Search Results (23)

Reducing structural mass and volume is critical to improving efficiency and payload capacity in next-generation small satellites and CubeSats. Additive manufacturing, particularly material extrusion, offers design flexibility and enables the production of lightweight, functional metallic components. This study investigates the integration of nickel–titanium shape memory alloy wires into aluminum-based matrices using a sinter-based material extrusion process, aiming to develop compact actuator systems for aerospace applications. A customized AlSi7Mg aluminum alloy feedstock was extruded into filament form, printed, and embedded with shape memory alloy wires, allowing consolidation during sintering. X-ray micro-computed tomography was used to analyze internal defects and matrix–wire interfacial contact, before and after sintering. Tensile testing of the embedded actuator structures revealed effective mechanical bonding and actuation behavior. The results demonstrate that controlled shrinkage and interfacial bonding enable reliable embedding of shape memory elements without compromising structural integrity. This work provides a promising framework for developing multifunctional aerospace components, where active actuation and structural efficiency can be combined through advanced material extrusion-based manufacturing. Full article

Sustainability and resource optimization have spurred interest in giving a second life to used equipment, often discarded after limited use. Within this framework, we conducted a multidisciplinary, final-year engineering project to explore the reverse engineering and repurposing of commercial hoverboards for an auto-stabilizing, modular robotic platform, with emphasis on medical applications such as transporting medication. The innovation lies in recycling hoverboards to develop a teleoperated, stabilized base that can accommodate additional modules—for instance, a multifunctional arm or a transport shelf—akin to existing commercial robots. Our methodology involves disassembling and reprogramming the hoverboard’s motor controllers and sensors to maintain horizontal stability. Control is realized through the sensor fusion of accelerometer and gyroscope data, processed by a Kalman filter and implemented in a Proportional-Integral-Derivative (PID) loop. A user-friendly Human-Machine Interface (HMI), hosted on an ESP32 microcontroller, enables remote operation and monitoring. Experimental results show that the platform autonomously balances, carries payloads, and achieves high energy efficiency, highlighting its potential as a sustainable and versatile solution in modular robotic applications. Full article

Low-cost MEMS sensors are widely utilized in UAV platforms to address attitude estimation problems due to their compact size, low power consumption, and cost-effectiveness. Diverse UAV payloads pose new challenges for attitude estimation, such as magnetic interference environments and high dynamic environments. In this paper, we propose a hierarchical decoupled attitude estimation algorithm, termed HDAEA. Initially, a novel hierarchical decoupling approach is introduced for the attitude and angle representation of the direction cosine matrix, enabling the representation of angles in a new manner. This method reduces the data dimensionality and nonlinearity of observation equations. Furthermore, a magnetic interference identification algorithm is proposed to compute the magnetic interference intensity accurately and quantitatively. Combining the quantified errors of estimated state variables, an error model for magnetic interference and attitude angles in high-dynamic environments is constructed. Subsequently, the proposed error model is employed to calibrate the hierarchical decoupled angles using accelerometer and magnetometer measurements, effectively mitigating the impact of magnetic interference on the calculation of pitch angles and roll angles. Moreover, the integration of the proposed hierarchical decoupled attitude estimation algorithm with the error-state extended Kalman filter reduces system nonlinearity and minimizes linearization errors. Experimental results demonstrate that HDAEA exhibits significantly improved attitude estimation accuracy of UAV payloads. Full article

The present work aims to develop the current CubeSats architecture. Starting from the framework of project ARAMIS (an Italian acronym for a highly modular architecture for satellite infrastructures), a new concept of smart tiles has been developed, employing multifunctional structures and lightweight, composite materials. This enables increased CubeSat mass efficiency and payload volume. An embedded battery tile has been designed, built, and tested from a vibration point of view. In the present work, the LiPo batteries selected for the prototype have been tested with the HPPC testing procedure, to extract their equivalent Randles circuit parameters. Thus, the thermal power dissipation from the batteries can be estimated. With these data, Thermal Desktop simulations of a representative ARAMIS CubeSat are performed, considering LEO orbit and hot/cold cases. Firstly, a parametric analysis was conducted to evaluate the thermal behaviors of various design alternatives. A suitable configuration for the CubeSat was then found, enabling the validation of the embedded battery tile from a thermal point of view. The final configuration includes heaters for the LiPo batteries, a commercial CubeSat skeleton made in aluminum alloy, and a top coating for smart tiles with proper solar absorptivity. Full article

