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Search Results (526)

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Keywords = ligament reconstruction

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13 pages, 369 KB  
Article
One-Stage Versus Two-Stage ACL Reconstruction with Concomitant MCL Surgery in Combined ACL and MCL Injuries: A Minimum 2-Year Follow-Up Study
by Kwangho Chung, Hyun-Soo Moon, Sung-Hwan Kim, Seung Ho Yoon and Min Jung
J. Clin. Med. 2026, 15(2), 583; https://doi.org/10.3390/jcm15020583 (registering DOI) - 11 Jan 2026
Abstract
Background: The optimal timing and staging of anterior cruciate ligament reconstruction (ACLR) in patients with concomitant medial collateral ligament (MCL) injury remain controversial. This study aimed to compare clinical outcomes between a one-stage ACLR group and a two-stage ACLR group in patients with [...] Read more.
Background: The optimal timing and staging of anterior cruciate ligament reconstruction (ACLR) in patients with concomitant medial collateral ligament (MCL) injury remain controversial. This study aimed to compare clinical outcomes between a one-stage ACLR group and a two-stage ACLR group in patients with combined ACL and MCL injuries in which the MCL was surgically managed. Methods: This retrospective study included 68 patients with combined ACL and grade III MCL injuries treated with ACLR and MCL surgery. Patients were divided into the one-stage ACLR group (n = 42) and the two-stage ACLR group (n = 26) according to the timing and staging of ACLR relative to MCL surgery. Clinical outcomes, including knee stability, patient-reported outcomes, and range of motion (ROM), were compared between groups. Results: After a minimum 2-year follow-up, both groups demonstrated significant improvements in clinical and stability outcomes, with enhanced anterior knee stability, improved patient-reported outcomes, and better objectively assessed knee function. No significant differences were found between groups in anterior, valgus (one-stage: 1.8 ± 1.1 mm, two-stage: 2.3 ± 1.3 mm; p = 0.160), or rotational stability. Likewise, there were no significant differences in mean flexion deficits (one-stage: 2.6 ± 4.1°, two-stage: 1.0 ± 2.0°; p = 0.137), mean extension deficits (one-stage: 1.5 ± 2.5°, two-stage: 1.3 ± 2.0°; p = 0.137), flexion deficits ≥10° (one-stage: 9.5% [4/42], two-stage: 0%; p = 0.290), extension deficits ≥ 5° (one-stage: 9.5% [4/42], two-stage: 3.8% [1/26]; p = 0.642), or additional procedures for postoperative stiffness (one-stage: 16.7% [7/42], two-stage: 11.5% [3/26]; p = 0.730). Patient-reported outcomes, including the Lysholm and IKDC subjective scores, were also comparable between groups. Conclusions: Both the one-stage ACLR group and the two-stage ACLR group for surgically managed combined ACL and MCL injuries yielded comparable clinical and stability outcomes, suggesting that one-stage ACLR can be performed without an apparent increase in the risk of postoperative stiffness or ROM limitations. However, given the limited sample size, these results should be interpreted cautiously because the study may have been insufficiently powered to detect small clinically meaningful differences. Full article
(This article belongs to the Special Issue Clinical Perspectives on Surgical Management of Knee Injuries)
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19 pages, 1826 KB  
Article
Evaluation of the Efficacy of an Artificial Intelligence-Based Assessment and Correction System in the Rehabilitation of Patients Following Anterior Cruciate Ligament Reconstruction Surgery
by Tingting Zhu, Ying Huang, Jingjing Pu, Chaolong Wang, Min Ruan, Ping Lu, Xiaojiang Yang, Nirong Bao, Yueying Chen and Aiqin Zhang
J. Clin. Med. 2026, 15(2), 575; https://doi.org/10.3390/jcm15020575 (registering DOI) - 10 Jan 2026
Abstract
Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction is widely recognised as the primary treatment for ACL injuries. However, with the increasing incidence of sports-related injuries and growing demand for rehabilitation services, conventional rehabilitation models—largely reliant on therapists’ experience and subjective assessment—are increasingly insufficient [...] Read more.
Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction is widely recognised as the primary treatment for ACL injuries. However, with the increasing incidence of sports-related injuries and growing demand for rehabilitation services, conventional rehabilitation models—largely reliant on therapists’ experience and subjective assessment—are increasingly insufficient to meet the clinical need for precise and individualised rehabilitation programmes. This study aimed to evaluate the effectiveness of a rehabilitation protocol incorporating an artificial intelligence (AI)-based assessment and correction system on functional recovery following ACL reconstruction. Methods: Using convenience sampling, 80 patients undergoing ACL reconstruction between June to December 2024 were recruited for this randomised controlled trial. Participants were randomly assigned to either a control group (n = 40), which received conventional functional exercise training, or a trial group (n = 40), which received rehabilitation intervention guided by an AI-based assessment and correction system. Knee function scores (Lysholm score, IKDC score), Berg Balance Scale (BBS) scores, joint range of motion (ROM), and rehabilitation exercise compliance scores were collected and analysed 1, 2, 3, and 4 months postoperatively. Results: Compared with the control group, the trial group demonstrated significantly greater improvements in Lysholm score, IKDC score, BBS score, and active knee joint ROM (p < 0.05) at postoperative assessment points. Additionally, rehabilitation exercise adherence was significantly higher in the trial group compared to the control group (p < 0.05). Conclusions: Rehabilitation protocols integrating AI-based assessment and correction systems effectively enhance knee function recovery, joint mobility and balance ability following ACL reconstruction. Moreover, these protocols significantly improve rehabilitation exercise adherence, demonstrating superior efficacy compared to conventional rehabilitation approaches. This digital rehabilitation model represents an efficient and promising intervention for postoperative ACL rehabilitation. Full article
(This article belongs to the Section Clinical Rehabilitation)
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12 pages, 495 KB  
Systematic Review
Postoperative Weight-Bearing, Range-of-Motion Protocols and Knee Biomechanics After Concomitant Posterolateral Meniscal Root Repair with ACL Reconstruction: A Systematic Review
by Thibaut Noailles, Julien Behr, Nicolas Bouguennec, Loïc Geffroy, César Tourtoulou and Alain Meyer
J. Clin. Med. 2026, 15(2), 542; https://doi.org/10.3390/jcm15020542 - 9 Jan 2026
Viewed by 33
Abstract
Background/Objectives: Meniscal root tears, particularly those of the posterolateral root, are frequently associated with anterior cruciate ligament (ACL) injuries and significantly alter load distribution and knee stability. Surgical repair of the posterolateral meniscal root (PLMR) aims to restore normal biomechanics; however, postoperative [...] Read more.
Background/Objectives: Meniscal root tears, particularly those of the posterolateral root, are frequently associated with anterior cruciate ligament (ACL) injuries and significantly alter load distribution and knee stability. Surgical repair of the posterolateral meniscal root (PLMR) aims to restore normal biomechanics; however, postoperative rehabilitation strategies remain heterogeneous. The objective of this systematic review was to describe and analyze postoperative weight-bearing (WB) and range-of-motion (ROM) protocols following concomitant PLMR repair and anterior cruciate ligament reconstruction (ACLR), integrating both clinical and biomechanical perspectives. Methods: This systematic review followed PRISMA guidelines and analyzed biomechanical and clinical studies assessing postoperative WB and ROM management following PLMR repair combined with ACLR. Results: Eleven studies were included, describing heterogeneous postoperative rehabilitation protocols for WB and ROM following posterolateral meniscal root repair with ACLR. Biomechanical data consistently showed that root section increased tibial internal rotation and contact pressure on the lateral tibial plateau, whereas repair restored near-native load sharing. Clinically, most authors recommended non-weight-bearing or toe-touch loading for 4–6 weeks and flexion limited to 0–90° during early rehabilitation. Gradual progression to full loading and motion between 8 and 12 weeks was the most consistent strategy. Conclusions: Although the current evidence is limited and mainly based on low-level studies, available data suggest that a cautious and progressive rehabilitation protocol after PLMR repair with ACLR early controlled motion and delayed full loading may optimize repair healing while protecting graft integrity. Full article
(This article belongs to the Special Issue Clinical Application of Knee Arthroscopy)
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17 pages, 11668 KB  
Article
Can the Spatial Heterogeneity in the Epiligament Explain the Differential Healing Capacities of the ACL and MCL?
by Lyubomir Gaydarski, Boycho Landzhov, Richard Shane Tubbs and Georgi P. Georgiev
J. Clin. Med. 2026, 15(2), 510; https://doi.org/10.3390/jcm15020510 - 8 Jan 2026
Viewed by 145
Abstract
Background: The anterior cruciate ligament (ACL) and medial collateral ligament (MCL) display strikingly different healing behaviors, despite their similar structural roles within the knee. The epiligament (EL)—a vascular and cellular envelope surrounding each ligament—has emerged as a critical determinant of repair capacity. The [...] Read more.
