Search Results (91)

This study investigates cement–bentonite slurries with hydration accelerators for borehole backfilling applications in infrastructure reconstruction projects. Two formulations with different accelerator dosages (5 and 10 kg/m³) were evaluated through combined experimental testing and Moving Particle Semi-implicit (MPS) numerical modeling to optimize material performance. The research focuses on time-dependent rheological evolution and its impact on construction performance, particularly bleeding resistance and workability retention. Experimental flow tests revealed that both formulations maintained similar initial flowability (240–245 mm spread diameter), but the higher accelerator dosage resulted in 33% flow reduction after 60 min compared to 12% for the lower dosage. Bleeding tests demonstrated significant improvement in phase stability, with bleeding rates reduced from 2.5% to 1.5% when accelerator content was doubled. The MPS framework successfully reproduced experimental behavior with prediction accuracies within 3%, enabling quantitative analysis of time-dependent rheological parameters through inverse analysis. The study revealed that yield stress evolution governs both flow characteristics and bleeding resistance, with increases several hundred percent over 60 min while plastic viscosity remained relatively constant. Critically, simulations incorporating time-dependent viscosity changes accurately predicted bleeding behavior, while constant-viscosity models overestimated bleeding rates by 60–130%. The higher accelerator formulation (10 kg/m³) provided an optimal balance between initial workability and long-term stability for typical borehole backfilling operations. This integrated experimental–numerical approach provides practical insights for material optimization in infrastructure reconstruction projects, particularly relevant for aging infrastructure requiring proper foundation treatment. The methodology offers construction practitioners a robust framework for material selection and performance prediction in borehole backfilling applications, contributing to improved construction quality and reduced project risks. Full article

Chlorine decay in water distribution networks is significantly affected by the presence of private storage tanks, particularly due to the orifice size and retention time, which influence both hydraulic flow behavior and water residence time. This study introduces a novel simulation framework that integrates pressure-driven analysis with a first-order kinetic model for chlorine decay, implemented using the WQnetXL tool and validated through simulations in EPANET. Two schematic models, including a real-world case from Dubai, were analyzed under varying orifice sizes and retention times. Results show that larger orifices lead to higher initial chlorine concentrations during tank filling due to increased flow rates, but result in a rapid decline in chlorine levels once the tanks reach full capacity. In contrast, smaller orifices maintain more stable chlorine concentrations over time due to prolonged inflow durations. Extended retention times further delay tank filling and sustain higher chlorine levels until the system transitions to behavior typical of demand-driven analysis. A reliability assessment of the Dubai case study indicated that incorporating private tanks can result in deviations in chlorine concentration of up to 30 percent compared to conventional models. This approach addresses a key gap in conventional network modeling by quantifying the influence of decentralized storage on disinfection effectiveness and network reliability. Full article

Background: The processing of harvested fat for transplantation is critical to fat graft performance. In breast reconstruction, larger volumes of fat are being grafted and, in some clinical cases, are being implanted within radiated tissue. This preclinical animal study evaluated the effects of radiation on retention volume and fat graft quality after processing by decantation or REVOLVE™ technology (Allergan Aesthetics, an AbbVie Company), a filtration-based device that can process lipoaspirates and remove unwanted contaminants prior to grafting. Methods: Lipoaspirate was collected from human donors (n = 6), processed using either REVOLVE™ technology or decantation, and implanted (0.5 cc) into 60 athymic mice for 4 weeks with or without a single 35-Gy radiation dose 12 weeks prior. Volume composition, MRI, and weight-based volumetric assessment of grafted fat were performed and compared between radiated and non-radiated mice. Results: Volume composition analysis demonstrated significantly higher fat content and lower aqueous fluid with REVOLVE™ technology than with decantation, with minimal cellular debris and free oil. MRI-based and weight-based volume analysis demonstrated a significantly higher percent retention with REVOLVE™ technology than decantation in nonirradiated and irradiated sites, respectively. Pathology scoring showed a significant decrease in fibrosis within grafts processed with REVOLVE™ technology in nonirradiated sites. Conclusions: Results suggest that fat processed using REVOLVE™ technology provides better early volume retention and quality of fat grafts compared to decantation, both in healthy and radiation-treated surgical sites. Full article