The remotely operated vehicle (ROV), a vital deep-sea platform, offers key advantages, including operational duration via continuous umbilical power, high task adaptability, and zero human risk. It has become indispensable for deep-sea scientific research and marine engineering. To enhance surveys of cobalt-rich crusts (CRCs) on complex seamount terrains, the 4500-m-class Haima ROV integrates advanced payloads, such as underwater positioning systems, multi-angle cameras, multi-functional manipulators, subsea shallow drilling systems, sediment samplers, and acoustic crust thickness gauges. Coordinated control between deck monitoring and subsea units enables stable multi-task execution within single dives, significantly improving operational efficiency. Survey results from Caiwei Guyot reveal the following: (1) ROV-collected data were highly reliable, with high-definition video mapping CRCs distribution across varied terrains. Captured crust-bearing rocks weighed up to 78 kg, drilled cores reached 110 cm, and acoustic thickness measurements had a 1–2 cm margin of error compared to in situ cores; (2) Video and cores analysis showed summit platforms (3–5° slopes) dominated by tabular crusts with gravel-type counterparts, summit margins (5–10° slopes) hosting gravel crusts partially covered by sediment, and steep slopes (12–15° slopes) exhibiting mixed crust types under sediment coverage. Thicker crusts clustered at summit margins (14 and 15 cm, respectively) compared to thinner crusts on platforms and slopes (10 and 7 cm, respectively). The Haima ROV successfully investigated CRC resources in complex terrains, laying the groundwork for seamount crust resource evaluations. Future advancements will focus on high-precision navigation and control, high-resolution crust thickness measurement, optical imaging optimization, and AI-enhanced image recognition. Full article

The annular flow payload is among the first batch of space science experimental projects carried out on the Fluid Physics Rack of the China Space Station. This paper provides a detailed introduction to the development of the payload, ground validation, and in orbit experiments. The payload, sized 320 mm × 200 mm × 220 mm, includes an annular flow model and supports supply (24 V, 12 V, and 5 V), communication, and data transmission. A multi-functional heating column in the annular flow model was designed, allowing for the column to operate in fixed, rotating, and lifting scenarios. In the first round, 96 sets of space experiments covering volume ratio ranges from 0.45 to 1.06 were carried out. The annular flow liquid surface state, temperature oscillation, and infrared temperature field evolution were obtained. Mode decomposition shows the oscillatory convection of the m = 4 travelling wave, and contains m = 3, m = 6, and m = 8 waves. Full article

Smart radiotherapy biomaterials (SRBs) include seed and liquid biomaterials designed to be employed as fiducial markers during radiotherapy while also delivering therapeutic drug payloads to enhance treatment outcomes. In this study, we investigate a novel Customizable Lyophilized Agent for Radiotherapy Imaging and TherapY (CLARITY) biomaterial, which can be loaded with immunoadjuvants (anti-CD40 monoclonal antibody or Caflanone (FBL-03G)) at the point of care. The CLARITY biomaterial was investigated in an animal model of pancreatic cancer using C57BL6 mice. Mice were imaged before and at different points of time post-treatment to evaluate the potential of CLARITY biomaterial to provide imaging contrast similar to fiducials. This study also used cadavers to assess CLARITY’s potential to provide imaging contrast in humans. Results showed imaging contrast from computed tomography (CT) and magnetic resonance imaging (MRI) modalities for up to 30 days post-treatment, demonstrating potential for use as fiducials. A significant increase in survival (***, p = 0.0006) was observed for mice treated with CLARITY biomaterial loaded with immunoadjuvant for up to 10 weeks post-treatment compared to those without treatment. These initial results demonstrate the potential of CLARITY biomaterial to serve as a smart multifunctional radiotherapy biomaterial and provide the impetus for further development and optimization as a point-of-care technology for combination radiotherapy and immunotherapy. Full article

The development of a soft crawling robot (SCR) capable of quick folding and recovery has important application value in the field of biomimetic engineering. This article proposes an origami-inspired vacuum-actuated foldable soft crawling robot (OVFSCR), which is composed of entirely soft foldable mirrored origami actuators with a Kresling crease pattern, and possesses capabilities of realizing multimodal locomotion incorporating crawling, climbing, and turning movements. The OVFSCR is characterized by producing periodically foldable and restorable body deformation, and its asymmetric structural design of low front and high rear hexahedral feet creates a friction difference between the two feet and contact surface to enable unidirectional movement. Combining an actuation control sequence with an asymmetrical structural design, the body deformation and feet in contact with ground can be coordinated to realize quick continuous forward crawling locomotion. Furthermore, an efficient dynamic model is developed to characterize the OVFSCR’s motion capability. The robot demonstrates multifunctional characteristics, including crawling on a flat surface at an average speed of 11.9 mm/s, climbing a slope of 3°, carrying a certain payload, navigating inside straight and curved round tubes, removing obstacles, and traversing different media. It is revealed that the OVFSCR can imitate contractile deformation and crawling mode exhibited by soft biological worms. Our study contributes to paving avenues for practical applications in adaptive navigation, exploration, and inspection of soft robots in some uncharted territory. Full article