Background: The anterior cruciate ligament (ACL) and medial collateral ligament (MCL) display strikingly different healing behaviors, despite their similar structural roles within the knee. The epiligament (EL)—a vascular and cellular envelope surrounding each ligament—has emerged as a critical determinant of repair capacity. The aim of this study was to perform a region-specific, comparative analysis of EL molecular profiles in the ACL and MCL to elucidate the mechanisms underlying their contrasting reparative outcomes. Methods: Human ACL and MCL specimens were obtained from 12 fresh knee joints. Immunohistochemical labeling for CD34, α-smooth muscle actin (α-SMA), and vascular endothelial growth factor (VEGF) was performed across proximal, mid-substance, and distal EL regions. Quantitative image analysis using IHC Profiler for ImageJ generated semiquantitative (negative, low-positive, positive) distributions, and inter-ligament comparisons were quantified using t-tests (p  <  0.05). Results: Distinct, region-specific EL signatures were identified. The ACL EL exhibited strong proximal α-SMA expression (0% neg/66.8% low+/33.2%+) and notable distal CD34 positivity (0% neg/83.3% low+/16.7%+), while VEGF expression was confined to the mid-substance (≈55% low+/26%+). In contrast, the MCL EL was largely negative for CD34 and VEGF across all regions, showing a homogeneous but functionally oriented α-SMA profile: proximally negative, sparse mid positivity, and high distal low-positive staining (93.4% low+). Differences in proximal and distal CD34 and α-SMA expression between the ACL and MCL were highly significant (p  <  0.0001–0.001), confirming a mechanistic divergence in EL organization. Conclusions: The ACL EL is regionally heterogeneous, vascularly biased, and enriched in contractile α-SMA+ cells, suggesting localized but poorly coordinated reparative potential. In contrast, the MCL EL is structurally uniform, with distributed α-SMA activity supporting stable wound contraction and tissue continuity, despite limited angiogenic signaling. These findings indicate that the ACL’s failure to heal is not attributable to the absence of progenitor or angiogenic factors, but rather to its fragmented spatial organization and dominant contractile phenotype. Therapeutically, preserving and modulating the EL, particularly its CD34+ and α-SMA+ compartments, could be key to enhancing intrinsic ACL repair and improving outcomes in ligament reconstruction and regeneration. Full article
(This article belongs to the Special Issue Acute Trauma and Trauma Care in Orthopedics: 2nd Edition)
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15 pages, 270 KB  
Review
All-Inside Versus Inside-Out Meniscus Repair: Gaps in the Long-Term Current Evidence
by Cariane Driad, Maika Bazebi, David Mazy and Marie-Lyne Nault
Bioengineering 2026, 13(1), 62; https://doi.org/10.3390/bioengineering13010062 - 6 Jan 2026
Viewed by 161
Abstract
Meniscal repair has become the preferred treatment for many meniscal tears. As a result, multiple arthroscopic techniques have evolved, including the all-inside (AI) and inside-out (IO) approaches, which have been widely studied in the current literature. The present article highlights key limitations in [...] Read more.
Meniscal repair has become the preferred treatment for many meniscal tears. As a result, multiple arthroscopic techniques have evolved, including the all-inside (AI) and inside-out (IO) approaches, which have been widely studied in the current literature. The present article highlights key limitations in studies reporting long-term outcomes (≥5 years), notably the heterogeneity of failure definitions and the lack of subgroup stratification by clinically relevant factors such as age, concomitant anterior cruciate ligament reconstruction (ACLR), and meniscal side (medial vs. lateral). To date, no clear superiority of the AI over the IO approach has been established. Redefining failure through multidimensional approaches that integrate structural, clinical, and patient-reported assessments will be crucial to ensure a consistent and patient-centered evaluation of repair success. Further research with robust subgroup analyses is needed to determine whether one technique confers superior long-term results in specific patient populations. Full article
(This article belongs to the Special Issue Novel Techniques in Meniscus Repair)
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8 pages, 926 KB  
Technical Note
Use of the Vascularized Fascial Flap Based on the 1,2 ICSRA Artery for Scapholunate Ligament Repair: An Anatomic Study
by Enrico Palombo, Simone Otera, Yuri Piccolo, Stefano Gumina, Diego Ribuffo and Alessia Pagnotta
Surgeries 2026, 7(1), 8; https://doi.org/10.3390/surgeries7010008 - 1 Jan 2026
Viewed by 147
Abstract
Scapholunate (SL) ligament injuries, if not properly treated, can compromise wrist biomechanics, leading to instability, scapholunate advanced collapse (SLAC) and progressive osteoarthritis. Depending on the severity of the injury, current repair techniques include either arthroscopic or open surgical approaches; however, the limited vascularization [...] Read more.
Scapholunate (SL) ligament injuries, if not properly treated, can compromise wrist biomechanics, leading to instability, scapholunate advanced collapse (SLAC) and progressive osteoarthritis. Depending on the severity of the injury, current repair techniques include either arthroscopic or open surgical approaches; however, the limited vascularization of the region often represents an obstacle to optimal ligament healing. This study aims to assess the feasibility of using a vascularized fascial flap based on the 1,2 intercompartmental supraretinacular artery (1,2 ICSRA) for biological augmentation of the scapholunate ligament. Five previously injected cadaveric upper limbs were dissected and flap dimensions, including length, width, and pedicle length, were measured using a millimeter-calibrated ruler by two independent operators. All flaps provided sufficient coverage, and the vascular pedicle length allowed tension-free positioning without vascular kinking. These findings demonstrate that a 1,2 ICSRA-based fascial flap is anatomically feasible for scapholunate ligament augmentation. It should be noted that this is a purely cadaveric study, and the technique has not yet been tested in vivo. The results suggest potential surgical applications, providing a vascularized biological option that may enhance ligament healing in future clinical studies. Full article
(This article belongs to the Special Issue Feature Papers in Hand Surgery and Research)
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12 pages, 1763 KB  
Article
Poor Prognostic Factors in Surgically Treated Habitual Patellar Dislocation in Children and Adolescents
by Alexandru Ulici, Mihai-Codrut Dragomirescu, Sorina-Mariana Mocanu and Alexandru Herdea
Children 2026, 13(1), 68; https://doi.org/10.3390/children13010068 - 31 Dec 2025
Viewed by 154
Abstract
Background/Objectives: Habitual patellar dislocation is a rare but debilitating form of patellofemoral instability in children and adolescents, frequently associated with underlying anatomical abnormalities and ligamentous laxity. Despite multiple surgical techniques, recurrence and suboptimal functional recovery remain concerns. This study aimed to identify the [...] Read more.
