Search Results (4)

This study serves as a research endeavor aiming to explore the behavior of the coupling flow effects of the single expansion ramp nozzle (SERN) in over-expansion conditions during the static start-up process. The open-source program OpenFOAM and its solver “rhoCentralFoam” are employed in the 2D simulation and the two critical geometric variations, the shape of the ramp and the length of the flap beyond the throat, are considered in the geometric variation. The result shows the preferable propulsion performance in the FSS (Free Shockwave Separation) state compared to RSS (Restricted Shockwave Separation). FSS also plays the role of the initial, albeit transient, separation, which originates from the shockwave from the throat and will eventually transform into a stabler RSS state. For the 100% flap length configuration in this study, the axial thrust can achieve a high value of 500 N/m in the FSS state and decrease to around 450 N/m, on average, in the RSS state. The trust angle also shows a preferable performance of around −13° in FSS compared to −30° in RSS. Regarding geometric modifications, both modifications, shorting the flap and bell-shaped ramp adjustments, manifest similar effects. Both conical and bell-shaped short flap configurations demonstrate an axial thrust from around 1750 to 1900 N/m and a thrust angle of around −45°. However, the flap shortening, which may demonstrate an attitude compensation effect, exhibits a more pronounced effect compared to the bell-shaped modification. Full article

Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal Muscular Atrophy (SMA), cerebral adrenoleukodystrophy, β-Thalassemia, hemophilia A/B, retinal dystrophy, and Duchenne Muscular Dystrophy have generated buzz around the ability to change the course of genetic syndromes. However, this excitement risks over-expansion into areas of genetic disease that may not fit the current state of gene therapy. While in situ (targeted to an area) and ex vivo (removal of cells, delivery, and administration of cells) approaches show promise, they have a limited target ability. Broader in vivo gene therapy trials have shown various continued challenges, including immune response, use of immune suppressants correlating to secondary infections, unknown outcomes of overexpression, and challenges in driving tissue-specific corrections. Viral delivery systems can be associated with adverse outcomes such as hepatotoxicity and lethality if uncontrolled. In some cases, these risks are far outweighed by the potentially lethal syndromes for which these systems are being developed. Therefore, it is critical to evaluate the field of genetic diseases to perform cost–benefit analyses for gene therapy. In this work, we present the current state while setting forth tools and resources to guide informed directions to avoid foreseeable issues in gene therapy that could prevent the field from continued success. Full article

Flow separation and transitions of separation patterns are common phenomena of nozzles working with a wide Mach range. The maximum thrust method is applied to design the single-expansion ramp nozzle (SERN) for specific operating conditions. The nozzle is used to numerically simulate the transition processes of separation patterns under the linear change in the external flow Mach number and the actual trajectory take-off condition of a rocket-based combined cycle (RBCC), to investigate the mechanism through which the external flow field influences the separation pattern transition during acceleration. The computational fluid dynamics (CFD) method is briefly introduced, followed by experimental validation. Then, the design procedure of SERN is described in detail. The simulation results indicate that as the external Mach number increases, the flow field in the nozzle undergoes transitions from RSS (ramp) to FSS, and finally exhibits a no-flow separation pattern. The rate at which the external Mach number varies has little effect on the transition principle of the nozzle flow separation patterns, but it has a significant effect on the critical Mach number of the transition points. The external flow field of the nozzle has an airflow accumulation effect during acceleration, which can delay the transition of the flow separation pattern. Full article

This study investigated the effect of the built-in volume ratio of an expander on the performance of a dual-loop Rankine cycle system for the engine waste heat recovery of a vehicle. Varying vehicle operating conditions can cause a positive displacement expander to operate in both under- and over-expansion states. Therefore, analysis of the off-design performance of the expander is very important. Furthermore, the volume and weight of the expander must be considered in its optimization along with the efficiency. A simple modeling of the off-design operation of the expander showed that a built-in volume ratio that causes under-expansion rather than over-expansion at the target condition is more desirable. Full article