Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = pyrazolylnucleosides

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
16 pages, 1067 KB  
Article
Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides
by Yogesh Yadav, Deepti Sharma, Kumar Kaushik, Vineet Kumar, Amitabh Jha, Ashok K. Prasad, Christophe Len, Sanjay V. Malhotra, Jesper Wengel and Virinder S. Parmar
Molecules 2019, 24(21), 3922; https://doi.org/10.3390/molecules24213922 - 30 Oct 2019
Cited by 7 | Viewed by 4379
Abstract
The synthesis of novel pyrazolylnucleosides 3ae, 4ae, 5ae, and 6ae are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5ae and 6a [...] Read more.
The synthesis of novel pyrazolylnucleosides 3ae, 4ae, 5ae, and 6ae are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5ae and 6ae were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI50 9.3 µM) and breast cancer cell line HS 578T (GI50 3.0 µM). Full article
Show Figures

Graphical abstract

Back to TopTop