Background/Objectives: Habitual patellar dislocation is a rare but debilitating form of patellofemoral instability in children and adolescents, frequently associated with underlying anatomical abnormalities and ligamentous laxity. Despite multiple surgical techniques, recurrence and suboptimal functional recovery remain concerns. This study aimed to identify the demographic, clinical, and imaging factors associated with postoperative recurrence and poorer functional outcomes in pediatric patients surgically treated for habitual patellar dislocation. Methods: A retrospective cohort study was conducted on pediatric patients treated between 2016 and 2024 for habitual patellar dislocation. Inclusion criteria required age ≤ 18 years, a minimum 12-month follow-up, and complete imaging documentation. Clinical evaluation included the Beighton hyperlaxity score, lower-limb alignment, and Lysholm Knee Score. Imaging parameters assessed patellar height (Caton–Deschamps Index), trochlear dysplasia, patellar tilt, patellar subluxation, genu valgum, and tibial tubercle–trochlear groove (TT–TG) distance. Surgical treatment consisted of individualized combinations of soft-tissue realignment, quadriceps lengthening, Roux–Goldthwait procedures, and MPFL reconstruction. Statistical analyses evaluated predictors of recurrence and postoperative Lysholm score. Results: Thirty-four patients (45 knees; mean age 12 years; 73.5% female) were included. Preoperative Lysholm scores improved from a mean of 73 to 94 postoperatively (p < 0.0001). Recurrence occurred in 32.35% of patients and was significantly associated with generalized hyperlaxity (p = 0.0041), trochlear dysplasia (p = 0.045), and lateral patellar subluxation (p = 0.039). Suboptimal postoperative Lysholm scores (<85) were observed in 11.76% of patients, all with recurrence, and were significantly associated with genu valgum (p = 0.0011) and patella alta (p = 0.036). No significant associations were found for rotational deformities or femoral condyle hypoplasia. Conclusions: Habitual patellar dislocation in children is multifactorial, and the likelihood of recurrence increases with cumulative risk factors such as hyperlaxity, trochlear dysplasia, lateral subluxation, patella alta, and genu valgum. Comprehensive preoperative assessment is essential to guide combined, individualized surgical strategies that optimize stability and functional recovery. No single technique is universally curative; rather, tailored multimodal approaches yield the most favorable outcomes. Full article
(This article belongs to the Section Pediatric Orthopedics & Sports Medicine)
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15 pages, 815 KB  
Article
Differing Definitions of Outpatient Surgery May Influence Study Outcomes Related to ACL Reconstruction
by Ryan Hoang, Junho Song, Arthur W. Cowman, Timothy Hoang, Alexander Yu, Justin Tiao, Haiyue Jin and Robert L. Parisien
J. Clin. Med. 2026, 15(1), 227; https://doi.org/10.3390/jcm15010227 - 27 Dec 2025
Viewed by 200
Abstract
Background: Anterior cruciate ligament reconstruction (ACLR), one of the most frequently performed orthopedic procedures, has experienced rising demand and escalating costs, driving efforts to reduce expenses through shorter hospital stays and an increased shift toward outpatient settings. This study aims to evaluate how [...] Read more.
