nuclear or radiologic facilities has been improved with systematic implementation of processes contained in the regulation. In particular, the medical care system of licensees has become firmly coordinated in the REM network at the national level, which has enhanced their abilities by providing adequate medical personnel and facilities. This legal regulation service has contributed to preparing the actual medical emergency response for unexpected accidents and should ultimately secure the occupational safety for workers in radiation facilities. Full article
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11 pages, 660 KiB  
Article
Assessment of an Emergency Medicine System for Radiation Accidents in Korea: A State Survey of the Workers Involved the Medical Response to Radiation Accidents
by You Yeon Choi, Mihyun Yang, Younghyun Lee, Eunil Lee, Young Woo Jin and Ki Moon Seong
Int. J. Environ. Res. Public Health 2021, 18(5), 2458; https://doi.org/10.3390/ijerph18052458 - 2 Mar 2021
Cited by 1 | Viewed by 2201
Abstract
Radiation emergency medicine systems are operated around the world to provide special care for the injured that require immediate medical attention in accidents. The objective of this survey was to evaluate people’s perception of those who design the emergency medical plan for radiation [...] Read more.
Radiation emergency medicine systems are operated around the world to provide special care for the injured that require immediate medical attention in accidents. The objective of this survey was to evaluate people’s perception of those who design the emergency medical plan for radiation accidents and those who supervise it in Korea. A questionnaire survey was conducted on the people involved in a regulatory system for medical response in a radiation emergency. Of 150 survey recipients, 133 (88.7%) completed the survey, including 92 workers and 41 inspectors. The respondents expressed the view that the national emergency medical plan is prepared above the average level using a Likert-style scale of 1 to 5 (mean = 3.55, SD = 0.74). Interestingly, using the Mann–Whitney U test, it could be shown that inspectors evaluated the emergency medical system for radiation accidents more strictly in all of the questions than the licensee workers, especially on radiation medical emergency preparedness (p = 0.004) and the governmental regulatory policy for radiation safety (p = 0.007). For a more efficient system of radiation emergency medicine, licensee workers prioritized the workforce, whereas inspectors favored laws and regulations for safety. The survey results show different perspectives between inspectors and licensee workers, which stem from the actual properties of each occupational role in the regulatory system for radiation medical emergency. These data could be utilized for communication and interaction with relevant people to improve the medical response preparedness against radiation accidents. Full article
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16 pages, 27007 KiB  
Article
The ESTE Decision Support System for Nuclear and Radiological Emergencies: Atmospheric Dispersion Models
by Ľudovít Lipták, Eva Fojcíková, Monika Krpelanová, Viera Fabová and Peter Čarný
Atmosphere 2021, 12(2), 204; https://doi.org/10.3390/atmos12020204 - 3 Feb 2021
Cited by 3 | Viewed by 3249
Abstract
The ESTE system is running in nuclear crisis centers at various levels of emergency preparedness and response in Slovakia, the Czech Republic, Austria, Bulgaria, and Iran (at the Bushehr Nuclear Power Plant, monitored by the International Atomic Energy Agency (IAEA)). ESTE is a [...] Read more.
The ESTE system is running in nuclear crisis centers at various levels of emergency preparedness and response in Slovakia, the Czech Republic, Austria, Bulgaria, and Iran (at the Bushehr Nuclear Power Plant, monitored by the International Atomic Energy Agency (IAEA)). ESTE is a decision-support system that runs 24/7 and serves the crisis staff to propose actions to protect inhabitants against radiation in case of a nuclear accident. ESTE is also applicable as a decision-support system in case of a malicious act with a radioactive dispersal device in an urban or industrial environment. The dispersion models implemented in ESTE are the Lagrangian particle model (LPM) and the Puff trajectory model (PTM). We describe model approaches as implemented in ESTE. The PTM is applied in ESTE for the dispersion calculation near the point of release, up to 100 km from the point of a nuclear accident. The LPM for general atmospheric transport is applied for short-range, meso-scale and large-scale dispersion, up to dispersion on the global scale. Additionally, a specific micro-scale implementation of the LPM is applied for urban scale dispersion modeling. The dispersion models of ESTE are joined with radiological-consequences models to calculate a complete spectrum of radiological parameters—effective doses, committed doses, and dose rates by various irradiation pathways and by various radionuclides. Finally, radiation protective measures, like sheltering, iodine prophylaxis, or evacuation, evaluated on the base of predicted radiological impacts, are proposed. The dispersion and radiological models of the state-of-the-art ESTE systems are described. The results of specific analyses, like the number of particles applied, the initial spatial distribution of the source, and the height of the bottom reference layer, are presented and discussed. Full article
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12 pages, 1542 KiB  
Article
An Attempt to Reduce the Background Free Radicals in Fingernails for Monitoring Accidental Hand Exposure of Medical Workers
by Chryzel Angelica B. Gonzales, Jolan E. Taño and Hiroshi Yasuda
Appl. Sci. 2020, 10(24), 8949; https://doi.org/10.3390/app10248949 - 15 Dec 2020
Cited by 8 | Viewed by 2316
Abstract
While it is recognized that some medical workers could receive significantly higher radiation doses to their hands than the routinely monitored personal doses, accurate retrospective dosimetry of their hand exposure is still challenging. To solve this issue, a combination of electron spin resonance [...] Read more.
