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J. Funct. Biomater. 2015, 6(3), 598-622;

Adult Stem Cell Responses to Nanostimuli

Centre for Cell Engineering, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
Academic Editor: Francesco Puoci
Received: 16 March 2015 / Revised: 29 June 2015 / Accepted: 8 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Feature Papers)
Full-Text   |   PDF [2097 KB, uploaded 17 July 2015]   |  


Adult or mesenchymal stem cells (MSCs) have been found in different tissues in the body, residing in stem cell microenvironments called “stem cell niches”. They play different roles but their main activity is to maintain tissue homeostasis and repair throughout the lifetime of an organism. Their ability to differentiate into different cell types makes them an ideal tool to study tissue development and to use them in cell-based therapies. This differentiation process is subject to both internal and external forces at the nanoscale level and this response of stem cells to nanostimuli is the focus of this review. View Full-Text
Keywords: stem cells; stem cell niche; MSC; nanoforces; nanotopography; nanovibration; mechanotransduction; ECM; cell adhesion stem cells; stem cell niche; MSC; nanoforces; nanotopography; nanovibration; mechanotransduction; ECM; cell adhesion

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Tsimbouri, P.M. Adult Stem Cell Responses to Nanostimuli. J. Funct. Biomater. 2015, 6, 598-622.

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