Background: Anterior cruciate ligament reconstruction (ACLR), one of the most frequently performed orthopedic procedures, has experienced rising demand and escalating costs, driving efforts to reduce expenses through shorter hospital stays and an increased shift toward outpatient settings. This study aims to evaluate how differing definitions of “outpatient” surgery influence the interpretation of outcomes following ACLR. Methods: ACS-NSQIP was queried for patients undergoing primary ACL reconstruction between 2014 and 2023. Patients ≥ 18 years with CPT code 29888 were included. Patients with missing hospital length of stay (LOS) data or a LOS > 2 days (≥99th percentile) were excluded. Two definitions of “outpatient” surgery were evaluated: hospital-defined outpatient (HDO) and same-day discharge (SDD, LOS = 0). Propensity score matching of baseline demographics and comorbidities was used to compare HDO and SDD cohorts to their respective inpatient counterparts. Primary outcomes analyzed included 30-day readmission, reoperation, and postoperative complications. Univariate and multivariate analyses were performed to compare risks of complications for HDO and SDD cohorts compared to their inpatient counterparts. Results: A total of 37,546 patients were included in this study, with 35,334 HDO (94.1%) and 34,801 (92.7%) SDD cases. 1021 (2.9%) of the 35,334 HDO patients had an inpatient hospital stay of at least 1 night. In propensity-matched cohorts, hospital-defined inpatient ACLR was associated with significantly greater risk of 30-day reoperation (odds ratio [OR] 3.167, 95% CI 1.267–7.915, p = 0.009) and superficial surgical site infection (SSI) (OR 5.0, 95% CI 1.712–14.604 p = 0.001), while HDO ACLR was associated with increased risk of deep vein thrombosis (DVT) (OR 0.333, 95% CI 0.121–0.916, p = 0.025). Compared to the propensity-matched SDD cohort, inpatient ACLR was significantly associated with greater rates of 30-day readmission (OR 1.988, 95% CI 1.088–3.630, p < 0.001), reoperation (OR 3.222, 95% CI 1.528–6.794, p = 0.001), and superficial SSI (OR 3.286, 95% CI 1.412–7.644, p = 0.003). Conclusions: This study found differences in readmission and deep vein thrombosis between HDO and SDD cohorts when compared to inpatient ACLR. A standardized definition of outpatient surgery should be created to clearly distinguish same-day discharge from other outpatient categories, considering discharge timing and patient monitoring practices. Full article
(This article belongs to the Section Orthopedics)
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11 pages, 992 KB  
Article
Influence of Intra-Articular Tunnel Aperture Morphology on Clinical Outcomes and Graft Rerupture After ACL Reconstruction
by Yusuf Iyetin, Emre Koraman, Mehmet Akan, Ismail Turkmen and Muhlik Akyurek
J. Clin. Med. 2026, 15(1), 172; https://doi.org/10.3390/jcm15010172 - 25 Dec 2025
Viewed by 206
Abstract
Background/Objectives: Variations in drill orientation during femoral and tibial tunnel creation can alter intra-articular tunnel aperture morphology in anterior cruciate ligament (ACL) reconstruction. Enlarged or irregular apertures may affect graft–tunnel conformity and graft mechanics. This study aimed to assess the relationship between intra-articular [...] Read more.
Background/Objectives: Variations in drill orientation during femoral and tibial tunnel creation can alter intra-articular tunnel aperture morphology in anterior cruciate ligament (ACL) reconstruction. Enlarged or irregular apertures may affect graft–tunnel conformity and graft mechanics. This study aimed to assess the relationship between intra-articular femoral and tibial tunnel aperture areas, postoperative clinical outcomes, and graft rerupture. This study specifically focuses on MRI-based measurement of intra-articular tunnel aperture area, a morphological parameter that has not been routinely evaluated in previous ACL reconstruction studies and differs conceptually from tunnel diameter or drilling angles. Methods: This retrospective case–control study included patients who underwent primary ACL reconstruction with an 8 mm hamstring autograft using the anteromedial portal technique. All patients completed a minimum 2-year follow-up and postoperative MRI. Femoral and tibial intra-articular aperture areas were measured on MRI Clinical outcomes (Lysholm scores and KOOSs) in patients with intact grafts. Patients were categorized into intact-graft and rerupture groups. Correlation analyses were used to evaluate associations between aperture areas and clinical outcomes. Logistic regression identified predictors of rerupture. Results: A total of 152 patients met the inclusion criteria, including 13 with graft rerupture. In the intact-graft group, mean femoral and tibial aperture areas were 127.34 ± 8.92 mm2 and 138.33 ± 7.08 mm2, respectively. Both aperture areas demonstrated significant negative correlations with Lysholm scores and KOOSs. Patients with rerupture had significantly larger femoral (145.26 ± 4.22 mm2) and tibial (158.02 ± 2.88 mm2) aperture areas (p < 0.001 for both). Logistic regression identified tibial aperture area as a significant predictor of rerupture. Conclusions: Larger intra-articular tunnel aperture areas were associated with inferior functional outcomes, and increased tibial aperture area correlated significantly with graft rerupture. Aperture morphology may represent an important factor influencing graft integrity and postoperative recovery after ACL reconstruction. Full article
(This article belongs to the Section Orthopedics)
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14 pages, 420 KB  
Article
Effects of Visual Perturbation on Single-Leg Drop Jump Biomechanics in Patients Post-Anterior Cruciate Ligament Reconstruction
by Xavier Laurent, Damien Dodelin, Nicolas Graveleau and Nicolas Bouguennec
J. Clin. Med. 2026, 15(1), 118; https://doi.org/10.3390/jcm15010118 - 24 Dec 2025
Viewed by 301
Abstract
Background: Patients after anterior cruciate ligament reconstruction (ACLR) often exhibit persistent biomechanical deficits, particularly during high-demand tasks like the single-leg drop jump (SLDJ). At approximately six months post-ACLR, patients frequently rely on visual input to compensate for persistent sensorimotor deficits during dynamic [...] Read more.
