Search Results (4)

Aerostatic bearings are crucial support components in ultra−precision manufacturing equipment. However, improvements in the load−carrying capability (LCC) of aerostatic bearings often lead to higher intensity nano−vibrations. This paper introduces a novel primary and secondary orifice restrictor (PSOR) designed to simultaneously enhance the LCC and mitigate nano−vibrations in aerostatic bearings. The static performance of complex turbulent flows occurring within the chamber of aerostatic bearings with PSORs was investigated. The dynamic performance of the turbulent flows was analyzed through 3D transient numerical simulation using the large eddy simulation method. The LCC and nano−vibration acceleration were measured experimentally, and the results indicated that the design of the secondary orifice diameter could enhance LCC and mitigate nano−vibrations, consistent with theoretical predictions. The accuracy of the proposed model was validated, confirming the effectiveness of PSOR. In the experiments, an aerostatic bearing with a secondary orifice diameter of 0.1 mm exhibited the lowest LCC and largest nano−vibration. Conversely, an aerostatic bearing with a secondary orifice diameter of 0.26 mm exhibited the highest LCC and weakest nano−vibration. This study provides insights into the formation mechanism of turbulent vortex and interaction mechanism among the primary orifice and secondary orifices in aerostatic bearings with a PSOR. Full article

(1) Background: A novel bioreactor platform of neuronal cell cultures using low-magnitude, low-frequency (LMLF) vibrational stimulation was designed to discover vibration influence and mimic the dynamic environment of the in vivo state. To better understand the impact of 40 Hz and 100 Hz vibration on cell differentiation, we join biotechnology and advanced medical technology to design the nano-vibration system. The influence of vibration on the development of nervous tissue on the selected cell line SH-SY5Y (experimental research model in Alzheimer’s and Parkinson’s) was investigated. (2) Methods: The vibration stimulation of cell differentiation and elongation of their neuritis were monitored. We measured how vibrations affect the morphology and differentiation of nerve cells in vitro. (3) Results: The highest average length of neurites was observed in response to the 40 Hz vibration on the collagen surface in the differentiating medium, but cells response did not increase with vibration frequency. Also, vibrations at a frequency of 40 Hz or 100 Hz did not affect the average density of neurites. 100 Hz vibration increased the neurites density significantly with time for cultures on collagen and non-collagen surfaces. The exposure of neuronal cells to 40 Hz and 100 Hz vibration enhanced cell differentiation. The 40 Hz vibration has the best impact on neuronal-like cell growth and differentiation. (4) Conclusions: The data demonstrated that exposure to neuronal cells to 40 Hz and 100 Hz vibration enhanced cell differentiation and proliferation. This positive impact of vibration can be used in tissue engineering and regenerative medicine. It is planned to optimize the processes and study its molecular mechanisms concerning carrying out the research. Full article

Slide stability is key to the aerostatic guide in ultra-precise machines; thus, it has garnered plenty of attention. Macro-scale studies are commonplace, but micro- and nano-vibration issues require more attention. Microscope vibration is mainly caused by tiny changes in the fluid parameters of lubricating gas film, which is complex and has no verdict. In this case, slide-gas interaction should be considered. In this study, the widely used orifice-type restrictor was investigated for its nano-vibration performance. A Comsol finite-element-method fluid–structure interaction model was used to simulate and analyze an orifice-type restrictor, and orifice-restrictor vibration characteristics at the nanometer scale were inspected using a high-performance laser vibrometer. The results demonstrate that see-saw mode vibrations occur in the restrictors, growing stronger with increased air-supply pressure. The see-saw vibration’s axis is speculatively determined based on orifice and restrictor structures, and the vibration type is related to the number of orifices. The results also show that the vibration is random with natural frequencies at the kilohertz level. The newly provided research results are beneficial for better understanding the nano-vibrations of orifice-type restrictors. Full article

Adult or mesenchymal stem cells (MSCs) have been found in different tissues in the body, residing in stem cell microenvironments called “stem cell niches”. They play different roles but their main activity is to maintain tissue homeostasis and repair throughout the lifetime of an organism. Their ability to differentiate into different cell types makes them an ideal tool to study tissue development and to use them in cell-based therapies. This differentiation process is subject to both internal and external forces at the nanoscale level and this response of stem cells to nanostimuli is the focus of this review. Full article