Objective: This study aimed to identify components of a trauma-informed, culturally sensitive eating-disorder-specific nutrition-focused physical examination (ED-NFPE) tool. Method: The modified Delphi methodology was used to develop a consensus on the clinical relevance of nine evidence-informed ED-specific nutrition examination domains and 46 components within those domains. Purposive sampling was used to recruit a panel of registered dietitian nutritionist (RDN) experts in the ED field. The panelists responded to survey statements on a five-point Likert scale. The panelists also provided qualitative feedback on domain and component additions, exclusions, modifications, and trauma-informed culturally sensitive examination practice techniques. Results: Twenty-two RDN expert panelists completed Round One of the study, and eighteen panelists completed Round Two (82% retention). Twenty-one were female. Fifteen panelists had ten or more years of experience in ED dietetics. Fifty percent held an advanced practice credential from the International Association of Eating Disorders Professionals (IAEDP). After the two survey rounds, the nine ED-NFPE domains and 46 of the 48 components achieved a consensus for clinical relevance. The panelists proposed two new examination components and provided qualitative feedback for trauma-informed culturally sensitive practice techniques in all nine domains. Conclusions: This modified Delphi study design was chosen to reach a consensus on developing an ED-NFPE tool, as there are few current evidence-based guidelines for nutrition examinations in ED care. An NFPE tool specifically designed to detect the nutrition-related findings of individuals with EDs would strengthen the overall nutrition assessment. RDNs at every level of care and with all degrees of experience could use an ED-NFPE to inform patient treatment goals. Full article

Background: Alopecia areata is an autoimmune disorder that causes hair loss in clumps about the size and shape of a quarter. The estimated prevalence of the disorder is approximately 1 in 1000 people, with a lifetime risk of approximately 2 percent. One of the systemic therapies for alopecia areata consists of the use of glucocorticoids or immunosuppressants. Methods: Baricitinib (BCT) is a Janus kinase (JAK) 1 and 2 selective inhibitor used as an immunosuppressant drug. In this study, three olive oil BCT formulations (Oil A, Oil B, and Oil C, which differ in their content in squalene, tocopherol, tyrosol, and hydroxytyrosol) have been developed for topical delivery. The formulations were physicochemically characterized and the in vitro drug release and ex vivo permeation through human skin tissues were assessed. Results: The results showed nearly identical viscosity across all three formulations, exhibiting Newtonian behavior. The mathematical modeling used to describe the drug release profiles was the one-site binding hyperbola for all formulations. Oil-based formulations showed a slow BCT penetration into human skin. Skin integrity remained intact during the experiments, with no signs of irritation or alterations observed. In addition, all the formulations proved their efficacy in vivo. Conclusions: Among the formulations, Oil A demonstrated the highest ability retention capacity (Q_r = 1875 ± 124.32 ng/cm²) in the skin, making it an excellent candidate for further investigation in the treatment of alopecia areata. Full article

Background: Attracting and retaining sufficient numbers of nurses is an international challenge. The group most difficult to retain are newly qualified nurses within their first five years of practice or earlier. A recent US study reported that approximately 25 percent of nurses leave within the first year of graduation. Health organisations play a crucial role in providing workplace cultures where nurses feel empowered and can thrive. Research needs to focus on improving organisational culture, yet most approaches to supporting and retaining nurses have used top–down, management-designed interventions. This article describes a collaborative international programme of research. Methods: This innovative international theory-driven multi-site action research programme adopts a longitudinal co-design approach based on principles of appreciative inquiry to develop and implement organisational support for newly qualified nurses. It integrates the Institute for Health Improvement (IHI) Framework for Improving Joy at Work and the Thriving at Work model, both focused on improving the well-being of the healthcare workforce and health service outcomes. Each year, a new group of nurses during their first-year orientation is invited to participate. Over five years, each cohort will then participate in an annual survey, focus groups, and co-design meetings with nurse leaders/managers, generating new solutions developed through open dialogue for subsequent testing driven by these key stakeholders. Expected outcomes: This research will generate a new co-design management model to improve systems of support that may assist nurse retention and thriving that can be shared with other nursing organisations. It will provide an understanding of the effectiveness of current support for nurses by their employers from the perspective of those nurses whilst providing evidence about what extra support nurses would like from their employers. Conclusions: This international research programme gives agency to nurses and organisational nurse leaders/managers to co-design interventions for building positive work environments where early-career nurses can thrive. This programme will capture what works, where, how, and with whom, ultimately benefiting both individual nurses and the overall effectiveness and sustainability of healthcare systems. Full article