Background: Patients after anterior cruciate ligament reconstruction (ACLR) often exhibit persistent biomechanical deficits, particularly during high-demand tasks like the single-leg drop jump (SLDJ). At approximately six months post-ACLR, patients frequently rely on visual input to compensate for persistent sensorimotor deficits during dynamic tasks, which may lead to altered movement patterns. While visual perturbations have been studied in bilateral jump tasks, their impact on SLDJ biomechanics in ACLR patients remains unexplored. Methods: Patients who were still engaged in rehabilitation and not yet cleared for unrestricted return to sport performed SLDJ under three visual conditions: normal vision, low visual perturbation, and high visual perturbation using stroboscopic glasses. Kinematic and kinetic variables were measured using a 3-dimensional motion analysis system and force platform. Comparisons were made between the ACLR and non-operated limbs, as well as across visual conditions. Results: 24 patients (17 males, 7 females; mean age 25.6 ± 6.3 years, mean height 174 ± 9.0 cm, mean weight 74.7 ± 17.2 kg) were included in the analysis. Knee adduction excursion during landing was significantly affected by visual perturbation (F(2, 46) = 6.55, p = 0.004, η2 = 0.019). Post hoc analysis showed that high visual perturbation significantly decreased knee adduction excursion compared to normal vision on the ACLR limb (mean difference 1.499°, SE = 0.388, pBonf = 0.003, Cohen’s d = 0.542). A significant difference was also found between low and high visual perturbation on the ACLR limb (mean difference 1.543°, SE = 0.388, pBonf = 0.002, Cohen’s d = 0.558). No significant changes were observed in the non-operated limb across visual conditions. Conclusions: High visual perturbation significantly altered knee adduction excursion on the ACLR limb, resulting in a shift toward greater knee abduction during landing. No changes were observed in the non-operated limb. These findings support the use of visual perturbation in functional assessment protocols after ACLR to better identify persistent biomechanical deficits that may contribute to reinjury risk. Full article
(This article belongs to the Special Issue Anterior Cruciate Ligament (ACL): Innovations in Clinical Management)
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22 pages, 1333 KB  
Systematic Review
Gait Biomechanical Differences in the Anterior Cruciate Ligament Reconstructed and Contralateral Limb: A Systematic Review with Meta-Analysis
by Heidar Sajedi, Elif Aydın, Mehmet Şirin Güler, Selahattin Akpınar, Ali Esmaeili, AmirAli Jafarnezhadgero and Kate E. Webster
Healthcare 2025, 13(24), 3304; https://doi.org/10.3390/healthcare13243304 - 16 Dec 2025
Viewed by 362
Abstract
Background: In this systematic review with meta-analysis, we aimed to compare the kinematic and kinetic variables of the involved limb with the contralateral limb in individuals who had undergone an anterior cruciate ligament reconstruction (ACLR) recorded during walking from short-term (<6 months) to [...] Read more.
Background: In this systematic review with meta-analysis, we aimed to compare the kinematic and kinetic variables of the involved limb with the contralateral limb in individuals who had undergone an anterior cruciate ligament reconstruction (ACLR) recorded during walking from short-term (<6 months) to mid-term (6–<12 months) and long-term (≥12 months) periods after surgery. Methods: Five electronic databases (Scopus, PubMed, EMBASE, PEDro, CENTRAL) were systematically searched for articles potentially eligible for inclusion from inception until November 2025. Biomechanical gait patterns were assessed short-term (<6 months), mid-term (6–<12 months), and long-term (≥12 months) post-surgery. Gait biomechanics were extracted from the included articles. Comparisons were made between the affected limb and the contralateral limb. Standardized mean differences (SMDs) with 95% confidence intervals (CI) were computed using a random-effects model. Results: The systematic search revealed 3522 hits, and according to a priori defined in-/exclusion criteria, 32 studies with male and female individuals aged 18–55 years involving 1026 participants were included. Meta-analysis indicated that the peak knee flexion angle was significantly lower in the ACLR compared to the contralateral limb (19 studies: small SMDs = −0.39, 95% CI −0.58 to −0.19, p < 0.0001, I2 = 66%). More specifically, the peak knee flexion angle was 2.63° (95% CI −3.81 to −1.44) lower in the ACLR compared to the contralateral limb. The analysis of time post-surgery revealed significant differences in the short-term (four studies: large SMDs = −1.14, 95% CI −1.61 to −0.67, p < 0.00001, I2 = 56%) and mid-term (five studies: small SMDs = −0.52, 95% CI −0.74 to −0.29, p < 0.0001, I2 = 0%) periods after surgery but not for the long-term follow-up (10 studies: small SMDs = −0.10, 95% CI −0.27 to 0.07, p = 0.26, I2 = 32%). Meta-analysis indicated that the peak knee flexion moment was significantly lower in the ACLR compared to the contralateral limb (11 studies: small SMDs = −0.37, 95% CI −0.59 to −0.14, p = 0.0001, I2 = 46%). A lower peak knee flexion moment was observed in the ACLR limb for both less than 12 months (three studies: moderate SMDs = −0.76, 95% CI −1.44 to −0.07, p = 0.03, I2 = 66%) and over 12 months (eight studies: small SMDs = −0.25, 95% CI −0.43 to −0.07, p = 0.01, I2 = 46%) after surgery time points compared to the contralateral limb. Conclusion: These findings suggest a time-dependent compensatory mechanism, where protective adaptations (e.g., reduced flexion/extension moments) may initially offload the reconstructed limb, with some asymmetries resolving over time. Clinically, these results underscore the need for rehabilitation strategies tailored to address phase-specific deficits, promoting symmetrical loading and functional recovery. Full article
(This article belongs to the Special Issue From Prevention to Recovery in Sports Injury Management)
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15 pages, 1052 KB  
Systematic Review
Effects of Transcranial Neuromodulation on Rehabilitation Outcomes After Anterior Cruciate Ligament Injury: A Systematic Review of Randomized Controlled Trials
by Juan Vicente-Mampel, Mariola Belda-Antolí, Eloy Jaenada-Carrilero, Andrés Pascual-Leone, Luís Baraja-Vegas, Nicolás Pascual-Leone, Javier Ferrer-Torregrosa, Francisco J. Falaguera-Vera, Álvaro Pascual-Leone and José María Tormos-Muñoz
Biomedicines 2025, 13(12), 3068; https://doi.org/10.3390/biomedicines13123068 - 12 Dec 2025
Viewed by 450
Abstract
Background/Objectives: Anterior cruciate ligament (ACL) injuries frequently lead to long-term quadriceps impairments despite surgical repair. There is growing evidence that these deficits are caused in part by alterations in the central nervous system. Thus, transcranial neuromodulation (TNM) could be valuable in ACL [...] Read more.