Current CubeSats usually exhibit a low structural mass efficiency and a low internal volume for their payloads. The present work aims to propose an advanced structural architecture for CubeSats that addresses the issues of low structural mass efficiency and payload volume. The starting concept is the smart tiles architecture for satellites developed for the ARAMIS (an Italian acronym for a highly modular architecture for satellite infrastructures) CubeSat project. By introducing multifunctional structures and lightweight, composite materials in the design of smart tiles, the volumetric and structural mass efficiency of the entire CubeSat are enhanced. The advantages of the chosen approach are preliminarily analyzed in terms of the volumetric efficiency and amplitude of the payload design space. A 1U battery tile design is then selected to investigate the multifunctional structures design aspects in the project of space structures. A battery tile prototype is designed, produced, and tested. The CubeSat volumetric increment and the payload volume gain with respect to the traditional architecture is shown to reach a maximum of 37%. The CubeSat structural mass ratio can be reduced to 16.7%. Full article

Antibody–drug Conjugates (ADCs) are a powerful therapeutic modality for cancer treatment. ADCs are multi-functional biologics in which a disease-targeting antibody is conjugated to an effector payload molecule via a linker. The success of currently used ADCs has been largely attributed to the development of linker systems, which allow for the targeted release of cytocidal payload drugs inside cancer cells. Many lysosomal proteases are over expressed in human cancers. They can effectively cleave a variety of peptide sequences, which can be exploited for the design of ADC linker systems. As a well-established linker, valine-citrulline-p-aminobenzyl carbamate (ValCitPABC) is used in many ADCs that are already approved or under preclinical and clinical development. Although ValCitPABC and related linkers are readily cleaved by cathepsins in the lysosome while remaining reasonably stable in human plasma, many studies have shown that they are susceptible to carboxylesterase 1C (Ces1C) in mouse and rat plasma, which hinders the preclinical evaluation of ADCs. Furthermore, neutropenia and thrombocytopenia, two of the most commonly observed dose-limiting adverse effects of ADCs, are believed to result from the premature hydrolysis of ValCitPABC by human neutrophil elastase. In addition to ValCitPABC, the GGFG tetrapeptidyl-aminomethoxy linker is also cathepsin-cleavable and is used in the highly successful ADC drug, DS8201a. In addition to cathepsin-cleavable linkers, there is also growing interest in legumain-sensitive linkers for ADC development. Increasing plasma stability while maintaining lysosomal cleavability of ADC linkers is an objective of intensive current research. This review reports recent advances in the design and structure–activity relationship studies of various peptide/peptidomimetic linkers in this field. Full article

Flapping Wing Air Vehicles (FWAVs) have proven to be attractive alternatives to fixed wing and rotary air vehicles at low speeds because of their bio-inspired ability to hover and maneuver. However, in the past, they have not been able to reach their full potential due to limitations in wing control and payload capacity, which also has limited endurance. Many previous FWAVs used a single actuator that couples and synchronizes motions of the wings to flap both wings, resulting in only variable rate flapping control at a constant amplitude. Independent wing control is achieved using two servo actuators that enable wing motions for FWAVs by programming positions and velocities to achieve desired wing shapes and associated aerodynamic forces. However, having two actuators integrated into the flying platform significantly increases its weight and makes it more challenging to achieve flight than a single actuator. This article presents a retrospective overview of five different designs from the “Robo Raven” family based on our previously published work. The first FWAVs utilize two servo motors to achieve independent wing control. The basic platform is capable of successfully performing dives, flips, and button hook turns, which demonstrates the potential maneuverability afforded by the independently actuated and controlled wings. Subsequent designs in the Robo Raven family were able to use multifunctional wings to harvest solar energy to overcome limitations on endurance, use on-board decision-making capabilities to perform maneuvers autonomously, and use mixed-mode propulsion to increase payload capacity by exploiting the benefits of fixed and flapping wing flight. This article elucidates how each successive version of the Robo Raven platform built upon the findings from previous generations. The Robo Raven family collectively addresses requirements related to control autonomy, energy autonomy, and maneuverability. We conclude this article by identifying new opportunities for research in avian-scale flapping wing aerial vehicles. Full article