Chia seeds have emerged as a promising natural substitute for eggs in various baked products due to their unique gelling properties and ability to bind ingredients. Their gelling abilities closely mimic the moisture-retention functions of eggs in baked goods. The growing interest in plant-based alternatives creates a larger market for more sustainable foods. However, negative sensory attributes are found in baked goods with high chia seed content. The objective of this research was to explore the acceptance of chia gel as an egg replacer in brownies by documenting changes in product quality and chia functionality as an egg substitute. Brownies were made using Ghirardelli brownie mix, with two applied treatments containing chia gel, replacing 50 and 100 percent eggs (w/w). A sensory evaluation was performed with 120 participants to document their levels of acceptance of five attributes with a five-point hedonic scale: appearance, color, texture, consumer overall opinion, and purchase willingness. There were no significant differences between the 50% (w/w) substitution and control (p > 0.05). A 100% (w/w) substitution showed low acceptance for each attribute except aroma (p < 0.05). Flavor and taste were found to be leading determinants of overall opinion and purchase willingness (p < 0.05). These results highlighted the potential for chia seeds to be a viable alternative when replacing up to half of the egg content in brownies, while still maintaining sensory quality and satisfaction. Future research will explore the rheological properties of chia seed gels and their interaction with macro-/micro molecules in different food systems. Full article

Trillium Health Partners (THP) is a hospital network that serves the Mississauga region of Ontario, Canada, and sees nearly 1.7 million patient visits each year. THP is also a provider of highly specialized services to the region and a fully-fledged academic teaching center, with embedded research and innovation. Background/Objectives: Highly trained, skilled, and experienced nurses are foundational to THPs ability to meet the complex care needs of our patients across specialized programs. In 2024, 50% of the nursing workforce at THP was noted to have less than five years of experience. This generation of nurses are reporting high levels of burnout and are at greater risk of leaving the profession. The more experienced nurses are also facing burnout due to the continued pressures and demands in the workplace, having to manage an increasingly complex patient assignment, while providing mentorship to more novice nurses. Based on the existing literature and our collective experience at THP, we have developed the Transition to Independent Practice Support (TIPS) program, a multi-pronged approach to bolster support for our nursing workforce. The TIPS program at THP is designed to address knowledge gaps and enhance clinical competence among new and aspiring nurses. The primary aim of this study is to evaluate the efficacy of the TIPS program in facilitating the transition of novice nurses to independent and competent practitioners, utilizing the Kirkpatrick Model of Evaluation The specific objectives include (a) assessing participants’ reactions to the TIPS program; (b) measuring the increase in nurses’ knowledge and confidence following program participation; (c) evaluating changes in nurses’ behavior and practice post-program; and (d) determining the program’s impact on nurse retention and quality of patient care. Methods: Grounded in Meleis’s Transition Theory, the program combines webinars, simulations, clinical rounding, and mentorship to build resilience, decision-making, and confidence. Evaluative measures, based on the Kirkpatrick Model, assessed participant satisfaction, learning outcomes, behavior changes, and retention. Results: From September 2023 to March 2024, 388 interdisciplinary participants attended the program, including nursing students (56%), registered nurses (24%), registered practical nurses (14%), and aspiring nurses in other interprofessional roles (6%). Participants expressed high satisfaction with the program, achieving a mean reaction score of 4.80 (SD = 0.2921). Ninety-five percent found the sessions relevant, and 98% rated the facilitators as knowledgeable. Self-reported confidence significantly increased across all topics, with overall mean confidence scores rising from 2.94 to 4.52 (p < 0.0001, Cohen’s d = 3.01), demonstrating a strong impact on skill acquisition and application. Behavioral evaluations through simulations, competency checklists, and follow-up touchpoints confirmed improved clinical performance, with participants achieving 100% compliance to nursing skills during simulations and sustained confidence at three-month follow-ups. Since the program’s implementation, nursing turnover rates decreased from 9.52% to 7.7% by March 2024, with 100% of RNs, RPNs and IENs of TIPS participants retained within six months. Conclusions: This paper outlines the TIPS program and the diverse teaching and learning methodologies used in the design and program implementation to ultimately support the transition experience of the new gradate nurse into acute care. Preliminary outcomes are discussed including nursing retention rates, nurses’ knowledge, confidence, and skill levels. Full article