Background/Objectives: Anterior cruciate ligament (ACL) injuries frequently lead to long-term quadriceps impairments despite surgical repair. There is growing evidence that these deficits are caused in part by alterations in the central nervous system. Thus, transcranial neuromodulation (TNM) could be valuable in ACL rehabilitation. To systematically review randomized controlled trials (RCTs) assessing the effects of TNM on neurophysiological, functional, and safety outcomes in patients with ACL injury or reconstruction. Methods: We conducted searches on PubMed, Scopus, Web of Science, and Cochrane. We considered all original studies evaluating TNM, including transcranial current stimulation (tCS) and transcranial magnetic stimulation (TMS), in patients with ACL reconstruction or injury. Measures of corticospinal excitability, safety, balance, and muscle strength were assessed. We employed the Cochrane RoB 2 method to assess the risk of bias. Results: Seven studies comprising 129 participants (64 TNM, 65 controls) were included. Most studies applied transcranial direct current stimulation (tDCS) over the primary motor cortex contralateral to the ACL injury in conjunction with physical rehabilitation. Single-session protocols demonstrated minimal effects, whereas repeated sessions resulted in improvements in corticospinal excitability, quadriceps strength, and balance. No serious adverse events were reported; minor effects included transient headache or scalp tingling. The risk of bias was assessed as low to moderate across the studies. Conclusions: TNM appears to be safe and may enhance functional recovery in individuals with ACL injuries when administered in multiple sessions alongside standard rehabilitation. Further high-quality trials are necessary to determine optimal protocols and long-term outcomes. Full article
(This article belongs to the Section Neurobiology and Clinical Neuroscience)
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15 pages, 1600 KB  
Article
Sensory Deficit Following Anterior Cruciate Ligament Reconstruction with Bone–Patellar Tendon–Bone Autograft: Platelet-Rich Fibrin (PRF) Could Provide a Solution
by Darko Milovanovic, Marko Kadija, Dusica Gavrilović, Svetlana Sreckovic, Miljan Bilanovic, Aleksandar Matić and Petar Vukman
Medicina 2025, 61(12), 2202; https://doi.org/10.3390/medicina61122202 - 12 Dec 2025
Viewed by 351
Abstract
Background and Objectives: Despite the high rate of donor site morbidity, a bone–patellar tendon–bone (BPTB) graft remains the gold standard when choosing a graft for anterior cruciate ligament (ACL) reconstruction. Damage to the infrapatellar branch of the saphenous nerve (IPBSN) during graft [...] Read more.
Background and Objectives: Despite the high rate of donor site morbidity, a bone–patellar tendon–bone (BPTB) graft remains the gold standard when choosing a graft for anterior cruciate ligament (ACL) reconstruction. Damage to the infrapatellar branch of the saphenous nerve (IPBSN) during graft harvesting results in sensory deficits. Despite its high occurrence in the postoperative period, many patients go untreated, leading to a lower quality of life and potential professional impairment. The aim of this study was to assess the effectiveness of PRF therapy in alleviating sensory deficits and enhancing sensory nerve function in patients who have undergone BTB ACL reconstruction. Materials and Methods: This study was registered at ClinicalTrials.gov (Name of registry: ClinicalTrials.gov; Trial registration number: NCT07257666; Date of registration: 2 December 2025; Study start date: 7 January 2022). Over a one-year period, the pilot study enrolled 53 patients, treated them with BPTB ACL reconstruction, and divided them into two groups. The testing group’s donor site and subcutaneous tissue were treated with Vivostat® PRF, whereas the standard group’s donor site and subcutaneous tissue remained untreated. The primary outcome measured was a reduction in the subjective numbness, which was tested during follow-up checks. Secondary outcomes included the evaluation of subjective knee scores for functional recovery, reported by the patients on control exams. Results: The use of Vivostat® PRF resulted in a statistically significant reduction in sensory deficit among the groups at eight months (p < 0.05) and twelve months (p < 0.01) following surgery, favoring the testing group. The most substantial decrease in symptomatic patients was observed between four and eight months post-surgery, with no statistically significant difference found between the eight- and twelve-month follow-ups (p > 0.05). Evaluations of subjective knee function and activity scores showed no statistically significant differences between the groups. Conclusions: Using Vivostat® PRF helps reduce sensory impairment in the area and minimizes donor site morbidity after BPTB ACL reconstruction. Full article
(This article belongs to the Special Issue The Role of Arthroscopy in Modern Orthopedics)
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21 pages, 1570 KB  
Case Report
Applying Differential Learning During Rehabilitation After Anterior Cruciate Ligament Injury: A Basketball Single-Case Study
by Jorge Arede, Rui Zhou, Harjiv Singh and Wolfgang I. Schöllohrn
Healthcare 2025, 13(24), 3247; https://doi.org/10.3390/healthcare13243247 - 11 Dec 2025
Viewed by 868
Abstract
Background/Objectives: Differential learning (DL) amplifies natural fluctuations in movement execution and, in its more extreme forms, facilitates repetition-free training with minimal external feedback. While increasingly recognized in the field of skill acquisition, its application in anterior cruciate ligament (ACL) rehabilitation remains underexplored. [...] Read more.