Dendronized nanoparticles, also called nanoparticle-cored dendrimers, combine the advantages of nanoparticles and dendrimers. These very stable and polyvalent nanoparticles can be used for diverse applications. One such application is drug delivery, because the dendrons can enhance the density of the payload. In this report, we describe the design of multifunctional gold nanoparticles (AuNPs) coated with poly(propylene imine) (PPI) dendrons that contain both prostate cancer active targeting and chemotherapeutic drugs. The PPI dendron is a good candidate for the design of drug delivery vehicles because of its ability to induce a proton sponge effect that will enhance lysosomal escape and intracellular therapeutic delivery. The chemotherapeutic drug used is doxorubicin (DOX), and it was linked to the dendron through a hydrazone acid-sensitive bond. Subsequent acidification of the AuNP system to a pH of 4–5 resulted in the release of 140 DOX drugs per nanoparticles. In addition, the PPI dendron was conjugated via “click” chemistry to an EphA2-targeting antibody fragment that has been shown to target prostate cancer cells. In vitro cell viability assays revealed an IC50 of 0.9 nM for the targeted DOX-bearing AuNPs after 48 h incubation with PC3 cells. These results are very promising upon optimization of the system. Full article

Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance. To overcome this, we coated oncolytic vaccinia viruses (oVV) with erythrocyte-derived membranes (EDMs), hypothesizing that they would not only remain in systemic circulation for longer as erythrocytes would when administered intravenously, but also respond to environmental pH cues due to their membrane surface sialic acid residues. For this, we developed a model based on DLVO theory to show that the acidic moieties on the surface of EDM confers it the ability to respond to pH-based stimuli. We corroborate our modeling results through in vitro cell culture models and show that EDM-coated oVV infects cancer cells faster under acidic conditions akin to the tumor microenvironment. When EDM-coated oVVs were intravenously injected into wild-type mice, they exhibited prolonged circulation at higher concentrations when compared to the unprocessed oVV. Furthermore, when EDM-coated oVV was directly injected into xenografted tumors, we observed that they were suppressed earlier than the tumors that received regular oVV, suggesting that the EDM coating does not hinder oVV infectivity. Overall, we found that EDM was able to serve as a multi-functional encapsulant that allowed the payload to remain in circulation at higher concentrations when administered intravenously while simultaneously exhibiting pH-responsive properties. Full article

We hereby propose the use of stable, biocompatible, and uniformly sized polymeric micelles as high-radiotracer-payload carriers at region-of-interest with negligible background activity due to no or low offsite radiolysis. We modified glycol chitosan (GC) polymer with varying levels of palmitoylation (P) and quaternization (Q). Quaternary ammonium palmitoyl glycol chitosan (GCPQ) with a Q:P ratio of 9:35 (Q9P35GC) offers >99% biocompatibility at 10 mg mL⁻¹. Q9P35GC micelles exhibit >99% ^99mTechnetium (^99mTc) radiolabeling via the stannous chloride reduction method without heat. The ^99mTc-Q9P35GC micelles (65 ± 3 nm) exhibit >98% 6 h serum stability at 37 °C and 7 day of radiochemical stability at 25 °C. HepG2 cells show a higher uptake of FITC-Q9P35GC than Q13P15GC and Q20P15GC. The in vivo 24 h organ cumulated activity (MBq h) order follows: liver (234.4) > kidneys (60.95) > GIT (0.73) > spleen (88.84). The liver to organ ratio remains higher than 2.4, rendering a better contrast in the liver. The radiotracer uptake decreases significantly in fibrotic vs. normal liver, whereas a blocking study with excess Q9P35GC significantly decreases the radiotracer uptake in a healthy vs. fibrotic liver. FITC-Q9P35GC shows in vivo hepato-specific uptake. Radiotracer liver uptake profile follows reversible binding kinetics with data fitting to two-tissue compartmental (2T), and graphical Ichise multilinear analysis (MA2) with lower AIC and higher R² values, respectively. The study concludes that ^99mTc-Q9P35GC can be a robust radiotracer for noninvasive hepatocyte function assessment and diagnosis of liver fibrosis. Furthermore, its multifunctional properties enable it to be a promising platform for nanotheranostic applications. Full article

The main objective of the S-STEP (the Small Synthetic Aperture Radar (SAR) Technology Experimental Project (S-STEP)) mission is developing an 80-kg-class active X-band SAR observation small satellite. For lighter, smaller, better, and cheaper development of the S-STEP system, a new thermal design strategy is essential. Therefore, we proposed a new thermal design strategy in this study. The main features of the proposed thermal design involve the minimization of heater power consumption by optimizing environmental heat fluxes on the satellite, the provision of long-term SAR imaging duration in both right- and left-looking modes, and the use of a lightweight flexible graphite sheet as a thermal interface for some high-power instruments. These features contribute to minimizing the satellite’s mass budget through heater power minimization and achieving on-orbit system performance of S-STEP. The effectiveness of the proposed thermal design was numerically verified by on-orbit thermal analysis of the S-STEP system. In addition, the thermal design on a key payload component and the multifunctional transmit/receive module structure were verified through a space-simulated thermal vacuum test. Full article