Liver cancer is a prevalent form of carcinoma worldwide. A novel chitosan-coated optimized formulation capped with irradiated silver nanoparticles (INops) was fabricated to boost the anti-malignant impact of rosuvastatin calcium (RC). Using a 2³-factorial design, eight formulations were produced using the solvent evaporation process. The formulations were characterized in vitro to identify the optimal formulation (Nop). The FTIR spectra showed that the fingerprint region is not superimposed with that of the drug; DSC thermal analysis depicted a negligible peak shift; and XRPD diffractograms revealed the disappearance of the typical drug peaks. Nop had an entrapment efficiency percent (EE%) of 86.2%, a polydispersity index (PDI) of 0.254, a zeta potential (ZP) of −35.3 mV, and a drug release after 12 h (Q12) of 55.6%. The chitosan-coated optimized formulation (CS.Nop) showed significant mucoadhesive strength that was 1.7-fold greater than Nop. Physical stability analysis of CS.Nop revealed negligible alterations in VS, ZP, PDI, and drug retention (DR) at 4 °C. The irradiated chitosan-coated optimized formulation capped with silver nanoparticles (INops) revealed the highest inhibition effect on carcinoma cells (97.12%) compared to the chitosan-coated optimized formulation (CS.Nop; 81.64) and chitosan-coated optimized formulation capped with silver nanoparticles (CS.Nop.AgNPs; 92.41). The bioavailability of CS-Nop was 4.95-fold greater than RC, with a residence time of about twice the free drug. CS.Nop has displayed a strong in vitro–in vivo correlation with R² 0.9887. The authors could propose that novel INop could serve as an advanced platform to improve oral bioavailability and enhance hepatic carcinoma recovery. Full article

Water pollution is a major global issue, and antibiotic drugs released into aquatic environments by the pharmaceutical industry, such as ciprofloxacin, have negative consequences on both human health and the ecosystem. In this study, the performance of PVA as a polymer ligand for ciprofloxacin (CPFX) removal is evaluated through polymer-enhanced ultrafiltration using a novel composite PVC-ZnO membrane. The initial concentration of the ciprofloxacin solution, pH, ionic strength, ideal polymer concentration, duration, and maximum retention capacity were among the factors that were examined. In order to remove ciprofloxacin from water, PVA is utilized as a polymeric binding agent in a complex manufacturing process. In this instance, the PVC-ZnO membrane with 1.0 weight percent ZnO had a 96.77% ciprofloxacin clearance rate. PVA polymer has a high clearance rate of 99.98% in 1wt% of ZnO in this composite membrane when added to the ciprofloxacin solution. Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), ultraviolet spectroscopy, and X-ray diffraction (XRD) were used to analyze the production and features of composite PVC-ZnO membranes. It is anticipated that this study’s discussion will be crucial to the development of higher-quality membrane technologies that remove pharmaceutical active chemicals from wastewater in an environmentally responsible manner without endangering the ecosystem. This investigation showed that composite PVC-ZnO membranes were effective materials for efficient removal of ciprofloxacin (CPFX). Full article

Liverwort (Marchantia polymorpha) competes for resources within containers, resulting in a reduction in the quality and market value of ornamentals. Therefore, the objective of this study was (1) to assess the impact of different mulch types, depths, and their moisture-holding-capacity on liverwort control and (2) to quantify if phytotoxicities develop on ornamental plants due to the mulches. The percent water retention of four different organic mulches [rice hull (RH), cocoa hull (CH), pine bark (PB), or red hardwood (HW)] was determined in a laboratory experiment. In a greenhouse experiment, the Hosta plantaginea (Plantain Lily) varieties ‘Curly Fries’ and ‘Pandora’s Box’ were mulched with either RH, HW, CH, or PB at a depth of 0.63, 1.27, 2.54, or 5.08 cm. Liverwort thalli coverage on the container surface was visually estimated bi-weekly, and the fresh weight of the thalli was recorded at the end of the experiment. The results indicated that CH mulch retained the highest amount of moisture (86%). The RH and HW mulches, at depths of 1.27 cm or more, provided excellent (>80%) liverwort control in ‘Curly Fries’. All mulches at depths of 1.27 cm or more showed excellent (100%) liverwort control for ‘Pandora’s Box’. Overall, RH and PB mulches at all depths provided excellent liverwort control and no reduction in the growth of ‘Curly Fries’ and ‘Pandora’s Box’. Full article

Wood modification has been explored in various ways to enhance dimensional stability and reduce flammability, with a focus on environmentally friendly treatments to meet market demands. This study aimed to investigate the efficacy of new, potential fire-retardant materials. Specifically, the study examined the combination of tripotassium citrate (TPC), a water-soluble and bio-based fire retardant, with sorbitol and citric acid (SorCA), an eco-friendly thermosetting resin previously studied. While TPC is known to control combustion, its application in wood modification has not been thoroughly researched. To assess the fixation and flammability of these fire retardants, tests were conducted on Scots Pine (Pinus sylvestris L.), including chemical analysis, dimensional stability, mechanical properties, flame retardancy, and leaching tests. The combination of SorCA and TPC showed high weight percent gain (WPG) values; however, leaching and anti-swelling efficiency (ASE) tests revealed challenges in fixation stability. The dynamic mechanical properties were reduced, whereas the static strength values were in the same range compared with untreated wood. While TPC exhibited high flame retardancy prior to leaching, its efficacy diminished post-leaching, underscoring challenges in fixation and the need for improved retention strategies. Bunsen burner tests conducted on leached specimens indicated enhanced performance even under severe leaching conditions as per the EN 84:2020 procedure. However, cone calorimetry measurements showed less favorable outcomes, emphasizing the necessity for further investigation into optimizing TPC retention and enhancing treatment efficacy. Full article