Background/Objectives: Differential learning (DL) amplifies natural fluctuations in movement execution and, in its more extreme forms, facilitates repetition-free training with minimal external feedback. While increasingly recognized in the field of skill acquisition, its application in anterior cruciate ligament (ACL) rehabilitation remains underexplored. Methods: This study examined the application of DL in the rehabilitation of an 18-year-old trained basketball player following left-ACL reconstruction. The athlete completed a 42-week rehabilitation program in which DL principles were incorporated throughout the pre-operative, early, mid-, and late phases, culminating in return to sport. Training included differential mobility work, motor control, plyometric exercises, and sport-specific drills. Functional recovery was evaluated using single-leg hop tests, change-of-direction tasks, and sprint performance, while self-reported knee function was monitored via the International Knee Documentation Committee (IKDC) questionnaire. Results: Results indicated substantial improvements in both functional performance and psychological readiness. The IKDC score increased from 13.8% at baseline to 95.4% postoperatively, reaching the normal functional range. An ACL-RSI score of 85.2%, and inter-limb asymmetries were reduced to below 10%. Strength, agility, and sprint performance exceeded pre-injury levels. Conclusions: DL again shows potential as an effective approach to facilitating recovery and return to sport after ACL reconstruction, but larger controlled studies are needed for validation. Full article
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10 pages, 274 KB  
Article
Medial Patellofemoral Ligament Reconstruction: Patient-Reported Outcome Measures Comparing Autograft and Allograft Tendons with or Without Tibial Tubercle Osteotomy
by Eli Beach, Daniel George, Claire Bolton and Shahram Shahrokhi
J. Clin. Med. 2025, 14(24), 8756; https://doi.org/10.3390/jcm14248756 - 10 Dec 2025
Viewed by 355
Abstract
Objectives: To compare patient-reported outcome measures (PROMS) as the primary outcome following medial patellofemoral ligament reconstruction (MPFLR) using autograft versus allograft tendon. Secondary objectives were to assess re-dislocation rates and evaluate the effect of concomitant tibial tubercle osteotomy (TTO) on PROMs. Methods: Eighty-eight [...] Read more.
Objectives: To compare patient-reported outcome measures (PROMS) as the primary outcome following medial patellofemoral ligament reconstruction (MPFLR) using autograft versus allograft tendon. Secondary objectives were to assess re-dislocation rates and evaluate the effect of concomitant tibial tubercle osteotomy (TTO) on PROMs. Methods: Eighty-eight patients from two fellowship-trained orthopaedic surgeons operating at a single institution between 2018 and 2023 were identified. Eligible patients, including those who had undergone an MPFLR with either autograft or allograft +/− TTO, were contacted to complete three validated surveys to quantify PROMS: the Kujala Anterior Knee Pain Score (Kujala), the Marx Activity Score (Marx), and the Norwich Patellar Instability Score (NPI). Exclusion criteria included musculoskeletal or collage disorders and incomplete PROMs. Re-dislocation rates and PROMS were compared between autograft and allograft groups. Independent samples t-tests were used, with p < 0.05 considered statistically significant. Results: A total of fifty-nine patients (46% male, average age 28.5 years old) representing 63 knees returned PROMs. All Kujala scores were similar between groups. Subgroup analysis revealed that patients who received an isolated MPFLR compared to those who received an MPFLR with TTO had lower NPI scores: 22.89% versus 30.21% (p < 0.001), respectively. Those who underwent isolated MPLFR with autograft compared to allograft had lower Marx scores: 7.40 versus 7.70 (p = 0.031), respectively. One patient who underwent an allograft experienced a recurrence of their patellar instability. Conclusions: There was a low recurrent patella dislocation rate following MPFLR and similar anterior knee pain scores in our study when comparing autograft with allograft. Full article
(This article belongs to the Section Orthopedics)
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