While it is recognized that some medical workers could receive significantly higher radiation doses to their hands than the routinely monitored personal doses, accurate retrospective dosimetry of their hand exposure is still challenging. To solve this issue, a combination of electron spin resonance (ESR) measurement and fingernails is worth to be investigated. However, the application of fingernail ESR dosimetry requires establishing an effective protocol to eliminate the background signal (BKG) which changes due to mechanical stress and other unclear factors, so that the radiation doses would be precisely evaluated from the radiation-induced signals (RIS) only. Thus, the authors investigated possible applications of antioxidants to remove or reduce the BKG in fingernails. In the present study, the effectiveness of chemical treatment using the dithiothreitol (DTT) reducing reagent was examined in irradiated and unirradiated fingernails. Chemically and non-chemically treated fingernails were subsequently exposed to 20 Gy of 137Cs γ-rays and the time changes of the BKG and RIS were confirmed in two different storage conditions: vacuum chamber and freezer. The results show that the non-chemically treated fingernails displayed significant intra-individual variations in the peak-to-peak intensities of both BKG and RIS. RIS from chemically and non-chemically treated samples showed correlations after freezer storage; signals were more stable than the samples stored in the vacuum chamber. Moreover, while the BKG of non-chemically treated samples demonstrated higher levels than those chemically treated, the intra-individual variations were further reduced by the DTT treatment. Our results imply that the use of an antioxidant for hand washing of medical workers prior to starting their work could be effective in reducing the pre-existing free radicals in their fingernails. This also suggests a practical application of hand exposure monitoring using fingernails as a part of radiological emergency preparedness in occupations where radiation or radionuclides are used. Research for finding safer and easier-to-handle antioxidants is to be focused on in future studies. Full article
(This article belongs to the Special Issue Applications of Medical Physics)
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14 pages, 2812 KiB  
Article
Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
by Meetha Medhora, Tracy Gasperetti, Ashley Schamerhorn, Feng Gao, Jayashree Narayanan, Zelmira Lazarova, Elizabeth R. Jacobs, Sergey Tarima and Brian L. Fish
Int. J. Mol. Sci. 2020, 21(11), 3908; https://doi.org/10.3390/ijms21113908 - 30 May 2020
Cited by 11 | Viewed by 2709
Abstract
The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE), for preparedness against a radiological attack or accident. Combined injuries from concomitant trauma and radiation are [...] Read more.
The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE), for preparedness against a radiological attack or accident. Combined injuries from concomitant trauma and radiation are likely in these scenarios. Either exacerbation or mitigation of radiation damage by wound trauma has been previously reported in preclinical studies. Female WAG/RijCmcr rats received 13 Gy X-rays, with partial-body shielding of one leg. Within 2 h, irradiated rats and non-irradiated controls were given full-thickness skin wounds with or without lisinopril, started orally 7 days after irradiation. Morbidity, skin wound area, breathing interval and blood urea nitrogen were measured up to 160 days post-irradiation to independently evaluate wound trauma and DEARE. Wounding exacerbated morbidity in irradiated rats between 5 and 14 days post-irradiation (during the ARS phase), and irradiation delayed wound healing. Wounding did not alter delayed morbidities from radiation pneumonitis or nephropathy after 30 days post-irradiation. Lisinopril did not mitigate wound healing, but markedly decreased morbidity during DEARE from 31 through 160 days. The results derived from this unique model of combined injuries suggest different molecular mechanisms of injury and healing of ARS and DEARE after radiation exposure. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Combined Radiation Injury and Its Therapies)
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