The purpose of this study was to identify the optimal smash-ridging tillage depth in sugarcane fields in Guangxi, China, in order to improve soil moisture conditions. Three treatments were implemented in sugarcane cultivation areas, with smash-ridging tillage depths of 20 cm, 40 cm, and 60 cm. The dynamics of soil moisture were monitored at depths of 5 cm, 20 cm, and 40 cm to investigate their response to precipitation. The results indicated that the F40 treatment had the highest mean soil moisture content. The F40 treatment exhibited a 29.85% increase in percent area of significant coherence (PASC) compared to the F20 treatment and an 8.23% increase in PASC compared to the F60 treatment. These results indicated that the F40 treatment exhibited the most significant vertical exchange. Under the same precipitation conditions, the F20 and F40 treatments exhibited a quicker soil moisture response to precipitation than the F60 treatment. The mean soil moisture replenishment (SMR) of the F40 treatment was 0.94% and 11.02% higher than that of the F20 and F60 treatments, respectively. Following the torrential rainfall event, the F40 treatment exhibited the slowest recession rate of soil moisture, indicating a greater capacity for water retention. Therefore, the smash-ridging tillage depth of 40 cm resulting in the best responsiveness to precipitation was recommended for sugarcane cultivation in Guangxi, China, which effectively improved soil moisture exchanges. Full article

A new approach was applied for the development of a precise, simple, and economic analytical process for the accurate analysis of tolterodine tartrate (TOT) in its bulk and tablet using HSPiP- and quality by design (QbD)-assisted methods. The HSPiP program predicted several solvents and their right ratios for the mobile phase, followed by simulating the experimental solubility data in various predicted solvents. QbD was used to identify the impact of the composition and the mobile phase flow rate on the peak area and retention time. TOT was estimated using an Agilent TC C₁₈ column employing an optimized mobile phase. The HSPiP shortened the solvent selection time with high reliability, whereas QbD identified critical factors. The optimized composition and process variables were used to develop an analytical method for TOT estimation. Various analytical validation parameters were estimated with constructed linearity of 5–30 μg/mL and a percent recovery yield value of 100.36%. To ensure the reliability of the optimized method, we estimated validation parameters (linearity, specificity, precision, accuracy, robustness, and ruggedness) to comply with the ICH guidelines. Considering the high recovery yield, good regression coefficient, low detection limit, and low noise ratio, the optimized method was accurate and precise with a high degree of specificity, rapid process, and reproducibility for the quantitative estimation of tolterodine from both oral analytes (I and II). The validated method was implemented for pharmacokinetic study in rats for quantitative estimation of the analytes with high accuracy, sensitivity, and reproducibility. Full article

Background: Obesity is commonly aggregated with indices of metabolic health. Proponents of body positivity approaches question whether body size is a determinant of health and well-being. Our objective was to conduct an exploratory factor analysis (EFA) to determine if body size measurements factor load with or independent of metabolic health measures. Methods: The EFA was conducted on n= 249 adults using baseline data from four weight loss trials (Sample 1: n = 40; Sample 2: n = 52; Sample 3: n = 53; Sample 4: n = 104). An EFA of nine items (systolic blood pressure [SBP], diastolic blood pressure [DBP], hemoglobin A1c [HbA1c], HDL-cholesterol [HDL], LDL-cholesterol [LDL], total cholesterol [TC], body mass index [BMI], body fat percent BF%], and waist circumference [WC]) was conducted with oblique rotation. Results: Three factors were retained, which produced a model explaining 87.5% of the variance. Six items loaded strongly (>0.8) under three components and were selected for retention (Factor 1: LDL and TC; Factor 2: BMI and WC; Factor 3: SBP and DBP). Conclusion: Body size measures loaded separately from measures of metabolic health and metabolic health were further split into lipid- and blood pressure-focused factors. These results support weight-neutral interventions to improve overall health and well-being. Full article